TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.333 | Formula: C18H16F3N3O3
H donors: 2 H acceptors: 3 LogP: 3.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1c[nH]c2=C(CCC(n2c1=O)C)/C=N/c1ccc(cc1)C(F)(F)F
InChi: 1S/C18H16F3N3O3/c1-10-2-3-11(15-23-9-14(17(26)27)16(25)24(10)15)8-22-13-6-4-12(5-7-13)18(19,20)21/h4-10,23H,2-3H2,1H3,(H,26,27)/b22-8+
InChiKey: BMVDCEBYLUAMQR-GZIVZEMBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0334	0.1727	0.3287
Echinococcus multilocularis	voltage dependent calcium channel	0.0075	0.0268	0.2814
Echinococcus multilocularis	zinc phosphodiesterase	0.0034	0.0033	0.0295
Brugia malayi	jmjC domain containing protein	0.0063	0.02	0.0784
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0034	0.0033	0.0295
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.1131	0.213
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0268	0.1064
Onchocerca volvulus		0.0036	0.0044	0.0155
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0181	0.0863	0.1444
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0034	0.0033	0.0295
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0044	0.0413
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0007	0.0012
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0101	0.0414	0.1648
Onchocerca volvulus		0.0034	0.0033	0.0111
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.02	0.2091
Chlamydia trachomatis	transglycolase/transpeptidase	0.0878	0.4792	0.5094
Treponema pallidum	penicillin-binding protein (pbp-2)	0.1052	0.5777	0.5762
Brugia malayi	hypothetical protein	0.0138	0.0621	0.2481
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0045	0.0099	0.0996
Schistosoma mansoni	lamin	0.0029	0.0007	0.0008
Echinococcus granulosus	lamin dm0	0.0029	0.0007	0.0072
Toxoplasma gondii	ABC1 family protein	0.0036	0.0044	0.0413
Echinococcus granulosus	ETHE1 protein	0.0034	0.0033	0.0357
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0044	0.0019
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0118	0.0509	0.5444
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0044	0.0012
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0044	0.0021
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0045	0.0099	0.1054
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0051	0.0487
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0045	0.0099	0.0374
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0006	0.0064
Loa Loa (eye worm)	runx1	0.0059	0.0174	0.0687
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0045	0.0099	0.0114
Schistosoma mansoni	hypothetical protein	0.0034	0.0033	0.0295
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0051	0.0192
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0034	0.0033	0.0357
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0051	0.0198
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0075	0.0268	0.2814
Trichomonas vaginalis	set domain proteins, putative	0.023	0.1138	0.1923
Echinococcus granulosus	transcription factor btf3	0.0037	0.0051	0.0548
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0057	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0045	0.0099	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0051	0.0031
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0101	0.0414	0.4223
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0194	0.0935	1
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0045	0.0099	0.0385
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0911	0.4978	0.5526
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0044	0.0019
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0044	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0118	0.0509	0.5415
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0034	0.0033	0.0295
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0034	0.0033	0.012
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Brugia malayi	ethe1-prov protein	0.0034	0.0033	0.0111
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0044	0.0155
Trypanosoma brucei	beta lactamase	0.0334	0.1727	1
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0045	0.0099	0.0127
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0044	0.0164
Loa Loa (eye worm)	hypothetical protein	0.036	0.187	0.7526
Brugia malayi	hypothetical protein	0.0468	0.2484	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0044	0.0413
Leishmania major	xanthine phosphoribosyltransferase	0.0194	0.0935	1
Loa Loa (eye worm)	calcium channel	0.0075	0.0268	0.1064
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0148	0.068	0.1125
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0075	0.0268	0.2814
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0385
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0075	0.0268	0.2814
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0045	0.0099	0.0127
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0063	0.02	0.2141
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	0.5326
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0034	0.0033	0.0295
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0057	0.0552
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0948	0.5186	0.5758
Schistosoma mansoni	transcription factor btf3	0.0037	0.0051	0.0487
Chlamydia trachomatis	transglycolase/transpeptidase	0.1691	0.9376	1
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0194	0.0935	1
Mycobacterium tuberculosis	Conserved protein	0.0045	0.0099	0.0127
Echinococcus multilocularis	sodium channel protein	0.0032	0.0023	0.0182
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0044	0.0019
Brugia malayi	Adenine phosphoribosyltransferase	0.0045	0.0099	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0006	0.0009
Brugia malayi	Pre-SET motif family protein	0.0202	0.0981	0.3934
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0045	0.0099	0.0127
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.1691	0.9376	1
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0051	0.7467
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0044	0.0019
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	1
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0045	0.0099	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0033	0.012
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0045	0.0099	0.0723
Treponema pallidum	adenine phosphoribosyltransferase	0.0045	0.0099	0.0065
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0034	0.0033	0.0357
Giardia lamblia	Adenine phosphoribosyltransferase	0.0045	0.0099	0.0723
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0044	0.0021
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	0.1571
Onchocerca volvulus		0.0036	0.0044	0.0155
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0044	0.0021
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0034	0.0033	0.012
Echinococcus granulosus	voltage dependent calcium channel	0.0075	0.0268	0.286
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0194	0.0935	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0044	0.0155
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0044	0.0021
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0033	0.0295
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	1
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0051	0.0487
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0044	0.0019
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	1
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.1621	0.8982	1
Schistosoma mansoni	jumonji domain containing protein	0.0063	0.02	0.2091
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0044	0.0413
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Echinococcus multilocularis	voltage dependent calcium channel	0.0075	0.0268	0.2814
Entamoeba histolytica	hypothetical protein	0.0038	0.0057	1
Mycobacterium leprae	Probable penicillin-binding membrane protein PbpB	0.0452	0.239	0.4103
Treponema pallidum	penicillin-binding protein (pbp-1)	0.1691	0.9376	0.9373
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0194	0.0935	0.1008
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0045	0.0099	0.0996
Schistosoma mansoni	lamin	0.0029	0.0007	0.0008
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0032	0.0023	0.0246
Trichomonas vaginalis	esterase, putative	0.0036	0.0044	0.0019
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0045	0.0099	0.0073
Brugia malayi	hypothetical protein	0.0038	0.0057	0.0207
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0045	0.0099	0.0996
Giardia lamblia	Guanine phosphoribosyltransferase	0.0194	0.0935	1
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0034	0.0033	0.012
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0045	0.0099	0.0723
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0044	0.0021
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0045	0.0099	0.0127
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0045	0.0099	0.0996
Echinococcus multilocularis	lamin dm0	0.0029	0.0007	0.0008
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0034	0.0033	0.0111
Brugia malayi	beta-NAC-like protein	0.0037	0.0051	0.0183
Entamoeba histolytica	hypothetical protein	0.0038	0.0057	1
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0696	0.3769	0.4174
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0034	0.0033	0.0111
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0034	0.0033	0.0295
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0051	0.0198
Schistosoma mansoni	zinc phosphodiesterase	0.0034	0.0033	0.0295
Echinococcus multilocularis	lamin	0.0029	0.0007	0.0008
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0045	0.0099	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0033	0.012
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0057	0.0612
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0075	0.0268	0.2814
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0046	0.0101	0.0751
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0051	0.0198
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0051	0.0198
Brugia malayi	beta-lactamase	0.0036	0.0044	0.0155
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0045	0.0099	0.0996
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0194	0.0935	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0044	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0033	0.012
Onchocerca volvulus		0.023	0.1138	0.4569
Echinococcus multilocularis	musashi	0.0029	0.0007	0.0008
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0044	0.0012
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0911	0.4978	0.861
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0034	0.0033	0.0295
Mycobacterium tuberculosis	Probable penicillin-binding membrane protein PbpB	0.0452	0.239	0.4573
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0044	0.0065
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0063	0.02	0.2091
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0075	0.0268	0.286
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0045	0.0099	0.0374
Leishmania major	adenine phosphoribosyltransferase	0.0045	0.0099	0.0723
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	0.5326
Leishmania major	hypothetical protein, conserved	0.0036	0.0044	0.0122
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.0981	0.394
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0075	0.0268	0.2814
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0181	0.0863	0.0927
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0007	0.0008
Mycobacterium tuberculosis	Conserved protein	0.0045	0.0099	0.0127
Onchocerca volvulus		0.0036	0.0044	0.0155
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0911	0.4978	0.9598
Mycobacterium ulcerans	lipoprotein LpqF	0.0334	0.1727	0.1893
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0118	0.0509	0.2039
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0468	0.2484	1
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0051	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.1052	0.5777	1
Echinococcus granulosus	lamin	0.0029	0.0007	0.0072
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.02	0.0793
Onchocerca volvulus		0.0194	0.0935	0.3751
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0007	0.0012
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0044	0.0021
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0044	0.0012
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0075	0.0268	0.286
Echinococcus granulosus	intermediate filament protein	0.0029	0.0007	0.0072
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0044	0.0122
Onchocerca volvulus		0.0029	0.0007	0.0003
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0044	0.0475
Schistosoma mansoni	zinc phosphodiesterase	0.0034	0.0033	0.0295
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0045	0.0099	0.0996
Mycobacterium ulcerans	lipase LipD	0.0036	0.0044	0.0012
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0044	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0051	0.0031
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0045	0.0099	0.007
Mycobacterium ulcerans	hypothetical protein	0.0045	0.0099	0.0073
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0045	0.0099	0.0996
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0194	0.0935	0.3751
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0051	0.0031
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0046	0.0101	0.04
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0044	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0468	0.2484	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0007	0.0012
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0334	0.1727	0.2949
Mycobacterium tuberculosis	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase	0.0322	0.1659	0.3155
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.02	0.2091
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0075	0.0268	0.1056
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0044	0.0021
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0044	0.0164
Onchocerca volvulus	Putative hydrolase PNKD	0.0034	0.0033	0.0111
Brugia malayi	jmjC domain containing protein	0.0063	0.02	0.0784
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0034	0.0033	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0044	0.0122
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0045	0.0099	0.0114
Onchocerca volvulus		0.0034	0.0033	0.0111
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0034	0.0033	0.0295
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0045	0.0099	0.0996
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0044	0.0019
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0385
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0696	0.3769	0.725
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0045	0.0099	0.0996
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0194	0.0935	0.5326
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0044	0.0021
Schistosoma mansoni	voltage-gated cation channel	0.0075	0.0268	0.2814
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0045	0.0099	0.007
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0426	0.2245	0.3852
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0426	0.2245	0.4293
Echinococcus multilocularis	lysine specific demethylase 5A	0.0063	0.02	0.2091
Onchocerca volvulus		0.0029	0.0007	0.0003
Onchocerca volvulus		0.0468	0.2484	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0075	0.0268	0.2814
Plasmodium vivax	unspecified product	0.0034	0.0033	0.0295
Echinococcus granulosus	zinc phosphodiesterase	0.0034	0.0033	0.0357
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.1052	0.5777	0.6418
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0075	0.0268	0.286
Echinococcus multilocularis	Protein lozenge	0.0059	0.0174	0.1808
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0044	0.0012
Entamoeba histolytica	hypothetical protein	0.0038	0.0057	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0007	0.0003
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0034	0.0033	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0033	0.012
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0045	0.0099	0.0383
Treponema pallidum	hypothetical protein	0.0181	0.0861	0.083
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0045	0.0099	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0164
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0045	0.0099	0.0114
Echinococcus multilocularis	ETHE1 protein	0.0034	0.0033	0.0295
Schistosoma mansoni	hypothetical protein	0.0034	0.0033	0.0295
Brugia malayi	intermediate filament protein	0.0029	0.0007	0.0003
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0194	0.0935	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0045	0.0099	0.0127
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0118	0.0509	0.5415
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0426	0.2245	0.2472
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0044	0.0021
Schistosoma mansoni	lozenge	0.0059	0.0174	0.1808
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0045	0.0099	0.0073
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0034	0.0033	0.0111
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0948	0.5186	1
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0045	0.0099	0.0383
Entamoeba histolytica	hypothetical protein	0.0037	0.0051	0.7467
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0057	0.0552
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0045	0.0099	0.0723
Echinococcus granulosus	lysine specific demethylase 5A	0.0063	0.02	0.2141
Giardia lamblia	Kinase, AGC AKT	0.0101	0.0414	0.4223
Treponema pallidum	hypothetical protein	0.0045	0.0099	0.0065
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0948	0.5186	0.8971
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0194	0.0935	1
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0148	0.068	0.1254
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0045	0.0099	0.0114
Schistosoma mansoni	hypothetical protein	0.0038	0.0057	0.0552
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0045	0.0099	0.1054
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.1052	0.5777	1
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0051	0.0487
Brugia malayi	hypothetical protein	0.0034	0.0033	0.0111
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0181	0.0863	0.1609

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	> 100 uM kg-1	Antiallergic activity by passive cutaneous anaphylaxis test after intravenous administration.	ChEMBL.	6148420

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 27190