Detailed information for compound 26194

Basic information

Technical information
  • TDR Targets ID: 26194
  • Name: (E)-3-(4-fluorophenyl)-N-methyl-N-(naphthalen -1-ylmethyl)prop-2-en-1-amine
  • MW: 305.389 | Formula: C21H20FN
  • H donors: 0 H acceptors: 0 LogP: 5.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1cccc2c1cccc2)C/C=C/c1ccc(cc1)F
  • InChi: 1S/C21H20FN/c1-23(15-5-6-17-11-13-20(22)14-12-17)16-19-9-4-8-18-7-2-3-10-21(18)19/h2-14H,15-16H2,1H3/b6-5+
  • InChiKey: LGOJCTYWHXPMQJ-AATRIKPKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-(4-fluorophenyl)-N-methyl-N-(1-naphthylmethyl)prop-2-en-1-amine
  • (E)-3-(4-fluorophenyl)-N-methyl-N-(1-naphthalenylmethyl)-2-propen-1-amine
  • [(E)-3-(4-fluorophenyl)allyl]-methyl-(1-naphthylmethyl)amine
  • [(E)-3-(4-fluorophenyl)prop-2-enyl]-methyl-(1-naphthylmethyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0943 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0943 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0943 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.023 0.023
Schistosoma mansoni nuclear receptor 0.0445 0.4672 0.4672
Schistosoma mansoni nuclear hormone receptor 0.0943 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0078 0.0078
Schistosoma mansoni transcription factor btf3 0.0034 0.0277 0.0277
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0445 0.4672 0.4557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0943 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0445 0.4672 0.4672
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0943 1 1
Onchocerca volvulus Glutamine synthetase homolog 0.0494 0.5205 0.5101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0213
Schistosoma mansoni nuclear hormone receptor 0.0445 0.4672 0.4672
Plasmodium falciparum glutamine synthetase, putative 0.0494 0.5205 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Brugia malayi nuclear hormone receptor family member odr-7 0.0445 0.4672 0.4663
Echinococcus granulosus GPCR family 2 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Brugia malayi nuclear receptor NHR-88 0.0943 1 1
Brugia malayi glutamine synthetase 0.0274 0.285 0.2837
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0494 0.5205 1
Schistosoma mansoni cpg binding protein 0.0029 0.0229 0.0229
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0078 0.0078
Loa Loa (eye worm) nuclear hormone receptor 0.0445 0.4672 0.4662
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1461 0.1461
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus FTZ F1 alpha 0.0943 1 1
Brugia malayi Nuclear hormone receptor E75 0.0445 0.4672 0.4663
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Loa Loa (eye worm) nuclear receptor NHR-67 0.0445 0.4672 0.4662
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4148 0.4148
Brugia malayi hypothetical protein 0.0445 0.4672 0.4663
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0943 1 1
Onchocerca volvulus 0.0445 0.4672 0.4557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0943 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0943 1 1
Trypanosoma brucei glutamine synthetase, putative 0.0769 0.8139 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0498 0.5243 0.5243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Brugia malayi Pre-SET motif family protein 0.0029 0.023 0.0214
Onchocerca volvulus Protein ultraspiracle homolog 0.0943 1 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0078 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus transcription factor btf3 0.0034 0.0277 0.0277
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0431 0.0414
Brugia malayi Nuclear hormone receptor-like 1 0.0498 0.5243 0.5235
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Echinococcus multilocularis glutamine synthetase 0.0769 0.8139 0.8139
Plasmodium vivax glutamine synthetase, putative 0.0494 0.5205 1
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.199 0.199
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.025
Schistosoma mansoni coup transcription factor 0.0943 1 1
Echinococcus granulosus neuropeptide s receptor 0.0447 0.4701 0.4701
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0078 0.006
Echinococcus granulosus thyroid hormone receptor alpha 0.0445 0.4672 0.4672
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8139 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Schistosoma mansoni cpg binding protein 0.0028 0.0212 0.0212
Onchocerca volvulus Bile acid receptor homolog 0.0943 1 1
Brugia malayi nuclear receptor NHR-88 0.0445 0.4672 0.4663
Trichomonas vaginalis set domain proteins, putative 0.023 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0277 0.0387
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0277 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0943 1 1
Echinococcus granulosus glutamine synthetase 0.0769 0.8139 0.8139
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0078 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0489 0.0802
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.8307 0.8307
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0445 0.4672 0.4672
Schistosoma mansoni hypothetical protein 0.0396 0.4148 0.4148
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0078 0.0061
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0431 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0943 1 1
Brugia malayi beta-NAC-like protein 0.0034 0.0277 0.026
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0445 0.4672 0.4672
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0431 0.0414
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0943 1 1
Leishmania major glutamine synthetase, putative 0.0769 0.8139 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0078 0.0078
Mycobacterium ulcerans glutamine synthetase 0.0494 0.5205 1
Brugia malayi hypothetical protein 0.0498 0.5243 0.5235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0943 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4148 0.4148
Loa Loa (eye worm) hypothetical protein 0.0048 0.0431 0.0413
Schistosoma mansoni zinc finger protein 0.0445 0.4672 0.4672
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0494 0.5205 0.5
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0494 0.5205 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0194 0.199 0.373
Brugia malayi nuclear hormone receptor 0.0445 0.4672 0.4663
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0212 0.0194
Schistosoma mansoni cpg binding protein 0.0029 0.0229 0.0229
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8139 1
Onchocerca volvulus 0.0943 1 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0277 0.0387
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.199 0.199
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.4701 0.4701
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0194 0.199 0.5
Brugia malayi hypothetical protein 0.0445 0.4672 0.4663
Brugia malayi conserved hypotetical protein 0.0445 0.4672 0.4663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Brugia malayi Nuclear hormone receptor-like 1 0.0943 1 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0277 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0943 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0943 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0445 0.4672 0.4672
Brugia malayi nuclear hormone receptor 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0943 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0943 1 1
Brugia malayi nuclear receptor RXR 0.0498 0.5243 0.5235
Brugia malayi Pre-SET motif family protein 0.0202 0.2075 0.2062
Onchocerca volvulus 0.0445 0.4672 0.4557
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.1669
Echinococcus multilocularis transcription factor btf3 0.0034 0.0277 0.0277
Leishmania major basic transcription factor 3a, putative 0.0034 0.0277 0.0246
Schistosoma mansoni thyroid hormone receptor 0.0943 1 1
Brugia malayi tailless protein 0.0445 0.4672 0.4663
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0445 0.4672 0.4672
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0943 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Brugia malayi photoreceptor-specific nuclear receptor 0.0943 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0943 1 1
Onchocerca volvulus 0.0029 0.023 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0943 1 1
Brugia malayi nuclear receptor RXR 0.0445 0.4672 0.4663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0943 1 1
Loa Loa (eye worm) DR-78 0.0445 0.4672 0.4662
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.023 0.023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0078 0.0078
Brugia malayi steroid hormone receptor 0.0943 1 1
Loa Loa (eye worm) Gln-2 protein 0.0494 0.5205 0.5196
Brugia malayi Nuclear hormone receptor E75 0.0445 0.4672 0.4663
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0145 0.1461 0.1445
Schistosoma mansoni nuclear receptor nhr-48 0.0445 0.4672 0.4672
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0943 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0078 0.0061
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis geminin 0.0164 0.1669 0.1669
Schistosoma mansoni nuclear receptor 0.0445 0.4672 0.4672
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0078 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0943 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.023 0.0296
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0277 0.0246
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0267 0.0251
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0445 0.4672 0.4557
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0943 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0943 1 1
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.199 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0943 1 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0494 0.5205 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Plasmodium vivax SET domain protein, putative 0.0029 0.023 0.0296
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0445 0.4672 0.4663
Brugia malayi CXXC zinc finger family protein 0.0028 0.0212 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0445 0.4672 0.4672
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0943 1 1
Brugia malayi nuclear receptor NHR-67 0.0445 0.4672 0.4663
Brugia malayi nuclear hormone receptor family member nhr-6 0.0445 0.4672 0.4663
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0212 0.0212
Echinococcus multilocularis muscleblind protein 0.0145 0.1461 0.1461
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0943 1 1
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.199 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1461 0.1445
Loa Loa (eye worm) steroid hormone receptor 0.0943 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0943 1 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0229 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0445 0.4672 0.4672
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0943 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0445 0.4672 0.4672
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0943 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.4701 0.4701
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0498 0.5243 0.5243
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0943 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.023 0.023
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0194 0.199 0.8175
Brugia malayi ecdysone receptor 0.0445 0.4672 0.4663
Trichomonas vaginalis glutamine synthetase, putative 0.0194 0.199 0.8175
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0943 1 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0078 0.0078
Brugia malayi hypothetical protein 0.0498 0.5243 0.5235
Echinococcus multilocularis thyroid hormone receptor alpha 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus ecdysone induced protein 78C 0.0943 1 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.0078 0.0061
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.023 0.023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0267 0.0267
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0769 0.8139 0.8139
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0498 0.5243 0.5243
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Schistosoma mansoni RAR-like nuclear receptor 0.0943 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0943 1 1
Echinococcus granulosus cpg binding protein 0.0029 0.0229 0.0229
Schistosoma mansoni retinoic acid receptor RXR 0.0943 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0943 1 1
Brugia malayi Muscleblind-like protein 0.0145 0.1461 0.1446
Onchocerca volvulus 0.023 0.2373 0.2208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Brugia malayi orphan nuclear receptor NR2E1 0.0445 0.4672 0.4663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0943 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0498 0.5243 0.5234
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.4701 0.4701
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0943 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0498 0.5243 0.5243
Echinococcus granulosus muscleblind protein 0.0145 0.1461 0.1461
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2075 0.2061
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0943 1 1
Echinococcus granulosus geminin 0.0164 0.1669 0.1669
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0445 0.4672 0.4662
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0078 0.0078
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0277 0.0387
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0498 0.5243 0.5235
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0445 0.4672 0.4672

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 21 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 0.1% ChEMBL. 3510297
Activity (functional) = 82 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 0.5% ChEMBL. 3510297
Activity (functional) = 100 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 2% ChEMBL. 3510297
MIC (functional) = 0.1 ug ml-1 Antifungal activity measured against Trichophyton mentagrophytes ChEMBL. 3510297
MIC (functional) = 0.1 ug ml-1 Antifungal activity against Epidermophyton floccosum. ChEMBL. 3510297
MIC (functional) = 0.2 ug ml-1 Antifungal activity against Microsporum canis ChEMBL. 3510297
MIC (functional) = 1.6 ug ml-1 Antifungal activity measured against Sporothrix schenck ii. ChEMBL. 3510297
MIC (functional) = 3.1 ug ml-1 Antifungal activity against Candida parapsilosis. ChEMBL. 3510297
MIC (functional) = 25 ug ml-1 Antifungal activity measured against Aspergillus fumigatus ChEMBL. 3510297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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