TDR Targets

Basic information

Technical information

TDR Targets ID: 27610
Name: 1-(3-aminophenyl)-7,8-dimethoxy-3-methyl-5H-2 ,3-benzodiazepin-4-one
MW: 325.362 | Formula: C18H19N3O3
H donors: 1 H acceptors: 1 LogP: 2.06 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)CC(=O)N(N=C2c1cccc(c1)N)C
InChi: 1S/C18H19N3O3/c1-21-17(22)9-12-8-15(23-2)16(24-3)10-14(12)18(20-21)11-5-4-6-13(19)7-11/h4-8,10H,9,19H2,1-3H3
InChiKey: ZVYZPIJDNUFDKX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0972	0.0972
Echinococcus granulosus	cathepsin l1	0.0188	0.1786	0.1786
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.015	0.1217	0.1217
Echinococcus multilocularis	cathepsin b	0.0746	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0271	0.3003	0.3003
Echinococcus granulosus	cathepsin b	0.0746	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Trypanosoma cruzi	cysteine proteinase, putative	0.015	0.1217	0.1217
Trypanosoma cruzi	cysteine peptidase, putative	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1786	0.5774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Entamoeba histolytica	cysteine protease, putative	0.0271	0.3003	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0156	0.1303	0.4338
Echinococcus multilocularis	cysteine protease	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine proteinase 1, putative	0.015	0.1217	0.4054
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0156	0.1303	0.5
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0972	0.0972
Plasmodium vivax	unspecified product	0.0083	0.0229	0.0761
Brugia malayi	cathepsin F-like cysteine proteinase	0.0083	0.0229	0.0229
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0156	0.1303	0.1303
Trypanosoma cruzi	cruzipain precursor, putative	0.0083	0.0229	0.0229
Loa Loa (eye worm)	cathepsin B	0.0277	0.3093	0.3093
Schistosoma mansoni	cathepsin s	0.0083	0.0229	0.0229
Schistosoma mansoni	cathepsin F (C01 family)	0.0271	0.3003	0.3003
Onchocerca volvulus	Cathepsin F homolog	0.0271	0.3003	1
Onchocerca volvulus		0.0133	0.0972	0.3236
Plasmodium vivax	unspecified product	0.015	0.1217	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0271	0.3003	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0277	0.3093	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Giardia lamblia	Cathepsin B precursor	0.0277	0.3093	1
Onchocerca volvulus		0.0188	0.1786	0.5946
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0156	0.1303	0.4212
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1217	0.1217
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0156	0.1303	0.1303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0083	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1786	0.1786
Trypanosoma cruzi	cysteine peptidase, putative	0.0083	0.0229	0.0229
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine proteinase 2	0.015	0.1217	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0271	0.3003	0.3003
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0133	0.0965	0.0965
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0271	0.3003	1
Brugia malayi	eukaryotic initiation factor 4A	0.0156	0.1303	0.1303
Plasmodium vivax	vivapain-2	0.0271	0.3003	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0746	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1217	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0271	0.3003	0.3003
Onchocerca volvulus		0.0271	0.3003	1
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0271	0.3003	0.3003
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0156	0.1303	0.4338
Loa Loa (eye worm)	ctsf protein	0.0271	0.3003	0.3003
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine proteinase, putative	0.0271	0.3003	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Treponema pallidum	ATP-dependent RNA helicase	0.0156	0.1303	0.5
Leishmania major	cysteine peptidase A (CPA)	0.0271	0.3003	0.9499
Brugia malayi	Trypsin family protein	0.0133	0.0972	0.0972
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0277	0.3093	1
Toxoplasma gondii	cathepsin B	0.0277	0.3093	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0156	0.1303	0.4212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Trypanosoma cruzi	cysteine protease, putative	0.015	0.1217	0.1217
Echinococcus multilocularis	cathepsin L cysteine protease	0.0271	0.3003	0.3003
Plasmodium vivax	vivapain-2	0.0271	0.3003	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0965	0.0965
Echinococcus granulosus	cathepsin b	0.0746	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0083	0.0229	0.0229
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0746	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1217	0.4054
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0156	0.1303	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1303	0.1303
Loa Loa (eye worm)	fibroinase	0.0271	0.3003	0.3003
Brugia malayi	Papain family cysteine protease containing protein	0.015	0.1217	0.1217
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.015	0.1217	0.1217
Plasmodium vivax	vivapain-3	0.015	0.1217	0.4054
Onchocerca volvulus		0.0271	0.3003	1
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0133	0.0965	0.0965
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Giardia lamblia	Cathepsin B precursor	0.0277	0.3093	1
Onchocerca volvulus		0.0271	0.3003	1
Onchocerca volvulus		0.0271	0.3003	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1786	0.1786
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0229	0.0229
Entamoeba histolytica	cysteine proteinase, putative	0.0271	0.3003	1
Onchocerca volvulus		0.0271	0.3003	1
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0156	0.1303	0.4212
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0271	0.3003	0.3003
Toxoplasma gondii	cathepsin CPL	0.0271	0.3003	0.971
Onchocerca volvulus		0.0271	0.3003	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1786	0.5774
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0271	0.3003	1
Giardia lamblia	Cathepsin B precursor	0.0277	0.3093	1
Brugia malayi	Papain family cysteine protease containing protein	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Echinococcus multilocularis	cathepsin L	0.015	0.1217	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0746	1	1
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Onchocerca volvulus		0.009	0.0337	0.1123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0156	0.1303	0.4212
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0156	0.1303	0.1303
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0746	1	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0156	0.1303	0.0455
Trypanosoma cruzi	cruzipain precursor, putative	0.0271	0.3003	0.3003
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0277	0.3093	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0188	0.1786	0.1786
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0229	0.0229
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1217	0.4054
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Echinococcus multilocularis	cathepsin b	0.0746	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0746	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1217	0.3937
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0277	0.3093	1
Echinococcus multilocularis	cysteine protease	0.0271	0.3003	0.3003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.0972	0.0972
Entamoeba histolytica	cysteine proteinase, putative	0.0188	0.1786	0.5946
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0271	0.3003	0.3003
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0156	0.1303	0.1303
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.015	0.1217	0.1217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Onchocerca volvulus	Cathepsin L homolog	0.0271	0.3003	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Echinococcus granulosus	cathepsin l1	0.0271	0.3003	0.3003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0271	0.3003	0.971
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Trypanosoma cruzi	cysteine proteinase, putative	0.015	0.1217	0.1217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Echinococcus granulosus	cysteine protease	0.015	0.1217	0.1217
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.015	0.1217	0.1217
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0156	0.1303	0.4338
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0156	0.1303	0.1303
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Plasmodium falciparum	cysteine proteinase falcipain 1	0.015	0.1217	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0277	0.3093	0.3093
Schistosoma mansoni	cathepsin F (C01 family)	0.0188	0.1786	0.1786
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Echinococcus granulosus	cathepsin L	0.015	0.1217	0.1217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.0972	0.0972
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1786	0.1786
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0156	0.1303	0.1303
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1786	0.1786
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1217	0.3937
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0156	0.1303	0.1303
Brugia malayi	Cathepsin L-like precursor	0.0271	0.3003	0.3003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Brugia malayi	cathepsin L-like precursor	0.0188	0.1786	0.1786
Plasmodium vivax	vivapain-1	0.015	0.1217	0.4054
Onchocerca volvulus		0.0271	0.3003	1
Echinococcus granulosus	cathepsin L cysteine protease	0.015	0.1217	0.1217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Brugia malayi	Cathepsin L-like precursor	0.0083	0.0229	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0271	0.3003	0.971
Onchocerca volvulus	Cathepsin L homolog	0.0271	0.3003	1
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1786	0.1786
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.3003	0.971
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0746	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1217	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0271	0.3003	0.3003
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0188	0.1786	0.1786
Plasmodium vivax	RNA helicase-1, putative	0.0156	0.1303	0.4338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.3003	0.971
Leishmania major	cathepsin L-like protease	0.0271	0.3003	0.9499
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0156	0.1303	0.4212
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0271	0.3003	0.3003
Trypanosoma cruzi	cysteine peptidase, putative	0.0271	0.3003	0.3003
Entamoeba histolytica	cysteine protease, putative	0.015	0.1217	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0271	0.3003	0.3003
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.015	0.1217	0.1217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522
Loa Loa (eye worm)	cysteine protease	0.0271	0.3003	0.3003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0271	0.3003	0.9522

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 9.94 mg kg-1	Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 9.94 mg kg-1	Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 11.9 mg kg-1	Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 11.9 mg kg-1	Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 30.6 uM	In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice	ChEMBL.	15027880
ED50 (functional)	= 30.6 uM	In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice	ChEMBL.	15027880
ED50 (functional)	= 36.8 uM	In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice	ChEMBL.	15027880
ED50 (functional)	= 36.8 uM	In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice	ChEMBL.	15027880
ED50 (functional)	= 30.6 uM kg-1	Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 30.6 uM kg-1	Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 36.8 uM kg-1	Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
ED50 (functional)	= 36.8 uM kg-1	Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg	ChEMBL.	9111300
Rm	= -0.327	Relative lipophilicity of compound	ChEMBL.	9111300

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL22255
PubChem: 10758416

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 27610