Detailed information for compound 263051

Basic information

Technical information
  • TDR Targets ID: 263051
  • Name: 4-oxo-4-(phenethylamino)butanoic acid
  • MW: 221.252 | Formula: C12H15NO3
  • H donors: 2 H acceptors: 3 LogP: 0.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCC(=O)O)NCCc1ccccc1
  • InChi: 1S/C12H15NO3/c14-11(6-7-12(15)16)13-9-8-10-4-2-1-3-5-10/h1-5H,6-9H2,(H,13,14)(H,15,16)
  • InChiKey: ZMYKITJYWFYRFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-keto-4-(phenethylamino)butyric acid
  • 4-oxo-4-(2-phenylethylamino)butanoic acid
  • 4-keto-4-(2-phenylethylamino)butyric acid
  • [2-(Succinylamino)ethyl]polystyrene
  • ST5446014
  • 81539_FLUKA
  • 81536_FLUKA
  • Polystyrene A-COOH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0518 0.0518
Loa Loa (eye worm) fibroinase 0.0078 0.1695 0.1695
Toxoplasma gondii preprocathepsin c precursor, putative 0.003 0.0542 0.1204
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0152 0.3467 0.3373
Schistosoma mansoni hypothetical protein 0.0037 0.0706 0.0706
Trypanosoma brucei oligopeptidase b 0.0052 0.1065 0.2777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.1695 0.1576
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0542 0.0406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Schistosoma mansoni ferritin 0.0008 0.0008 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.1695 0.1695
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1142 0.1142
Toxoplasma gondii exonuclease III APE 0.0019 0.0266 0.0373
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0542 0.0542
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0198 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0542 0.1544
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.003 0.0542 0.1544
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.1695 0.1695
Plasmodium falciparum serine repeat antigen 7 0.003 0.0542 0.2578
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.003 0.0542 0.1204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0888 0.0888
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Plasmodium vivax vivapain-2 0.0078 0.1695 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Loa Loa (eye worm) hypothetical protein 0.0146 0.3338 0.3338
Onchocerca volvulus 0.0078 0.1695 0.4859
Leishmania major hypothetical protein, conserved 0.0025 0.042 0.0838
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.042 0.1795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0542 0.0542
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1238 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.003 0.0542 0.2578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.1695 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.1065 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.003 0.0542 0.2578
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0141 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0198 0.0198
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2589 0.2589
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0542 0.0542
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.003 0.0542 0.2578
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.1695 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Onchocerca volvulus 0.0078 0.1695 0.4859
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0542 0.2578
Plasmodium vivax unspecified product 0.003 0.0542 0.2578
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0266 0.0799
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.1695 0.1695
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0542 0.2578
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0542 0.1544
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0542 0.0542
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0542 0.2578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0542 0.0542
Giardia lamblia Cathepsin L-like protease 0.003 0.0542 0.1204
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0141 0.0141
Schistosoma mansoni ferritin 0.0008 0.0008 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.1695 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0518 0.0518
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0542 0.0542
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0331 0.1222
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.0542 0.1204
Plasmodium falciparum serine repeat antigen 6 0.003 0.0542 0.2578
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.1695 0.1576
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.003 0.0542 0.2578
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Toxoplasma gondii cathepsin CPC1 0.003 0.0542 0.1204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0542 0.1544
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.042 0.0283
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0141 0.0141
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0141 0.0141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Onchocerca volvulus 0.0029 0.0515 0.1169
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.1065 0.2777
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0542 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0888 0.0888
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.1065 0.4025
Brugia malayi RNA, U transporter 1 0.0084 0.1823 0.1823
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0266 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0266 0.0799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 1 1
Echinococcus granulosus expressed protein 0.0008 0.0008 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1034 0.1034
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.0542 0.1204
Giardia lamblia Cathepsin B precursor 0.003 0.0542 0.1204
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0331 0.0193
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0266 0.0266
Giardia lamblia Cathepsin B precursor 0.0152 0.3467 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0198 0.0198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0888 0.0888
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0266 0.0744
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0078 0.1695 0.1576
Echinococcus granulosus cathepsin L 0.003 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.3467 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.2965 0.2965
Plasmodium falciparum serine repeat antigen 4 0.003 0.0542 0.2578
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0266 1
Echinococcus granulosus prolyl endopeptidase 0.0131 0.2965 0.2965
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.1065 0.2777
Loa Loa (eye worm) hypothetical protein 0.0025 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0078 0.1695 0.1695
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.003 0.0542 0.0542
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.2965 0.2864
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0888 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Schistosoma mansoni cathepsin B (C01 family) 0.003 0.0542 0.0542
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.1695 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0084 0.0084
Onchocerca volvulus 0.0078 0.1695 0.4859
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.003 0.0542 0.0542
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.0029
Echinococcus multilocularis geminin 0.0173 0.3968 0.3968
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0542 0.2578
Schistosoma mansoni hypothetical protein 0.0173 0.3968 0.3968
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1034 0.1034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0706 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.1695 0.4876
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0384 0.0246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0266 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0515 0.0515
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Echinococcus granulosus cathepsin l1 0.0078 0.1695 0.1695
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.0542 0.1204
Giardia lamblia Cysteine protease 0.003 0.0542 0.1204
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0542 0.0406
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.1238 0.1238
Plasmodium vivax vivapain-1 0.003 0.0542 0.2578
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.042 0.1795
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0198 0.0198
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0542 0.0542
Giardia lamblia Cysteine protease 0.003 0.0542 0.1204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0016 0.0198 0.0198
Schistosoma mansoni ferritin light chain 0.0008 0.0008 0.0008
Brugia malayi cathepsin L precursor 0.003 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Schistosoma mansoni cpg binding protein 0.0031 0.0555 0.0555
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0542 0.0542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1305 0.1305
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0706 0.0706
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0331 0.0331
Onchocerca volvulus 0.0078 0.1695 0.4859
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0141 0.0141
Echinococcus multilocularis cysteine protease 0.0078 0.1695 0.1695
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0266 0.2093
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.1238 0.3298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0888 0.0888
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Giardia lamblia Cathepsin B precursor 0.0152 0.3467 1
Echinococcus multilocularis cathepsin b 0.0423 1 1
Plasmodium falciparum serine repeat antigen 3 0.003 0.0542 0.2578
Echinococcus granulosus cathepsin L 0.003 0.0542 0.0542
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1146 0.3019
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.003 0.0542 0.1544
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0141 0.0386
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0198 0.0198
Entamoeba histolytica hypothetical protein 0.0037 0.0706 0.3634
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.1695 0.1576
Plasmodium vivax vivapain-2 0.0078 0.1695 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0331 0.0193
Onchocerca volvulus 0.0146 0.3338 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0331 0.0571
Entamoeba histolytica cysteine proteinase 2 0.003 0.0542 0.2578
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0331 0.0331
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.1695 0.1576
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0384 0.1088
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0542 0.0406
Brugia malayi cathepsin F-like cysteine proteinase 0.003 0.0542 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0518 0.1133
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.2965 0.8831
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0542 0.0542
Onchocerca volvulus 0.0078 0.1695 0.4859
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0542 0.2578
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.1695 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0888 0.0888
Schistosoma mansoni hypothetical protein 0.0011 0.0084 0.0084
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0014 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0035 0.0647 0.0647
Brugia malayi hypothetical protein 0.0037 0.0706 0.0706
Giardia lamblia Hypothetical protein 0.003 0.0542 0.1204
Loa Loa (eye worm) ctsf protein 0.0078 0.1695 0.1695
Echinococcus granulosus geminin 0.0173 0.3968 0.3968
Schistosoma mansoni importin beta-1 0.0029 0.0518 0.0518
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.003 0.0542 0.2578
Entamoeba histolytica hypothetical protein 0.0037 0.0706 0.3634
Leishmania major oligopeptidase b 0.0052 0.1065 0.2777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0384 0.1088
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0542 0.2578
Schistosoma mansoni ferritin 0.0008 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.0647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0542 0.0542
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0152 0.3467 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.042 0.1795
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0647 0.0647
Echinococcus multilocularis expressed protein 0.0008 0.0008 0.0008
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.1065 0.2777
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.1695 0.1695
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.7363 0.7363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0384 0.1088
Trypanosoma brucei prolyl endopeptidase 0.0131 0.2965 0.8489
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.1695 0.1695
Leishmania major importin beta-1 subunit, putative 0.0024 0.0384 0.073
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.042 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0266 0.0373
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Schistosoma mansoni cathepsin C 0.003 0.0542 0.0542
Brugia malayi fibroinase precursor 0.003 0.0542 0.0542
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0331 0.0331
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0266 0.0981
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Onchocerca volvulus 0.003 0.0542 0.1253
Onchocerca volvulus Cathepsin L homolog 0.0078 0.1695 0.4859
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1238 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.1695 0.1695
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0141 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0542 0.1204
Brugia malayi cathepsin L-like cysteine proteinase 0.003 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0331 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Brugia malayi hypothetical protein 0.0025 0.042 0.042
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0542 0.2578
Plasmodium falciparum importin beta, putative 0.0029 0.0518 0.2425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0084 0.0084
Trypanosoma cruzi oligopeptidase b 0.0052 0.1065 0.0937
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Loa Loa (eye worm) hypothetical protein 0.0051 0.1034 0.1034
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0518 0.1133
Schistosoma mansoni cpg binding protein 0.0029 0.0515 0.0515
Echinococcus granulosus cathepsin b 0.0423 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0542 0.1544
Echinococcus multilocularis cysteine protease 0.0078 0.1695 0.1695
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.1238 0.4685
Schistosoma mansoni ferritin 0.0008 0.0008 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0542 0.1544
Toxoplasma gondii cathepsin B 0.0152 0.3467 1
Entamoeba histolytica hypothetical protein 0.0037 0.0706 0.3634
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0542 0.0542
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0542 0.0542
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0542 0.2578
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0014 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0078 0.1695 0.1695
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.1695 1
Toxoplasma gondii cathepsin CPL 0.0078 0.1695 0.4671
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0266 0.0373
Giardia lamblia Cathepsin B precursor 0.003 0.0542 0.1204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0266 0.0266
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0014 0.0141 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0542 0.1204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Trypanosoma cruzi oligopeptidase b 0.0052 0.1065 0.0937
Entamoeba histolytica hypothetical protein 0.0024 0.0384 0.1564
Schistosoma mansoni apoferritin-2 0.0008 0.0008 0.0008
Brugia malayi hypothetical protein 0.0016 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0078 0.1695 0.1695
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.042 0.0283
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.2965 0.8489
Echinococcus granulosus ferritin 0.0008 0.0008 0.0008
Brugia malayi cahepsin L-like non-peptiedase homolog 0.003 0.0542 0.0542
Schistosoma mansoni ran 0.0022 0.0331 0.0331
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0266 0.0744
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.1695 0.1695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.3467 0.3467
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.1695 0.4876
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1238 0.1238
Schistosoma mansoni apoferritin-2 0.0008 0.0008 0.0008
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0542 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0542 0.1544
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0266 0.0373
Plasmodium vivax unspecified product 0.003 0.0542 0.2578
Plasmodium falciparum serine repeat antigen 5 0.003 0.0542 0.2578
Onchocerca volvulus Cathepsin F homolog 0.0078 0.1695 0.4859
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0542 0.0406
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.2965 0.2965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Echinococcus multilocularis snurportin 1 0.0314 0.7363 0.7363
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0423 1 1
Onchocerca volvulus 0.0078 0.1695 0.4859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Onchocerca volvulus 0.0078 0.1695 0.4859
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.1695 0.1576
Entamoeba histolytica cysteine protease, putative 0.0078 0.1695 1
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.1695 0.1695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0888 0.0888
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0706 0.0706
Leishmania major cysteine peptidase A (CPA) 0.0078 0.1695 0.4671
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0014 0.0141 0.0141
Echinococcus granulosus snurportin 1 0.0314 0.7363 0.7363
Giardia lamblia Cathepsin B precursor 0.003 0.0542 0.1204
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.2634 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.003 0.0542 0.2578
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0266 0.0799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.1695 0.4876
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0266 0.0266
Echinococcus granulosus cathepsin b 0.0423 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0141 0.0141
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Mycobacterium tuberculosis Probable peptidase 0.0052 0.1065 0.4025
Schistosoma mansoni ap endonuclease 0.0019 0.0266 0.0266
Schistosoma mansoni ran 0.0022 0.0331 0.0331
Brugia malayi Cathepsin L-like cysteine proteinase 0.0078 0.1695 0.1695
Onchocerca volvulus Cathepsin L homolog 0.0078 0.1695 0.4859
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.042 0.0838
Toxoplasma gondii prolyl endopeptidase 0.0131 0.2965 0.8489
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1238 0.1238
Brugia malayi cathepsin L-like precursor 0.0078 0.1695 0.1695
Giardia lamblia Encystation-specific protease 0.003 0.0542 0.1204
Brugia malayi MH2 domain containing protein 0.0115 0.2589 0.2589
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.2965 0.2965
Schistosoma mansoni ferritin light chain 0.0008 0.0008 0.0008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0518 0.1133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Plasmodium vivax importin-beta 2, putative 0.0029 0.0518 0.2425
Echinococcus multilocularis ferritin 0.0008 0.0008 0.0008
Loa Loa (eye worm) cathepsin B 0.0152 0.3467 0.3467
Onchocerca volvulus Cathepsin L homolog 0.003 0.0542 0.1253
Echinococcus granulosus GPCR family 2 0.0016 0.0198 0.0198
Trichomonas vaginalis ran, putative 0.0022 0.0331 0.0935
Plasmodium falciparum serine repeat antigen 9 0.003 0.0542 0.2578
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2589 0.2589
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0141 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0542 0.0406
Loa Loa (eye worm) hypothetical protein 0.0423 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.1695 0.4671
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0014 0.0141 0.0141
Giardia lamblia Cathepsin B precursor 0.0152 0.3467 1
Loa Loa (eye worm) cysteine protease 0.0078 0.1695 0.1695
Onchocerca volvulus 0.0078 0.1695 0.4859
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.003 0.0542 0.2578
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.003 0.0542 0.2578
Trypanosoma brucei cysteine peptidase C (CPC) 0.0152 0.3467 1
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0542 0.2578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0542 0.1544
Brugia malayi hypothetical protein 0.0146 0.3338 0.3338
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0542 0.0542
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Echinococcus multilocularis cathepsin L 0.003 0.0542 0.0542
Schistosoma mansoni cpg binding protein 0.0031 0.0555 0.0555
Echinococcus granulosus Dipeptidyl peptidase 9 0.0014 0.0141 0.0141
Echinococcus multilocularis cathepsin b 0.0423 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0331 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0542 0.1544
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0423 1 1
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Entamoeba histolytica hypothetical protein 0.0037 0.0706 0.3634
Giardia lamblia Cathepsin B precursor 0.003 0.0542 0.1204
Entamoeba histolytica hypothetical protein 0.003 0.0542 0.2578
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.2965 0.2965
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.003 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Schistosoma mansoni hypothetical protein 0.0314 0.7363 0.7363
Giardia lamblia Cysteine protease 0.003 0.0542 0.1204
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.1695 0.1695
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0078 0.1695 0.1695
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.003 0.0542 0.2578
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.003 0.0542 0.2578
Giardia lamblia Cysteine protease 0.003 0.0542 0.1204
Plasmodium vivax vivapain-3 0.003 0.0542 0.2578
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0331 0.0331
Entamoeba histolytica Ran family GTPase 0.0022 0.0331 0.1222
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0542 0.1544
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.1065 0.8591
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.003 0.0542 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Giardia lamblia Cathepsin L-like protease 0.003 0.0542 0.1204
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.1695 0.1695
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.1695 0.1695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 1 1
Giardia lamblia Cathepsin B precursor 0.003 0.0542 0.1204
Leishmania major GTP-binding protein, putative 0.0022 0.0331 0.0571
Plasmodium falciparum serine repeat antigen 2 0.003 0.0542 0.2578
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0542 0.2578
Echinococcus granulosus cysteine protease 0.003 0.0542 0.0542
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0266 0.0126
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0141 0.0141
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.1065 0.0937
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.003 0.0542 0.1544
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0518 0.0518
Entamoeba histolytica cysteine protease, putative 0.003 0.0542 0.2578
Brugia malayi CXXC zinc finger family protein 0.0029 0.0515 0.0515
Giardia lamblia Cathepsin L precursor 0.003 0.0542 0.1204
Echinococcus multilocularis cathepsin L 0.003 0.0542 0.0542
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0141 0.0386
Echinococcus multilocularis GPCR, family 2 0.0016 0.0198 0.0198
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0331 0.0571
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1034 0.1034
Giardia lamblia Hypothetical protein 0.003 0.0542 0.1204
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.003 0.0542 0.2578
Loa Loa (eye worm) hypothetical protein 0.0131 0.2965 0.2965
Plasmodium falciparum serine repeat antigen 8 0.003 0.0542 0.2578
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0542 0.0542
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Echinococcus granulosus cpg binding protein 0.0031 0.0555 0.0555
Schistosoma mansoni ap endonuclease 0.0019 0.0266 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0542 0.2578
Echinococcus granulosus importin subunit beta 1 0.0029 0.0518 0.0518
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0542 0.2578
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Echinococcus multilocularis cpg binding protein 0.0031 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Toxoplasma gondii cathepsin CPC2 0.003 0.0542 0.1204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0888 0.0888
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0888 0.0888
Echinococcus granulosus cathepsin l1 0.0078 0.1695 0.1695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.1695 0.4876
Plasmodium falciparum serine repeat antigen 1 0.003 0.0542 0.2578
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.1065 0.0937
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.1695 0.1695
Brugia malayi Cathepsin L-like precursor 0.0078 0.1695 0.1695
Trypanosoma cruzi cysteine protease, putative 0.003 0.0542 0.0406
Leishmania major cathepsin L-like protease 0.0078 0.1695 0.4671
Schistosoma mansoni cathepsin S (C01 family) 0.003 0.0542 0.0542
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0173 0.3968 0.3968

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000078 M Inhibition of pig kidney aldose reductase (ALR2) ChEMBL. 14667216
IC50 (binding) = 0.000078 M Inhibition of pig kidney aldose reductase (ALR2) ChEMBL. 14667216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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