Detailed information for compound 272431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.93 | Formula: C25H25ClN2O4
  • H donors: 2 H acceptors: 2 LogP: 5.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/NC(=O)c2ccc(c(c2)Cl)O)ccc1OCc1ccc(cc1)C(C)C
  • InChi: 1S/C25H25ClN2O4/c1-16(2)19-7-4-17(5-8-19)15-32-23-11-6-18(12-24(23)31-3)14-27-28-25(30)20-9-10-22(29)21(26)13-20/h4-14,16,29H,15H2,1-3H3,(H,28,30)/b27-14+
  • InChiKey: POMDFIAGRWBFAV-MZJWZYIUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon receptor 477 aa 457 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0911 1 1
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.2061 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Echinococcus granulosus nuclear receptor nhr 48 0.043 0.4671 0.4671
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.043 0.4671 0.4661
Echinococcus multilocularis cpg binding protein 0.0029 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0911 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0911 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0911 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0911 1 1
Echinococcus granulosus transcription factor btf3 0.0034 0.0286 0.0286
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1513 0.1513
Echinococcus granulosus Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0911 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0911 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0911 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.043 0.4671 0.4661
Schistosoma mansoni hypothetical protein 0.0164 0.1728 0.1728
Echinococcus multilocularis geminin 0.0164 0.1728 0.1728
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0292 0.0292
Schistosoma mansoni thyroid hormone receptor 0.0911 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.043 0.4671 0.4671
Echinococcus granulosus Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0494 0.5389 0.5
Schistosoma mansoni hypothetical protein 0.0396 0.4295 0.4295
Echinococcus granulosus neuropeptide s receptor 0.0447 0.4867 0.4867
Echinococcus multilocularis glutamine synthetase 0.0769 0.8428 0.8428
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0481 0.5241 0.5232
Loa Loa (eye worm) DR-78 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni retinoic acid receptor RXR 0.0911 1 1
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0194 0.2061 0.8175
Loa Loa (eye worm) nuclear hormone receptor 0.043 0.4671 0.4661
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.022 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0238 0.022
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.4867 0.4867
Brugia malayi nuclear receptor NHR-88 0.043 0.4671 0.4661
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.2061 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0292 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor 0.0911 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.022 0.022
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0292 0.0275
Schistosoma mansoni cpg binding protein 0.0029 0.0237 0.0237
Brugia malayi hypothetical protein 0.043 0.4671 0.4661
Brugia malayi photoreceptor-specific nuclear receptor 0.0911 1 1
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0194 0.2061 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0911 1 1
Brugia malayi Nuclear hormone receptor E75 0.043 0.4671 0.4661
Schistosoma mansoni nuclear hormone receptor 0.043 0.4671 0.4671
Schistosoma mansoni cpg binding protein 0.0029 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0292 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0238 0.0238
Loa Loa (eye worm) nuclear receptor nhr-7B 0.043 0.4671 0.4661
Onchocerca volvulus 0.043 0.4671 0.4551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor 0.043 0.4671 0.4671
Brugia malayi conserved hypotetical protein 0.043 0.4671 0.4661
Brugia malayi tailless protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0292 0.0274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4295 0.4295
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0911 1 1
Echinococcus granulosus muscleblind protein 0.0145 0.1513 0.1513
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.043 0.4671 0.4671
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Schistosoma mansoni zinc finger protein 0.043 0.4671 0.4671
Onchocerca volvulus 0.0911 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0911 1 1
Brugia malayi hypothetical protein 0.0481 0.5241 0.5233
Plasmodium vivax glutamine synthetase, putative 0.0494 0.5389 1
Echinococcus multilocularis muscleblind protein 0.0145 0.1513 0.1513
Brugia malayi hypothetical protein 0.0481 0.5241 0.5233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0911 1 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0081 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0911 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0911 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0911 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.043 0.4671 0.4671
Echinococcus multilocularis GPCR, family 2 0.0034 0.0292 0.0292
Loa Loa (eye worm) Gln-2 protein 0.0494 0.5389 0.538
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0911 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0911 1 1
Schistosoma mansoni transcription factor btf3 0.0034 0.0286 0.0286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0481 0.5241 0.5241
Echinococcus granulosus GPCR family 2 0.0034 0.0292 0.0292
Echinococcus multilocularis transcription factor btf3 0.0034 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0164 0.1728 0.1728
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0911 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.4867 0.4867
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.043 0.4671 0.4671
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0911 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0911 1 1
Schistosoma mansoni coup transcription factor 0.0911 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.043 0.4671 0.4671
Onchocerca volvulus 0.0029 0.0238 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0911 1 1
Trypanosoma brucei glutamine synthetase, putative 0.0769 0.8428 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0494 0.5389 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0507 0.0802
Echinococcus granulosus ecdysone induced protein 78C 0.0911 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0911 1 1
Schistosoma mansoni nuclear receptor 0.043 0.4671 0.4671
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0074 0.0733 0.0733
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0286 0.0246
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0238 0.0238
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.043 0.4671 0.4551
Schistosoma mansoni cpg binding protein 0.0028 0.022 0.022
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0286 0.0246
Brugia malayi Nuclear hormone receptor-like 1 0.0481 0.5241 0.5233
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.043 0.4671 0.4671
Leishmania major basic transcription factor 3a, putative 0.0034 0.0286 0.0246
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0911 1 1
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.2061 0.2061
Schistosoma mansoni nuclear receptor 0.043 0.4671 0.4671
Brugia malayi Pre-SET motif family protein 0.0029 0.0238 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0286 0.0387
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Onchocerca volvulus Glutamine synthetase homolog 0.0494 0.5389 0.5286
Brugia malayi nuclear receptor RXR 0.043 0.4671 0.4661
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0286 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0911 1 1
Brugia malayi nuclear receptor RXR 0.0481 0.5241 0.5233
Loa Loa (eye worm) steroid hormone receptor 0.0911 1 1
Brugia malayi Pre-SET motif family protein 0.0202 0.2149 0.2135
Schistosoma mansoni RAR-like nuclear receptor 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.043 0.4671 0.4671
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0911 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0911 1 1
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.2061 0.2061
Brugia malayi Nuclear hormone receptor-like 1 0.0481 0.5241 0.5233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1113 0.1097
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4295 0.4295
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0911 1 1
Echinococcus granulosus cpg binding protein 0.0029 0.0237 0.0237
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.4867 0.4867
Loa Loa (eye worm) nuclear receptor NHR-67 0.043 0.4671 0.4661
Brugia malayi ecdysone receptor 0.043 0.4671 0.4661
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0911 1 1
Brugia malayi hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Toxoplasma gondii glutamine synthetase, type I, putative 0.0494 0.5389 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.043 0.4671 0.4671
Brugia malayi nuclear receptor NHR-88 0.0911 1 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0286 0.0387
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1113 0.1096
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0733 0.0715
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0911 1 1
Echinococcus granulosus geminin 0.0164 0.1728 0.1728
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0494 0.5389 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0911 1 1
Mycobacterium ulcerans glutamine synthetase 0.0494 0.5389 1
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0238 0.0238
Brugia malayi nuclear hormone receptor 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0108 0.1113 0.1096
Brugia malayi Nuclear hormone receptor E75 0.043 0.4671 0.4661
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0274
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0238 0.0296
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0081 0.0062
Brugia malayi nuclear hormone receptor 0.0911 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0145 0.1513 0.1497
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0733 0.0717
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0911 1 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0286 0.0387
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0292 0.0292
Onchocerca volvulus 0.023 0.2457 0.2288
Echinococcus granulosus thyroid hormone receptor alpha 0.043 0.4671 0.4671
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0481 0.5241 0.5241
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8428 1
Brugia malayi beta-NAC-like protein 0.0034 0.0286 0.0269
Brugia malayi steroid hormone receptor 0.0911 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.043 0.4671 0.4661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0911 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0911 1 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0194 0.2061 0.373
Trichomonas vaginalis glutamine synthetase, putative 0.0194 0.2061 0.8175
Echinococcus multilocularis nuclear receptor nhr 48 0.043 0.4671 0.4671
Onchocerca volvulus 0.043 0.4671 0.4551
Trichomonas vaginalis set domain proteins, putative 0.023 0.2457 1
Echinococcus multilocularis FTZ F1 alpha 0.0911 1 1
Echinococcus granulosus glutamine synthetase 0.0769 0.8428 0.8428
Brugia malayi glutamine synthetase 0.0274 0.2951 0.2938
Brugia malayi nuclear hormone receptor family member nhr-6 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Brugia malayi isocitrate dehydrogenase 0.0015 0.0081 0.0064
Plasmodium vivax SET domain protein, putative 0.0029 0.0238 0.0296
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.8602 0.8602
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Brugia malayi nuclear receptor NHR-67 0.043 0.4671 0.4661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0911 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2149 0.2134
Loa Loa (eye worm) hypothetical protein 0.0145 0.1513 0.1497
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0576 0.0576
Echinococcus multilocularis ecdysone induced protein 78C 0.0911 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.043 0.4671 0.4551
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1113 0.1097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0911 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Echinococcus multilocularis Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0911 1 1
Schistosoma mansoni thyroid hormone receptor 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0286 0.0268
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0911 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0481 0.5241 0.5241
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8428 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.022 0.0202
Brugia malayi Muscleblind-like protein 0.0145 0.1513 0.1498
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0769 0.8428 0.8428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0911 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0911 1 1
Plasmodium falciparum glutamine synthetase, putative 0.0494 0.5389 1
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0911 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Leishmania major glutamine synthetase, putative 0.0769 0.8428 1
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0481 0.5241 0.5241

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Displacement of [125I]PACAP27 from PAC1R (unknown origin) expressed in HEK293f cells ChEMBL. 18272364
Activity (binding) 0 Displacement of [125I]PACAP27 from PAC1R (unknown origin) expressed in HEK293f cells ChEMBL. 18272364
IC50 (binding) = 1.3 uM In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon ChEMBL. 11844695
IC50 (binding) = 1.3 uM In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon ChEMBL. 11844695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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