Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | acyltransferase | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.8064 | 0.7937 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.9112 | 0.9053 |
Brugia malayi | hypothetical protein | 0.0027 | 0.062 | 0.062 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0169 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.8064 | 0.8064 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0156 | 0.9112 | 0.541 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0169 | 1 | 0.5 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0169 | 1 | 1 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.9112 | 0.9053 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.9112 | 0.541 |
Echinococcus multilocularis | homeobox | 0.0162 | 0.9543 | 0.7638 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0169 | 1 | 0.5 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.8064 | 0.7937 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0169 | 1 | 0.5 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0169 | 1 | 1 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.8064 | 0.7937 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Schistosoma mansoni | transcription factor | 0.0162 | 0.9543 | 0.7638 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.9543 | 0.9513 |
Echinococcus granulosus | Msx-like | 0.0162 | 0.9543 | 0.7638 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0169 | 1 | 1 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0169 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.9112 | 0.541 |
Brugia malayi | RNA binding protein | 0.014 | 0.8064 | 0.8064 |
Brugia malayi | TAR-binding protein | 0.014 | 0.8064 | 0.8064 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.9112 | 0.541 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 355 nM | In vitro inhibitory concentration against radioligand [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 355 nM | In vitro inhibitory concentration against radioligand [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 886 nM | In vitro inhibitory concentration against radioligand [3H]-prazosin binding to alpha-1 adrenergic receptor in rat cortical membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 886 nM | In vitro inhibitory concentration against radioligand [3H]-prazosin binding to alpha-1 adrenergic receptor in rat cortical membrane. | ChEMBL. | 9046348 |
Selectivity (binding) | = 2.5 | Selectivity for alpha1-adrenergic receptor to that of 5-HT1A receptor. | ChEMBL. | 9046348 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.