Detailed information for compound 264257

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.566 | Formula: C25H29NO6S
  • H donors: 1 H acceptors: 3 LogP: 3.1 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Oc1cc2CC[C@@H](c3c(c2c(c1OC)OC)ccc(c(=O)c3)SC)NC(=O)C
  • InChi: 1S/C25H29NO6S/c1-6-7-22(29)32-20-12-15-8-10-18(26-14(2)27)17-13-19(28)21(33-5)11-9-16(17)23(15)25(31-4)24(20)30-3/h9,11-13,18H,6-8,10H2,1-5H3,(H,26,27)/t18-/m0/s1
  • InChiKey: NXMUVIPICRBKOW-SFHVURJKSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin beta chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.634 0.6835
Echinococcus multilocularis peroxisome assembly protein 26 0.0012 0.0018 0.002
Plasmodium vivax hypothetical protein, conserved 0.0042 0.1136 1
Echinococcus multilocularis tubulin alpha chain 0.0012 0.0018 0.002
Schistosoma mansoni elongation factor 1-gamma 0.0014 0.0108 0.0108
Schistosoma mansoni alpha tubulin 0.0012 0.0018 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0499 0.43
Brugia malayi Tubulin beta-1 chain 0.003 0.0684 0.0719
Loa Loa (eye worm) hypothetical protein 0.0265 0.9275 1
Echinococcus granulosus tubulin alpha chain 0.0012 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.1136 0.1207
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0684 0.0738
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0014 0.0108 0.0097
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.634 0.6835
Leishmania major elongation factor-1 gamma 0.0014 0.0108 0.0805
Brugia malayi glycyl-tRNA synthetase 0.0206 0.7113 0.7665
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Echinococcus multilocularis glycyl tRNA synthetase 0.0206 0.7113 0.7669
Loa Loa (eye worm) MBCTL1 0.0053 0.1543 0.1647
Trichomonas vaginalis tubulin beta chain, putative 0.003 0.0684 0.5958
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0265 0.9275 1
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Echinococcus granulosus tubulin alpha chain 0.0012 0.0018 0.002
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0206 0.7113 0.7665
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0499 0.43
Loa Loa (eye worm) beta-tubulin 0.003 0.0684 0.0719
Chlamydia trachomatis methionine--tRNA ligase 0.0265 0.9275 1
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1543 0.1664
Toxoplasma gondii beta-tubulin, putative 0.003 0.0684 0.5958
Echinococcus granulosus tubulin beta 1 chain 0.003 0.0684 0.0738
Echinococcus granulosus tubulin epsilon chain 0.0012 0.0018 0.002
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1306 0.1306
Schistosoma mansoni methionine-tRNA synthetase 0.0042 0.1136 0.1136
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1543 0.1664
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Echinococcus multilocularis tubulin subunit TubB 0.0012 0.0018 0.002
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Echinococcus multilocularis hypothetical protein 0.0012 0.0018 0.002
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0.0684 0.5958
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.1306 0.1408
Schistosoma mansoni tubulin subunit epsilon 0.0012 0.0018 0.0018
Schistosoma mansoni tubulin subunit alpha 0.0012 0.0018 0.0018
Giardia lamblia Beta tubulin 0.003 0.0684 0.5958
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1306 0.1306
Loa Loa (eye worm) hypothetical protein 0.0014 0.0108 0.0097
Leishmania major methionyl-tRNA synthetase, putative 0.0042 0.1136 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0499 0.43
Schistosoma mansoni tubulin subunit gamma 0.0012 0.0018 0.0018
Toxoplasma gondii beta tubulin 0.003 0.0684 0.5958
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0042 0.1136 1
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0684 0.0738
Leishmania major beta tubulin 0.003 0.0684 0.5958
Trypanosoma brucei beta tubulin 0.003 0.0684 0.5958
Leishmania major leucyl-tRNA synthetase, putative 0.0042 0.1136 1
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Echinococcus multilocularis beta tubulin 0.003 0.0684 0.0738
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1543 0.1664
Echinococcus granulosus stringent starvation protein A 0.0014 0.0108 0.0117
Echinococcus multilocularis tubulin alpha 3 chain 0.0012 0.0018 0.002
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0042 0.1136 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1543 0.1543
Schistosoma mansoni alpha tubulin 0.0012 0.0018 0.0018
Echinococcus granulosus tubulin alpha 3 chain 0.0012 0.0018 0.002
Echinococcus multilocularis tubulin alpha chain 0.0012 0.0018 0.002
Echinococcus multilocularis glutathione S transferase 0.0014 0.0108 0.0117
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Loa Loa (eye worm) hypothetical protein 0.0047 0.1306 0.1391
Brugia malayi protein ZK524.3 0.0042 0.1136 0.1207
Brugia malayi beta-tubulin, identical 0.003 0.0684 0.0719
Plasmodium falciparum methionine--tRNA ligase, putative 0.0042 0.1136 1
Loa Loa (eye worm) tubulin beta-2A chain 0.003 0.0684 0.0719
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.1306 0.1408
Echinococcus granulosus methionine tRNA synthetase 0.0042 0.1136 0.1225
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus tubulin alpha 1C chain 0.0012 0.0018 0.002
Trypanosoma brucei elongation factor 1 gamma, putative 0.0014 0.0108 0.0805
Echinococcus granulosus peroxisome assembly protein 26 0.0012 0.0018 0.002
Plasmodium falciparum methionine--tRNA ligase 0.0042 0.1136 1
Loa Loa (eye worm) tubulin beta-1 chain 0.003 0.0684 0.0719
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.1136 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0206 0.7113 0.7665
Leishmania major beta tubulin 0.003 0.0684 0.5958
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Echinococcus granulosus tubulin alpha chain 0.0012 0.0018 0.002
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0206 0.7113 0.7665
Plasmodium vivax tubulin beta chain, putative 0.003 0.0684 0.5958
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0042 0.1136 0.1207
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.1306 0.1408
Brugia malayi methionyl-tRNA synthetase 0.0042 0.1136 0.1207
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0042 0.1136 0.5
Toxoplasma gondii elongation factor 1-gamma, putative 0.0014 0.0108 0.0805
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0042 0.1136 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0499 0.43
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0014 0.0108 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0499 0.43
Trypanosoma brucei beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis tubulin alpha chain 0.0012 0.0018 0.002
Leishmania major hypothetical protein, conserved 0.0025 0.0499 0.43
Schistosoma mansoni glycyl-tRNA synthetase 0.0206 0.7113 0.7113
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0014 0.0108 0.0117
Brugia malayi mbt repeat family protein 0.0047 0.1306 0.1391
Brugia malayi methionyl-tRNA synthetase 0.0265 0.9275 1
Leishmania major beta tubulin 0.003 0.0684 0.5958
Toxoplasma gondii beta-1 tubulin, putative 0.003 0.0684 0.5958
Echinococcus granulosus Tubulin alpha 1 chain 0.0012 0.0018 0.002
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0042 0.1136 0.5
Echinococcus multilocularis Tubulin alpha 1 chain 0.0012 0.0018 0.002
Schistosoma mansoni tubulin subunit alpha 0.0012 0.0018 0.0018
Leishmania major beta tubulin 0.003 0.0684 0.5958
Trypanosoma cruzi beta tubulin, putative 0.003 0.0684 0.5958
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus Tubulin alpha 1 chain 0.0012 0.0018 0.002
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0042 0.1136 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.1306 1
Schistosoma mansoni alpha tubulin 0.0012 0.0018 0.0018
Echinococcus granulosus beta tubulin 0.003 0.0684 0.0738
Schistosoma mansoni tubulin subunit alpha 0.0012 0.0018 0.0018
Leishmania major beta tubulin 0.003 0.0684 0.5958
Treponema pallidum methionyl-tRNA synthetase 0.0265 0.9275 1
Echinococcus multilocularis tubulin alpha chain 0.0012 0.0018 0.002
Trichomonas vaginalis tubulin, putative 0.003 0.0684 0.5958
Loa Loa (eye worm) tubulin beta-4 chain 0.003 0.0684 0.0719
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0.0684 0.5958
Echinococcus granulosus beta tubulin 0.003 0.0684 0.0738
Loa Loa (eye worm) tubulin beta chain 0.003 0.0684 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.1136 0.1207
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Brugia malayi hypothetical protein 0.0025 0.0499 0.0519
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis tubulin alpha 1C chain 0.0012 0.0018 0.002
Echinococcus multilocularis leucyl tRNA synthetase 0.0042 0.1136 0.1225
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0014 0.0108 0.0097
Giardia lamblia Beta tubulin 0.003 0.0684 0.5958
Leishmania major beta tubulin 0.003 0.0684 0.5958
Entamoeba histolytica tubulin family protein 0.003 0.0684 0.0719
Trypanosoma brucei elongation factor 1 gamma, putative 0.0014 0.0108 0.0805
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0042 0.1136 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0012 0.0018 0.002
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0684 0.5958
Echinococcus granulosus tubulin alpha chain 0.0012 0.0018 0.002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.1306 0.1408
Echinococcus multilocularis tubulin alpha chain 0.0012 0.0018 0.002
Echinococcus multilocularis beta tubulin 0.003 0.0684 0.0738
Echinococcus multilocularis tubulin subunit beta 0.003 0.0684 0.0738
Plasmodium vivax elongation factor 1-gamma, putative 0.0014 0.0108 0.0805
Echinococcus granulosus glutathione S transferase 0.0014 0.0108 0.0117
Plasmodium falciparum tubulin beta chain 0.003 0.0684 0.5958
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0684 0.0738
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.1136 1
Schistosoma mansoni methionine-tRNA synthetase 0.0265 0.9275 0.9275
Plasmodium falciparum elongation factor 1-gamma, putative 0.0014 0.0108 0.0805
Giardia lamblia Elongation factor 1-gamma 0.0014 0.0108 0.0805
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0042 0.1136 1
Brugia malayi hypothetical protein 0.0014 0.0108 0.0097
Loa Loa (eye worm) BEN-1 protein 0.003 0.0684 0.0719
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0265 0.9275 1
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus granulosus alpha tubulin 0.0012 0.0018 0.002
Echinococcus granulosus tubulin beta 4A class IVa 0.003 0.0684 0.0738
Giardia lamblia Leucyl-tRNA synthetase 0.0042 0.1136 1
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus multilocularis tubulin alpha 1C chain 0.0012 0.0018 0.002
Giardia lamblia Beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0684 0.0738
Toxoplasma gondii methionyl-tRNA synthetase 0.0042 0.1136 1
Echinococcus granulosus tubulin subunit TubB 0.0012 0.0018 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0108 0.0805
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1543 0.1664
Leishmania major beta tubulin 0.003 0.0684 0.5958
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0265 0.9275 1
Toxoplasma gondii tRNA ligases class I (M) protein 0.0042 0.1136 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.1306 0.1391
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus multilocularis tubulin epsilon chain 0.0012 0.0018 0.002
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1543 0.1647
Loa Loa (eye worm) hypothetical protein 0.0053 0.1543 0.1647
Echinococcus multilocularis tubulin beta 1 chain 0.003 0.0684 0.0738
Echinococcus granulosus tubulin alpha 3 chain 0.0012 0.0018 0.002
Echinococcus multilocularis tubulin, beta 4A class IVa 0.003 0.0684 0.0738
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0042 0.1136 1
Leishmania major elongation factor 1-gamma, putative 0.0014 0.0108 0.0805
Echinococcus granulosus tubulin subunit beta 0.003 0.0684 0.0738
Loa Loa (eye worm) hypothetical protein 0.0025 0.0499 0.0519
Echinococcus granulosus tubulin alpha 0.0012 0.0018 0.002
Trypanosoma brucei beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis tubulin gamma 1 chain 0.0012 0.0018 0.002
Trypanosoma brucei beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus Tubulin alpha 1 chain 0.0012 0.0018 0.002
Schistosoma mansoni leucyl-tRNA synthetase 0.0042 0.1136 0.1136
Leishmania major beta tubulin 0.003 0.0684 0.5958
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0499 0.43
Echinococcus multilocularis Tubulin alpha 1 chain 0.0012 0.0018 0.002
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.1306 0.1306
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0499 0.43
Schistosoma mansoni tubulin subunit beta 0.003 0.0684 0.0684
Onchocerca volvulus 0.0047 0.1306 1
Brugia malayi mbt repeat family protein 0.0047 0.1306 0.1391
Entamoeba histolytica tubulin family protein 0.003 0.0684 0.0719
Echinococcus multilocularis tubulin alpha 0.0012 0.0018 0.002
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Echinococcus granulosus glycyl tRNA synthetase 0.0206 0.7113 0.7669
Leishmania major beta tubulin 0.003 0.0684 0.5958
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus multilocularis tubulin alpha 3 chain 0.0012 0.0018 0.002
Leishmania major beta tubulin 0.003 0.0684 0.5958
Leishmania major beta tubulin 0.003 0.0684 0.5958
Echinococcus granulosus tubulin alpha 1C chain 0.0012 0.0018 0.002
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0223 0.7733 0.8335
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0014 0.0108 0.0805
Loa Loa (eye worm) BEN-1 protein 0.003 0.0684 0.0719
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0684 0.5958
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.0684 0.0738
Echinococcus granulosus tubulin gamma 1 chain 0.0012 0.0018 0.002
Echinococcus multilocularis methionine tRNA synthetase 0.0042 0.1136 0.1225
Giardia lamblia Methionyl-tRNA synthetase 0.0042 0.1136 1
Brugia malayi hypothetical protein 0.0016 0.0178 0.0173
Echinococcus granulosus tubulin alpha chain 0.0012 0.0018 0.002

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -8.791 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.664 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.594 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.441 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.431 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.325 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.868 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.577 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.535 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.143 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 30 nM In vitro cytotoxicity against L1210 (murine leukemia) cells. ChEMBL. 2299625
IC50 (functional) = 30 nM In vitro cytotoxicity against L1210 (murine leukemia) cells. ChEMBL. 2299625
IC50 (functional) = 1.4 uM Inhibitory effect on the polymerization of purified bovine brain tubulin. ChEMBL. 2299625
IC50 (functional) = 1.4 uM Inhibitory effect on the polymerization of purified bovine brain tubulin. ChEMBL. 2299625

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 2299625

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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