Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | celfurPC protein | 0.0116 | 0.0472 | 0.0458 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0074 | 0.0267 | 0.0204 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0215 | 0.0954 | 0.0713 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0179 | 0.0779 | 0.0719 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0036 | 0.0082 | 0.0087 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.1899 | 0.9184 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.0023 | 0.0025 |
Echinococcus granulosus | adam 17 protease | 0.0074 | 0.0267 | 0.0204 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0056 | 0.0176 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0416 | 0.0401 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2066 | 1 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.0215 | 0.0954 | 0.0927 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0023 | 0.0025 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0003 | 0.0004 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0179 | 0.0779 | 0.0719 |
Loa Loa (eye worm) | metalloprotease | 0.0049 | 0.0146 | 0.0131 |
Echinococcus multilocularis | Furin 1 | 0.0034 | 0.0071 | 0.0006 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0696 | 0.3304 | 0.3261 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.0022 | 0.0006 |
Brugia malayi | proprotein convertase 2 | 0.0091 | 0.0347 | 0.0332 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.0031 | 0.0033 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0063 | 0.0211 | 0.0171 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0023 | 0.0024 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0231 | 0.1036 | 0.0999 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0115 | 0.0468 | 0.0453 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0003 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0065 | 0.0049 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.1899 | 0.9184 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0215 | 0.0954 | 0.0713 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.002 | 0.002 |
Echinococcus multilocularis | 0.0116 | 0.0472 | 0.041 | |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2066 | 1 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0117 | 0.0475 | 0.0413 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0065 | 0.0024 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.0129 | 0.0114 |
Echinococcus multilocularis | integrin alpha ps | 0.0068 | 0.0238 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0416 | 0.0401 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.1899 | 0.9184 | 1 |
Echinococcus granulosus | furin | 0.0144 | 0.0608 | 0.0547 |
Brugia malayi | Reprolysin | 0.0105 | 0.0417 | 0.0402 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0144 | 0.0608 | 0.057 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.0215 | 0.0954 | 0.0713 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0091 | 0.0347 | 0.0284 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0215 | 0.0954 | 0.0917 |
Brugia malayi | angiogenesis inhibito | 0.0105 | 0.0416 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0267 | 0.0252 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0234 | 0.1049 | 0.1012 |
Brugia malayi | hypothetical protein | 0.0046 | 0.013 | 0.0115 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0056 | 0.0176 | 0.0161 |
Echinococcus granulosus | integrin alpha ps | 0.0068 | 0.0238 | 0.0175 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0179 | 0.0779 | 0.0741 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Schistosoma mansoni | integrin alpha-ps | 0.0068 | 0.0238 | 0.0198 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.0031 | 0.0033 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0215 | 0.0954 | 0.0713 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0031 | 0.0033 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2066 | 1 | 1 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0215 | 0.0954 | 0.094 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0088 | 0.0332 | 0.027 |
Brugia malayi | hypothetical protein | 0.0234 | 0.1049 | 0.1035 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.1005 | 0.0947 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0074 | 0.0267 | 0.0227 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2066 | 1 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0779 | 0.0765 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0031 | 0.0033 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1273 | 0.6125 | 0.6109 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2066 | 1 | 1 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit beta | 0.0073 | 0.026 | 0.0283 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0003 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0176 | 0.0136 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0215 | 0.0954 | 0.0713 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.0023 | 0.0008 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0146 | 0.0131 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0215 | 0.0954 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0078 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0315 | 0.03 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0034 | 0.0071 | 0.0055 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0696 | 0.3304 | 0.3261 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0235 | 0.1052 | 0.1039 |
Brugia malayi | endoprotease bli-4 precursor | 0.0144 | 0.0608 | 0.0594 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0091 | 0.0347 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0489 | 0.0474 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0088 | 0.0332 | 0.0319 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.1005 | 0.0947 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.0031 | 0.0032 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0031 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.013 | 0.0115 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.0023 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0176 | 0.0136 |
Schistosoma mansoni | integrin alpha | 0.0152 | 0.0649 | 0.0611 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0036 | 0.0082 | 0.0089 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.0023 | 0.0024 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0046 | 0.013 | 0.0115 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0049 | 0.0146 | 0.0131 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0144 | 0.0608 | 0.0594 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0023 | 0.0025 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.002 | 0.002 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0074 | 0.0267 | 0.0204 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0304 | 0.139 | 0.1377 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2066 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0167 | 0.072 | 0.0784 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0034 | 0.0071 | 0.003 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0088 | 0.0332 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0181 | 0.0166 |
Brugia malayi | ribonucleotide reductase 2 | 0.0215 | 0.0954 | 0.094 |
Echinococcus multilocularis | integrin alpha ps | 0.0068 | 0.0238 | 0.0175 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2066 | 1 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2066 | 1 | 1 |
Schistosoma mansoni | ADAMTS14 peptidase (M12 family) | 0.0049 | 0.0146 | 0.0106 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0779 | 0.0742 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0683 | 0.3241 | 0.3528 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0088 | 0.0332 | 0.027 |
Brugia malayi | Disintegrin family protein | 0.0074 | 0.0267 | 0.0252 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0167 | 0.072 | 0.0784 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0215 | 0.0954 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0176 | 0.0161 |
Echinococcus multilocularis | adam | 0.0244 | 0.1097 | 0.1039 |
Echinococcus granulosus | adam | 0.0244 | 0.1097 | 0.1039 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0054 | 0.0166 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0215 | 0.0954 | 0.0713 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.1899 | 0.9184 | 1 |
Echinococcus granulosus | Furin 1 | 0.0034 | 0.0071 | 0.0006 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0215 | 0.0954 | 0.1038 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0091 | 0.0347 | 0.0284 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0105 | 0.0416 | 0.0401 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0167 | 0.072 | 0.0782 |
Schistosoma mansoni | integrin alpha-ps | 0.0036 | 0.0078 | 0.0038 |
Brugia malayi | Kelch motif family protein | 0.0046 | 0.013 | 0.0115 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0036 | 0.0082 | 0.0087 |
Loa Loa (eye worm) | reprolysin | 0.0179 | 0.0779 | 0.0765 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0056 | 0.0176 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0608 | 0.0594 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.0023 | 0.0025 |
Brugia malayi | metalloprotease | 0.0049 | 0.0146 | 0.0131 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2066 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0583 | 0.2751 | 0.1987 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) | 0.0073 | 0.026 | 0.0283 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2066 | 1 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0215 | 0.0954 | 0.0896 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0056 | 0.0176 | 0.0112 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0215 | 0.0954 | 0.1038 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0152 | 0.0649 | 0.0635 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.0031 | 0.0032 |
Echinococcus granulosus | integrin alpha 3 | 0.0117 | 0.0475 | 0.0413 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0174 | 0.0159 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0023 | 0.0025 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0074 | 0.0267 | 0.0204 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0023 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0176 | 0.0136 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0074 | 0.0267 | 0.0204 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0056 | 0.0176 | 0.0161 |
Brugia malayi | ADAMTS-like protease | 0.0105 | 0.0416 | 0.0401 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0104 | 0.0089 |
Onchocerca volvulus | 0.0042 | 0.0111 | 0.9285 | |
Schistosoma mansoni | apoptosis regulator bax | 0.0056 | 0.0176 | 0.0136 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0034 | 0.0071 | 0.0033 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.1899 | 0.9184 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0304 | 0.139 | 0.1377 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0003 | 0.0002 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.0118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0468 | 0.0453 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.0023 | 0.0024 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0179 | 0.0779 | 0.0741 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0036 | 0.0082 | 0.0089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 uM | Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase | ChEMBL. | 2153817 |
Inhibition (binding) | = 91 % | Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM | ChEMBL. | 2153817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.