Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0274 | 0.0274 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0028 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Plasmodium vivax | vivapain-2 | 0.0028 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0053 | 0.2688 | 0.2688 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0151 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0151 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0028 | 0.086 | 0.086 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0028 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0028 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0151 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0053 | 0.2688 | 0.2482 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.086 | 0.086 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0151 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0151 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0053 | 0.2688 | 0.2688 |
Onchocerca volvulus | Cathepsin L homolog | 0.0028 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0274 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0053 | 0.2688 | 1 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0053 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0053 | 0.2688 | 1 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0028 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0028 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.002 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Loa Loa (eye worm) | ctsf protein | 0.0028 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0274 | 0.1018 |
Echinococcus granulosus | cathepsin b | 0.0151 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0028 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0274 | 0.1018 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0028 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine protease, putative | 0.0028 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.086 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0028 | 0.086 | 0.0603 |
Brugia malayi | cathepsin L-like precursor | 0.002 | 0.0274 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0028 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0028 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0028 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0028 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0028 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0028 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.2688 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.002 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0028 | 0.086 | 0.086 |
Echinococcus multilocularis | cysteine protease | 0.0028 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cysteine protease | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0151 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.086 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0151 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0028 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0028 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0151 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0028 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.086 | 0.0603 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0028 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0028 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0053 | 0.2688 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0028 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.086 | 0.3201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antifertility potency (functional) | = 0 | Antifertility activity measured as minimum protective dose for prevention of pregnancy in rats | ChEMBL. | 3560158 |
Estrogenic potency (functional) | = 0 | Oral estrogenic activity in 21 day old immature ovariectomized rats at 200 ug | ChEMBL. | 3560158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.