Detailed information for compound 26198

Basic information

Technical information
  • TDR Targets ID: 26198
  • Name: 2-[[amino(hydrazinyl)methylidene]amino]acetic acid
  • MW: 132.121 | Formula: C3H8N4O2
  • H donors: 4 H acceptors: 2 LogP: -3.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=N)NCC(=O)O
  • InChi: 1S/C3H8N4O2/c4-3(7-5)6-1-2(8)9/h1,5H2,(H,8,9)(H3,4,6,7)
  • InChiKey: XJHZGOPHYCNIAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[amino(hydrazino)methylene]amino]acetic acid
  • 2-[[azanyl(hydrazinyl)methylidene]amino]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0439 0.5237 0.5228
Echinococcus multilocularis ecdysone induced protein 78C 0.083 1 1
Brugia malayi conserved hypotetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni Tr4/Tr2 (homologue) 0.083 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus glutamine synthetase 0.0773 0.9297 0.9297
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0497 0.5945 1
Schistosoma mansoni transcription factor btf3 0.0034 0.0316 0.0316
Brugia malayi nuclear hormone receptor 0.083 1 1
Loa Loa (eye worm) Gln-2 protein 0.0497 0.5945 0.5936
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.083 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Echinococcus granulosus cpg binding protein 0.003 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0316 0.0387
Schistosoma mansoni hypothetical protein 0.0165 0.1907 0.1907
Schistosoma mansoni steroid hormone receptor ad4bp 0.083 1 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0089 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0089 0.0069
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0263 0.0263
Brugia malayi Nuclear hormone receptor E75 0.0392 0.4666 0.4655
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0492 0.0474
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0392 0.4666 0.4655
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0263 0.0263
Loa Loa (eye worm) nuclear receptor NHR-67 0.0392 0.4666 0.4655
Onchocerca volvulus Protein ultraspiracle homolog 0.083 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Brugia malayi nuclear receptor NHR-88 0.0392 0.4666 0.4655
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Brugia malayi orphan nuclear receptor NR2E1 0.0392 0.4666 0.4655
Brugia malayi nuclear receptor RXR 0.0392 0.4666 0.4655
Brugia malayi Nuclear hormone receptor family member nhr-19 0.083 1 1
Loa Loa (eye worm) DR-78 0.0392 0.4666 0.4655
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0392 0.4666 0.4666
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0089 0.0089
Brugia malayi nuclear hormone receptor family member nhr-6 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.0243
Brugia malayi CXXC zinc finger family protein 0.0028 0.0242 0.0223
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Onchocerca volvulus 0.083 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0439 0.5237 0.5228
Loa Loa (eye worm) hypothetical protein 0.0145 0.167 0.1652
Onchocerca volvulus Glutamine synthetase homolog 0.0497 0.5945 0.5844
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.083 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0439 0.5237 0.5237
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.083 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.083 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0392 0.4666 0.4533
Brugia malayi Steroid receptor seven-up type 2 0.083 1 1
Brugia malayi beta-NAC-like protein 0.0034 0.0316 0.0297
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0089 0.0089
Brugia malayi Pre-SET motif family protein 0.003 0.0263 0.0244
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0392 0.4666 0.4666
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Brugia malayi Muscleblind-like protein 0.0145 0.167 0.1653
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.083 1 1
Schistosoma mansoni nuclear receptor 0.0392 0.4666 0.4666
Echinococcus multilocularis neuropeptide s receptor 0.045 0.5372 0.5372
Brugia malayi ecdysone receptor 0.0392 0.4666 0.4655
Brugia malayi Nuclear hormone receptor family member nhr-31 0.083 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.083 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0089 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0089 0.0069
Brugia malayi hypothetical protein 0.0439 0.5237 0.5228
Loa Loa (eye worm) nuclear hormone receptor 0.0392 0.4666 0.4655
Entamoeba histolytica glutamine synthetase, putative 0.0195 0.2273 1
Echinococcus granulosus nuclear receptor nhr 48 0.0392 0.4666 0.4666
Echinococcus granulosus Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0497 0.5945 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0439 0.5237 0.5237
Leishmania major glutamine synthetase, putative 0.0773 0.9297 1
Echinococcus granulosus neuropeptide s receptor 0.045 0.5372 0.5372
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Echinococcus multilocularis FTZ F1 alpha 0.083 1 1
Trichomonas vaginalis glutamine synthetase, putative 0.0195 0.2273 0.8169
Onchocerca volvulus 0.0392 0.4666 0.4533
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0316 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-1 0.083 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.083 1 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0089 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0263 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0089 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0392 0.4666 0.4666
Loa Loa (eye worm) steroid hormone receptor 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni glutamine synthetase bacteria 0.0195 0.2273 0.2273
Echinococcus granulosus ecdysone induced protein 78C 0.083 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0306 0.0306
Echinococcus multilocularis muscleblind protein 0.0145 0.167 0.167
Schistosoma mansoni hypothetical protein 0.0398 0.4741 0.4741
Brugia malayi Nuclear hormone receptor family member nhr-14 0.083 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0089 0.0069
Entamoeba histolytica glutamine synthetase, putative 0.0195 0.2273 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Schistosoma mansoni nuclear receptor 0.0392 0.4666 0.4666
Schistosoma mansoni cpg binding protein 0.0028 0.0242 0.0242
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0439 0.5237 0.5227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.083 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.083 1 1
Echinococcus granulosus geminin 0.0165 0.1907 0.1907
Echinococcus multilocularis geminin 0.0165 0.1907 0.1907
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0316 0.0387
Brugia malayi Nuclear hormone receptor-like 1 0.083 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0392 0.4666 0.4533
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.083 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.083 1 1
Schistosoma mansoni zinc finger protein 0.0392 0.4666 0.4666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.083 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0089 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0636 0.0636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0392 0.4666 0.4666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.083 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Brugia malayi Pre-SET motif family protein 0.0203 0.2372 0.2357
Brugia malayi hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus muscleblind protein 0.0145 0.167 0.167
Echinococcus multilocularis transcription factor btf3 0.0034 0.0316 0.0316
Brugia malayi nuclear receptor NHR-88 0.083 1 1
Schistosoma mansoni nuclear hormone receptor 0.0392 0.4666 0.4666
Plasmodium falciparum glutamine synthetase, putative 0.0497 0.5945 1
Schistosoma mansoni nuclear hormone receptor 0.083 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.083 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.0246
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Trypanosoma cruzi glutamine synthetase, putative 0.0773 0.9297 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.083 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.5372 0.5372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.083 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0439 0.5237 0.5237
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4741 0.4741
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Plasmodium vivax SET domain protein, putative 0.003 0.0263 0.0297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Echinococcus multilocularis glutamine synthetase 0.0773 0.9297 0.9297
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Trypanosoma brucei glutamine synthetase, putative 0.0773 0.9297 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.167 0.1652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0316 0.0296
Echinococcus granulosus transcription factor btf3 0.0034 0.0316 0.0316
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.083 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.083 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.083 1 1
Onchocerca volvulus 0.0392 0.4666 0.4533
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0262
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.0246
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0243 0.0243
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Onchocerca volvulus Bile acid receptor homolog 0.083 1 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.167 0.167
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Echinococcus granulosus neuropeptide receptor A26 0.045 0.5372 0.5372
Onchocerca volvulus 0.0231 0.2712 0.2531
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.083 1 1
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0773 0.9297 0.9297
Brugia malayi glutamine synthetase 0.0276 0.3255 0.3242
Brugia malayi hypothetical protein 0.0439 0.5237 0.5228
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0089 0.0089
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.9494 0.9494
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0242 0.0222
Schistosoma mansoni thyroid hormone receptor 0.083 1 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2712 1
Trypanosoma cruzi glutamine synthetase, putative 0.0773 0.9297 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4741 0.4741
Echinococcus multilocularis cpg binding protein 0.003 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.083 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.083 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0392 0.4666 0.4655
Echinococcus granulosus FTZ F1 alpha 0.083 1 1
Schistosoma mansoni glutamine synthetase bacteria 0.0195 0.2273 0.2273
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0195 0.2273 0.373
Brugia malayi nuclear hormone receptor family member odr-7 0.0392 0.4666 0.4655
Echinococcus granulosus thyroid hormone receptor alpha 0.0392 0.4666 0.4666
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0195 0.2273 0.5
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0392 0.4666 0.4666
Loa Loa (eye worm) hypothetical protein 0.0048 0.0492 0.0473
Brugia malayi photoreceptor-specific nuclear receptor 0.083 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0439 0.5237 0.5237
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0089 0.007
Brugia malayi tailless protein 0.0392 0.4666 0.4655
Brugia malayi nuclear hormone receptor 0.0392 0.4666 0.4655
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.083 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2372 0.2356
Brugia malayi Nuclear hormone receptor family member nhr-49 0.083 1 1
Brugia malayi hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.083 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.083 1 1
Schistosoma mansoni thyroid hormone receptor 0.083 1 1
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0262
Brugia malayi isocitrate dehydrogenase 0.0015 0.0089 0.007
Echinococcus multilocularis nuclear receptor nhr 48 0.0392 0.4666 0.4666
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0559 0.0802
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0392 0.4666 0.4666
Loa Loa (eye worm) hypothetical protein 0.0033 0.0306 0.0286
Schistosoma mansoni nuclear hormone receptor 0.0392 0.4666 0.4666
Toxoplasma gondii glutamine synthetase, type I, putative 0.0497 0.5945 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0316 0.0246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.083 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0492 0.0474
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0492 0.0473
Brugia malayi steroid hormone receptor 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.1907 0.1907
Plasmodium vivax glutamine synthetase, putative 0.0497 0.5945 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0497 0.5945 1
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0439 0.5237 0.5228
Schistosoma mansoni nuclear receptor nhr-48 0.0392 0.4666 0.4666
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0263 0.0297
Schistosoma mansoni coup transcription factor 0.083 1 1
Brugia malayi nuclear receptor NHR-67 0.0392 0.4666 0.4655
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0089 0.007
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0316 0.0387
Mycobacterium ulcerans glutamine synthetase 0.0497 0.5945 1
Brugia malayi Nuclear hormone receptor E75 0.0392 0.4666 0.4655
Schistosoma mansoni RAR-like nuclear receptor 0.083 1 1
Onchocerca volvulus 0.003 0.0263 0.0021
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.083 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.083 1 1
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0195 0.2273 0.8169
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0392 0.4666 0.4666
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Echinococcus granulosus GPCR family 2 0.0015 0.0089 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0306 0.0287
Echinococcus multilocularis thyroid hormone receptor alpha 0.083 1 1

Activities

Activity type Activity value Assay description Source Reference
Blood glucose (functional) = 97 mg dl-1 Terminal blood glucose level was determined in ob/ob mice after oral administration for two weeks(control=226+/-29) ChEMBL. 11312923
Blood glucose (functional) = 97 mg dl-1 Terminal blood glucose level was determined in ob/ob mice after oral administration for two weeks(control=226+/-29) ChEMBL. 11312923
Blood glucose (functional) = 227 mg dl-1 Initial blood glucose level was determined in ob/ob mice(control=228+/-19) ChEMBL. 11312923
Blood glucose (functional) = 227 mg dl-1 Initial blood glucose level was determined in ob/ob mice(control=228+/-19) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal lean body weight was determined in ob/ob mice after oral administration for two weeks(control=25+/-1) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal fat body weight was determined in ob/ob mice after oral administration for two weeks(control=28+/-0.9) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal lean body weight was determined in ob/ob mice after oral administration for two weeks(control=25+/-1) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal fat body weight was determined in ob/ob mice after oral administration for two weeks(control=28+/-0.9) ChEMBL. 11312923
Body weight (functional) = 46 g Terminal body weight was determined in ob/ob mice after oral administration for two weeks(control=53+/-1) ChEMBL. 11312923
Body weight (functional) = 46 g Terminal body weight was determined in ob/ob mice after oral administration for two weeks(control=53+/-1) ChEMBL. 11312923
Body weight (functional) = 52 g Initial body weight was determined in ob/ob mice(control=55+/-1) ChEMBL. 11312923
Body weight (functional) = 52 g Initial body weight was determined in ob/ob mice(control=55+/-1) ChEMBL. 11312923
Dose (functional) = 436 mg kg-1 Avarage daily dose was determined in ob/ob mice(control=0) ChEMBL. 11312923
Dose (functional) = 436 mg kg-1 Avarage daily dose was determined in ob/ob mice(control=0) ChEMBL. 11312923
Food intake (functional) = 87 g kg-1 Average daily food consumption was determined in ob/ob mice after oral administration for twoweeks(control=90+/-3) ChEMBL. 11312923
Food intake (functional) = 87 g kg-1 Average daily food consumption was determined in ob/ob mice after oral administration for twoweeks(control=90+/-3) ChEMBL. 11312923
MISS T/C (functional) < 0.51 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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