Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0127 | 0.0072 | 0.0163 |
Echinococcus multilocularis | integrin beta 2 | 0.0227 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0207 | 0.0388 | 0.0874 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.028 | 0.0678 | 0.2341 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0265 | 0.0618 | 0.0618 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0912 | 0.3181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0381 | 0.086 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.006 | 0.0225 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0131 | 0.0087 | 0.0087 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0912 | 0.3181 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0294 | 0.0731 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0265 | 0.0618 | 0.1393 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0487 | 0.1496 | 0.3373 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.2633 | 1 | 1 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0259 | 0.0592 | 0.1861 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0787 | 0.2685 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0118 | 0.0265 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0205 | 0.0381 | 0.0381 |
Mycobacterium ulcerans | zinc metalloprotease | 0.028 | 0.0678 | 0.2341 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0912 | 0.3181 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0294 | 0.0731 | 0.2297 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0265 | 0.0618 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0388 | 0.0874 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0912 | 0.3181 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0787 | 0.2685 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0141 | 0.0128 | 0.0401 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0912 | 0.3181 | 0.3181 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0124 | 0.006 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.028 | 0.0678 | 0.0678 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0259 | 0.0592 | 0.1861 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0678 | 0.1527 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0487 | 0.1496 | 0.1496 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0487 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0207 | 0.0388 | 0.0874 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.028 | 0.0678 | 0.1527 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0912 | 0.3181 | 0.7171 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0912 | 0.3181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0388 | 0.0874 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.028 | 0.0678 | 0.213 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0141 | 0.0128 | 0.0401 |
Onchocerca volvulus | 0.0205 | 0.0381 | 0.4301 | |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0259 | 0.0592 | 0.1335 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0205 | 0.0381 | 0.0381 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0912 | 0.3181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0381 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0265 | 0.0618 | 0.2112 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0283 | 0.0688 | 0.2382 |
Schistosoma mansoni | integrin beta subunit | 0.0181 | 0.0284 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0678 | 0.1527 |
Brugia malayi | hypothetical protein | 0.0205 | 0.0381 | 0.086 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0131 | 0.0087 | 0.0087 |
Echinococcus granulosus | caspase 2 | 0.0294 | 0.0731 | 0.0731 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0265 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0487 | 0.1496 | 0.4704 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0912 | 0.3181 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0912 | 0.3181 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0294 | 0.0731 | 0.0731 |
Brugia malayi | Peptidase family M13 containing protein | 0.028 | 0.0678 | 0.1527 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1229 | 0.4436 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.028 | 0.0678 | 0.2341 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.0592 | 0.1335 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.028 | 0.0678 | 0.0678 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0912 | 0.3181 | 0.3181 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0141 | 0.0128 | 0.0401 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0307 | 0.0784 | 0.1768 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.0731 | 0.1647 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.006 | 0.0225 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.1229 | 0.4436 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0131 | 0.0087 | 0.0087 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.006 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0618 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0388 | 0.0874 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.0912 | 0.3181 | 0.7171 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0787 | 0.2685 | 1 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0912 | 0.3181 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0265 | 0.0618 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0678 | 0.1527 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0787 | 0.2685 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0131 | 0.0088 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 0.1496 | 0.3373 |
Loa Loa (eye worm) | integrin beta-2 | 0.0307 | 0.0784 | 0.1768 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0787 | 0.2685 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0227 | 0.0469 | 0.0469 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0141 | 0.0128 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0407 | 0.0918 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0141 | 0.0128 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0388 | 0.0874 |
Brugia malayi | Cell death protein 3 precursor | 0.0294 | 0.0731 | 0.1647 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0265 | 0.0618 | 0.0353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Effective dose of the compound was measured in rats using maximal electroshock seizure test(ip); showed no protection up to 100 mg/kg (i.p. dose) | ChEMBL. | No reference |
ED50 (functional) | 0 mg kg-1 | Effective dose of the compound was measured in rats using maximal electroshock seizure test(ip); showed no protection up to 120 mg/kg (i.p. dose) | ChEMBL. | No reference |
Protection (functional) | = 0 % | % protection of the compound was measured in rats using maximal electroshock seizure test | ChEMBL. | No reference |
Protection (functional) | = 0 % | % protection of the compound was measured in rats using subcutaneous pentylenetetrazole seizure test | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.