Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0448 | 0.3057 | 0.3049 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0119 | 0.0238 | 0.0227 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0448 | 0.3057 | 0.3049 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1259 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0102 | 0.0098 | 0.0087 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0448 | 0.3057 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0448 | 0.3057 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0102 | 0.0098 | 0.0087 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0119 | 0.0238 | 0.0745 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0448 | 0.3057 | 0.3049 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3057 | 0.3057 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0448 | 0.3057 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0119 | 0.0238 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1259 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Onchocerca volvulus | 0.1259 | 1 | 1 | |
Echinococcus multilocularis | fk506 binding protein | 0.0119 | 0.0238 | 0.0227 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0119 | 0.0238 | 0.0227 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1259 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1259 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0448 | 0.3057 | 0.3049 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0448 | 0.3057 | 0.3049 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0448 | 0.3057 | 0.3049 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0448 | 0.3057 | 0.3049 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1259 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0448 | 0.3057 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.1259 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0119 | 0.0238 | 0.0227 |
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.1259 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0119 | 0.0238 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0119 | 0.0238 | 0.0238 |
Chlamydia trachomatis | SWIB complex protein | 0.1259 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0119 | 0.0238 | 0.0227 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0448 | 0.3057 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0448 | 0.3057 | 0.3049 |
Loa Loa (eye worm) | brahma associated protein | 0.1259 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0102 | 0.0098 | 0.0087 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0448 | 0.3057 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0011 | 0.0011 |
Leishmania major | fk506-binding protein 1-like protein | 0.0119 | 0.0238 | 0.0745 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1259 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0119 | 0.0238 | 0.0227 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0448 | 0.3057 | 0.3049 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0448 | 0.3057 | 0.3049 |
Schistosoma mansoni | hypothetical protein | 0.1259 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0448 | 0.3057 | 0.3049 |
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0119 | 0.0238 | 0.0227 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0119 | 0.0238 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0448 | 0.3057 | 0.3049 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0119 | 0.0238 | 0.0227 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0448 | 0.3057 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1259 | 1 | 1 |
Schistosoma mansoni | fusion | 0.0448 | 0.3057 | 0.3049 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1259 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0119 | 0.0238 | 0.0227 |
Plasmodium vivax | hypothetical protein, conserved | 0.1259 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0448 | 0.3057 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0448 | 0.3057 | 0.3049 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1259 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1259 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1259 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0119 | 0.0238 | 0.0745 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0119 | 0.0238 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0119 | 0.0238 | 0.0227 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1259 | 1 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0448 | 0.3057 | 0.3049 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0448 | 0.3057 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0119 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3057 | 0.3057 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0448 | 0.3057 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0448 | 0.3057 | 1 |
Toxoplasma gondii | ran binding protein | 0.0448 | 0.3057 | 0.3049 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1259 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0119 | 0.0238 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0448 | 0.3057 | 0.3049 |
Schistosoma mansoni | hypothetical protein | 0.0448 | 0.3057 | 0.3049 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0119 | 0.0238 | 0.0227 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1259 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0119 | 0.0238 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1259 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1259 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0448 | 0.3057 | 0.3049 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0448 | 0.3057 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3057 | 0.3057 |
Schistosoma mansoni | hypothetical protein | 0.1259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0098 | 0.0098 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TCID50 (functional) | = 18.1 uM | Dose required to inhibit the growth of mouse hepatitis virus (MHV) in infected mouse astrocytoma (DBT) cells using plaque assay | ChEMBL. | 2153821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.