Detailed information for compound 261668

Basic information

Technical information
  • TDR Targets ID: 261668
  • Name: N-[4-(3,4-dichlorophenyl)butyl]-2-[[2-(4-hydr oxyphenyl)ethylamino]methyl]benzamide
  • MW: 471.419 | Formula: C26H28Cl2N2O2
  • H donors: 3 H acceptors: 2 LogP: 6.09 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)CCNCc1ccccc1C(=O)NCCCCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C26H28Cl2N2O2/c27-24-13-10-20(17-25(24)28)5-3-4-15-30-26(32)23-7-2-1-6-21(23)18-29-16-14-19-8-11-22(31)12-9-19/h1-2,6-13,17,29,31H,3-5,14-16,18H2,(H,30,32)
  • InChiKey: DLPQNLKXLASOCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium-dependent proline transporter, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Get druggable targets OG5_128673 All targets in OG5_128673
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.193 0.5
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.6302 0.6316
Schistosoma mansoni tensin-related 0.006 0.3135 0.3142
Echinococcus granulosus tyrosine protein kinase ABL1 0.0077 0.4665 0.4665
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0097 0.6411 0.6425
Brugia malayi Src substrate cortactin 0.0059 0.3 0.3006
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.4288 0.4297
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0059 0.3 0.3
Brugia malayi Sex muscle abnormal protein 5 0.0119 0.8449 0.8467
Schistosoma mansoni tyrosine kinase 0.0077 0.4665 0.4675
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Echinococcus multilocularis nostrin 0.0059 0.3 0.3006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0047 0.193 0.1934
Schistosoma mansoni tyrosine kinase 0.0077 0.4665 0.4675
Schistosoma mansoni tensin 0.006 0.3135 0.3142
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0028 0.0176 0.0176
Echinococcus granulosus N chimaerin 0.006 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.193 0.5
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0059 0.3 0.3006
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Brugia malayi Variant SH3 domain containing protein 0.0119 0.8449 0.8467
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.6302 0.6316
Echinococcus granulosus hypothetical protein 0.006 0.3135 0.3135
Schistosoma mansoni tensin 0.006 0.3135 0.3142
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0047 0.193 0.193
Echinococcus multilocularis SH2 motif 0.006 0.3135 0.3142
Echinococcus granulosus endophilin A3 0.0059 0.3 0.3
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.6411 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.3135 0.3135
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0136 0.9979 1
Echinococcus granulosus NCK adaptor protein 0.0119 0.8449 0.8449
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.3135 0.3142
Onchocerca volvulus 0.0059 0.3021 0.0129
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0039 0.1159 0.1162
Loa Loa (eye worm) hypothetical protein 0.0069 0.3885 0.3894
Echinococcus multilocularis Spectrin alpha actinin 0.0059 0.3 0.3006
Loa Loa (eye worm) hypothetical protein 0.0096 0.6302 0.6316
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.9979 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.9979 0.9979
Onchocerca volvulus 0.006 0.3135 0.0812
Loa Loa (eye worm) hypothetical protein 0.0077 0.4665 0.4675
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0072 0.4166 0.6399
Entamoeba histolytica SH2 domain containing protein 0.006 0.3135 0.4745
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Echinococcus multilocularis tyrosine kinase 0.0077 0.4665 0.4675
Echinococcus granulosus fch and double sh3 domains protein 2 0.0059 0.3 0.3
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.006 0.3135 0.0812
Schistosoma mansoni tyrosine-protein kinase zap-70 0.006 0.3135 0.3142
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.3 0.4529
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Loa Loa (eye worm) guanylate kinase 0.0059 0.3 0.3006
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.6302 0.6302
Echinococcus multilocularis intersectin 2 0.0059 0.3 0.3006
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.3 0.3608
Brugia malayi serine/threonine-protein kinase plk-2 0.0073 0.4288 0.4297
Echinococcus multilocularis SH2 motif 0.006 0.3135 0.3142
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0059 0.3 0.3006
Echinococcus granulosus src region 0.0059 0.3 0.3
Echinococcus granulosus suppressor of cytokine signaling 7 0.006 0.3135 0.3135
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.9979 1
Echinococcus multilocularis tensin 0.006 0.3135 0.3142
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.006 0.3135 0.3142
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.006 0.3135 0.3135
Schistosoma mansoni Dab2-interacting protein-like 0.0059 0.3 0.3006
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Schistosoma mansoni dynamin-associated protein 0.0059 0.3 0.3006
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0039 0.1159 0.1162
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0059 0.3 0.3
Echinococcus multilocularis tyrosine protein kinase Blk 0.0077 0.4665 0.4675
Echinococcus multilocularis tensin 0.006 0.3135 0.3142
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Brugia malayi latrophilin 2 splice variant baaae 0.0055 0.2686 0.2692
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0039 0.1159 0.0159
Echinococcus granulosus SH2 domain containing adapter protein F 0.006 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Echinococcus multilocularis SHC transforming protein 3 0.006 0.3135 0.3142
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0059 0.3 0.3
Loa Loa (eye worm) protein-tyrosine kinase 0.0059 0.3 0.3006
Brugia malayi Variant SH3 domain containing protein 0.0119 0.8449 0.8467
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0059 0.3 0.3006
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.3135 0.3142
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0136 0.9979 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Entamoeba histolytica protein kinase, putative 0.0059 0.3 0.4529
Echinococcus multilocularis SH2 motif 0.006 0.3135 0.3142
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Echinococcus multilocularis NCK adaptor protein 0.0119 0.8449 0.8467
Brugia malayi cytokine inducible SH2-containing protein 5 0.006 0.3135 0.3142
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0044 0.164 0.1061
Onchocerca volvulus 0.0077 0.4665 1
Schistosoma mansoni shc transforming protein 0.006 0.3135 0.3142
Loa Loa (eye worm) SRC-1 0.0136 0.9979 1
Leishmania major hypothetical protein, conserved 0.0059 0.3 0.6866
Echinococcus granulosus growth factor receptor bound protein 2 0.0119 0.8449 0.8449
Trypanosoma brucei conserved protein 0.0059 0.3 0.5882
Entamoeba histolytica BAR/SH3 domain containing protein 0.0059 0.3 0.4529
Schistosoma mansoni sorting nexin 0.0059 0.3 0.3006
Echinococcus multilocularis tyrosine protein kinase shark 0.0077 0.4665 0.4675
Brugia malayi protein-tyrosine kinase 0.0059 0.3 0.3006
Schistosoma mansoni tyrosine kinase 0.0136 0.9979 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0077 0.4665 0.4675
Echinococcus granulosus nostrin 0.0059 0.3 0.3
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0136 0.9979 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0047 0.193 0.4265
Echinococcus granulosus tyrosine protein kinase Srms 0.0077 0.4665 0.4665
Echinococcus granulosus suppressor of cytokine signaling 6 0.006 0.3135 0.3135
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0077 0.4665 0.4665
Brugia malayi Fes/CIP4 homology domain containing protein 0.0059 0.3 0.3006
Schistosoma mansoni suppressor of cytokine signaling 0.006 0.3135 0.3142
Brugia malayi hypothetical protein 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.0096 0.6302 0.6316
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0954 0.1248
Echinococcus multilocularis SH2 domain containing adapter protein F 0.006 0.3135 0.3142
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Loa Loa (eye worm) hypothetical protein 0.0081 0.5 0.5011
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.193 0.1934
Echinococcus granulosus SH2 domain containing protein 7 0.006 0.3135 0.3135
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0039 0.1159 0.1162
Schistosoma mansoni dreadlocks/dock 0.0059 0.3 0.3006
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Echinococcus multilocularis transfer RNA-Ala 0.0059 0.3 0.3006
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Schistosoma mansoni SH2A 0.006 0.3135 0.3142
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0069 0.3885 0.3885
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0081 0.5 0.5011
Echinococcus multilocularis tyrosine protein kinase Abl 0.0136 0.9979 1
Schistosoma mansoni sorbin 0.0059 0.3 0.3006
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 0.3156 0.478
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Onchocerca volvulus 0.006 0.3135 0.0812
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.006 0.3135 0.3142
Schistosoma mansoni hypothetical protein 0.006 0.3135 0.3142
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0097 0.6411 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0028 0.0176 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.3135 0.3142
Schistosoma mansoni hypothetical protein 0.0055 0.2686 0.2692
Loa Loa (eye worm) thyroid receptor interactor 0.0059 0.3 0.3006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.006 0.3135 0.3142
Brugia malayi Protein kinase domain containing protein 0.0077 0.4665 0.4675
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.3 0.3608
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.006 0.3135 0.0812
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.3 0.4529
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0077 0.4665 0.4665
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0077 0.4665 0.4675
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.4288 0.6022
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.006 0.3135 0.3142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.164 0.2348
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0119 0.8449 0.8467
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0097 0.6411 1
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Echinococcus multilocularis N chimaerin 0.006 0.3135 0.3142
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.164 0.1537
Echinococcus granulosus SH2 motif 0.006 0.3135 0.3135
Echinococcus granulosus SH2 motif 0.006 0.3135 0.3135
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0047 0.193 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0136 0.9979 0.9979
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0039 0.1159 0.1159
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.4288 0.6022
Schistosoma mansoni apoptosis stimulating of P53 0.0059 0.3 0.3006
Schistosoma mansoni growth factor receptor-bound protein 0.0119 0.8449 0.8467
Schistosoma mansoni GTPase activating protein 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Brugia malayi Protein-tyrosine phosphatase containing protein 0.006 0.3135 0.3142
Brugia malayi Calcitonin receptor-like protein seb-1 0.0081 0.5 0.5011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.006 0.3135 0.3142
Onchocerca volvulus 0.006 0.3135 0.0812
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.164 0.2348
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0119 0.8449 0.8467
Echinococcus granulosus signal transduction protein lnk realted 0.006 0.3135 0.3135
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0059 0.3 0.3
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.3135 0.3142
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0077 0.4665 0.7199
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Onchocerca volvulus 0.0077 0.4665 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0077 0.4665 0.4675
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.009 0.5845 0.9092
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.6324 0.6338
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Echinococcus granulosus c src tyrosine kinase 0.0136 0.9979 0.9979
Echinococcus multilocularis SH2 domain containing protein 7 0.006 0.3135 0.3142
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0097 0.6411 0.6425
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0059 0.3 0.3006
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Onchocerca volvulus 0.006 0.3135 0.0812
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0097 0.6411 1
Loa Loa (eye worm) STAT protein 0.006 0.3135 0.3142
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.9979 1
Brugia malayi SRC-1 0.0136 0.9979 1
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0059 0.3 0.3006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.164 0.1644
Onchocerca volvulus Serine\/threonine kinase homolog 0.0073 0.4288 0.7739
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.164 0.2348
Schistosoma mansoni hypothetical protein 0.006 0.3135 0.3142
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.3 0.3608
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0136 0.9979 1
Onchocerca volvulus 0.006 0.3135 0.0812
Loa Loa (eye worm) hypothetical protein 0.0119 0.8449 0.8467
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0059 0.3 0.3006
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.006 0.3135 0.3142
Schistosoma mansoni growth factor receptor-bound protein 0.0119 0.8449 0.8467
Schistosoma mansoni tensin-related 0.006 0.3135 0.3142
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0039 0.1159 0.1577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.193 0.5
Schistosoma mansoni tensin 0.006 0.3135 0.3142
Brugia malayi tRNA modification GTPase TrmE family protein 0.006 0.3135 0.3142
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0059 0.3 0.4529
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Schistosoma mansoni kinase 0.0037 0.1041 0.1043
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0039 0.1159 0.2391
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0073 0.4288 0.4297
Schistosoma mansoni vav2 0.006 0.3135 0.3142
Schistosoma mansoni cell polarity protein 0.0059 0.3 0.3006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0069 0.3885 0.3894
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0059 0.3 0.3
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0039 0.1159 0.1577
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0059 0.3 0.3006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.9979 0.9979
Echinococcus multilocularis c src tyrosine kinase 0.0136 0.9979 1
Brugia malayi Protein kinase domain containing protein 0.0077 0.4665 0.4675
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0097 0.6411 0.6411
Echinococcus granulosus expressed conserved protein 0.006 0.3135 0.3135
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0069 0.3885 0.3894
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.9979 1
Echinococcus granulosus tensin 0.006 0.3135 0.3135
Schistosoma mansoni tyrosine kinase 0.0136 0.9979 1
Brugia malayi hypothetical protein 0.0077 0.4665 0.4675
Entamoeba histolytica unconventional myosin IB 0.0059 0.3 0.4529
Schistosoma mansoni hypothetical protein 0.0059 0.3 0.3006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.164 0.2348
Onchocerca volvulus 0.0077 0.4665 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0077 0.4665 0.4675
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0059 0.3 0.3006
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Echinococcus granulosus tyrosine kinase 0.0077 0.4665 0.4665
Schistosoma mansoni tyrosine kinase 0.0136 0.9979 1
Brugia malayi Guanylate kinase family protein 0.0059 0.3 0.3006
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0028 0.0176 0.5
Schistosoma mansoni run and tbc1 domain containing 0.0059 0.3 0.3006
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Brugia malayi Spectrin alpha chain 0.0059 0.3 0.3006
Echinococcus multilocularis signal transduction protein lnk realted 0.006 0.3135 0.3142
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0954 0.1248
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.006 0.3135 0.3142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0096 0.6302 0.6316
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0073 0.4288 0.4297
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.006 0.3135 0.3142
Brugia malayi SH2 domain containing protein 0.0077 0.4665 0.4675
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0097 0.6411 0.6425
Echinococcus multilocularis expressed protein 0.0059 0.3 0.3006
Schistosoma mansoni eps8-related protein 0.0059 0.3 0.3006
Schistosoma mansoni signal transduction protein lnk-related 0.006 0.3135 0.3142
Trichomonas vaginalis p67phox protein, putative 0.0059 0.3 0.4529
Schistosoma mansoni tyrosine kinase 0.0136 0.9979 1
Entamoeba histolytica hypothetical protein 0.008 0.4947 0.7652
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0073 0.4288 0.4288
Echinococcus granulosus intersectin 2 0.0059 0.3 0.3
Brugia malayi SH2 domain containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis Zinc finger, PHD finger 0.0028 0.0176 0.0176
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0073 0.4288 1
Brugia malayi Protein kinase domain containing protein 0.0077 0.4665 0.4675
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.1074 0.1077
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.4947 0.4957
Onchocerca volvulus 0.0077 0.4665 1
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Echinococcus multilocularis suppressor of cytokine signaling 7 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.4288 0.6595
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0136 0.9979 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0136 0.9979 1
Echinococcus granulosus tyrosine kinase 0.0077 0.4665 0.4665
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0028 0.0176 0.0176
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0081 0.5 0.5011
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0096 0.6302 0.6316
Brugia malayi Protein kinase domain containing protein 0.0077 0.4665 0.4675
Loa Loa (eye worm) hypothetical protein 0.0028 0.0211 0.0212
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0039 0.1159 0.1162
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.6302 0.6302
Schistosoma mansoni formin binding protein and related proteins 0.0059 0.3 0.3006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.006 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Echinococcus granulosus tyrosine protein kinase Src64B 0.0136 0.9979 0.9979
Echinococcus granulosus tyrosine protein kinase shark 0.0077 0.4665 0.4665
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Echinococcus multilocularis 0.006 0.3135 0.3142
Loa Loa (eye worm) TK protein kinase 0.0077 0.4665 0.4675
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0119 0.8449 0.8467
Echinococcus granulosus tensin C1 domain containing phosphatase 0.006 0.3135 0.3135
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0097 0.6411 1
Brugia malayi SH2 domain containing protein 0.0077 0.4665 0.4675
Giardia lamblia Kinase, PLK 0.0073 0.4288 1
Onchocerca volvulus 0.0077 0.4665 1
Echinococcus granulosus epidermal growth factor receptor kinase 0.0059 0.3 0.3
Brugia malayi Myosin tail family protein 0.0059 0.3 0.3006
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.6302 0.6316
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Loa Loa (eye worm) p53BP2 0.0059 0.3 0.3006
Entamoeba histolytica serine/threonine protein kinase, putative 0.0073 0.4288 0.6595
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0136 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.2686 0.2692
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.164 0.2348
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Entamoeba histolytica hypothetical protein 0.0059 0.3 0.4529
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0059 0.3 0.3006
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0136 0.9979 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.006 0.3135 0.3142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.008 0.4947 0.7652
Echinococcus multilocularis growth factor receptor bound protein 2 0.0119 0.8449 0.8467
Echinococcus granulosus tyrosine protein kinase Blk 0.0077 0.4665 0.4665
Brugia malayi Variant SH3 domain containing protein 0.0059 0.3 0.3006
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.3 0.4529
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.1159 0.1577
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0136 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0097 0.6411 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0059 0.3 0.3006
Brugia malayi STAT protein, DNA binding domain containing protein 0.006 0.3135 0.3142
Loa Loa (eye worm) hypothetical protein 0.0059 0.3 0.3006
Brugia malayi Peripheral plasma membrane protein CASK 0.0059 0.3 0.3006
Brugia malayi Protein kinase domain containing protein 0.0077 0.4665 0.4675
Echinococcus multilocularis suppressor of cytokine signaling 6 0.006 0.3135 0.3142
Echinococcus granulosus expressed protein 0.0059 0.3 0.3
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.193 0.1934
Toxoplasma gondii aldehyde dehydrogenase 0.0047 0.193 1
Onchocerca volvulus 0.006 0.3135 0.0812
Brugia malayi SH3 domain containing protein 0.0059 0.3 0.3006
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0059 0.3 0.3608
Brugia malayi Variant SH3 domain containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis endophilin A3 0.0059 0.3 0.3006
Trypanosoma brucei polo-like protein kinase 0.0073 0.4288 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.2421 0.3601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.164 0.1644
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.3135 0.3142
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0059 0.3 0.3006
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.006 0.3135 0.3135
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.3135 0.3142
Loa Loa (eye worm) RhoGAP domain-containing protein 0.006 0.3135 0.3142
Brugia malayi protein-tyrosine kinase 0.0077 0.4665 0.4675
Loa Loa (eye worm) SH2 domain-containing protein 0.006 0.3135 0.3142
Schistosoma mansoni nck2/grb4 0.0119 0.8449 0.8467
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.4529 0.4539
Entamoeba histolytica protein kinase, putative 0.0061 0.3156 0.478
Echinococcus granulosus tyrosine protein kinase Src42A 0.0136 0.9979 0.9979
Schistosoma mansoni hypothetical protein 0.0059 0.3 0.3006
Loa Loa (eye worm) TK/FER protein kinase 0.0077 0.4665 0.4675
Onchocerca volvulus 0.0077 0.4665 1
Schistosoma mansoni adapter molecule crk 0.0119 0.8449 0.8467
Schistosoma mansoni C-fyn 0.0059 0.3 0.3006
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0136 0.9979 0.9979
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0039 0.1159 0.0159
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0059 0.3 0.3006
Brugia malayi RhoGAP domain containing protein 0.006 0.3135 0.3142
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0059 0.3 0.3006
Echinococcus granulosus SHC transforming protein 3 0.006 0.3135 0.3135
Echinococcus granulosus tyrosine protein kinase Src42A 0.006 0.3135 0.3135
Entamoeba histolytica BAR/SH3 domain containing protein 0.0059 0.3 0.4529
Echinococcus multilocularis tyrosine protein kinase Srms 0.0077 0.4665 0.4675
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0072 0.4166 0.6399
Echinococcus granulosus Spectrin alpha actinin 0.0059 0.3 0.3
Brugia malayi Variant SH3 domain containing protein 0.006 0.3135 0.3142
Brugia malayi Tensin 0.006 0.3135 0.3142

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 120 nM Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line ChEMBL. 14698200
IC50 (binding) = 120 nM Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line ChEMBL. 14698200

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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