TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 511.634 | Formula: C17H21K3N3O6P
H donors: 3 H acceptors: 6 LogP: 1.54 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCCC[C@@H](C(=O)N[C@H](C(=O)[O-])Cc1c[nH]c2c1cccc2)NP(=O)([O-])[O-].[K+].[K+].[K+]
InChi: 1S/C17H24N3O6P.3K/c1-2-3-7-14(20-27(24,25)26)16(21)19-15(17(22)23)9-11-10-18-13-8-5-4-6-12(11)13;;;/h4-6,8,10,14-15,18H,2-3,7,9H2,1H3,(H,19,21)(H,22,23)(H3,20,24,25,26);;;/q;3*+1/p-3/t14-,15-;;;/m0.../s1
InChiKey: NYVZQOLCRXDUOS-CEHYLXJWSA-K

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Endothelin-converting enzyme 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus granulosus	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Toxoplasma gondii	peptidase family M13 protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium leprae	probable zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	Get druggable targets OG5_127344	All targets in OG5_127344
Neospora caninum	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium ulcerans	zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus multilocularis	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	IPR000718,Peptidase M13, neprilysin,domain-containing	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Onchocerca volvulus		Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Endothelin-converting enzyme 1	754 aa	705 aa	38.0 %
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	Endothelin-converting enzyme 1	754 aa	765 aa	20.8 %
Schistosoma japonicum	Endothelin-converting enzyme 2, putative	Endothelin-converting enzyme 1	754 aa	784 aa	23.3 %
Onchocerca volvulus		Endothelin-converting enzyme 1	754 aa	672 aa	31.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Echinococcus multilocularis	cathepsin b	0.1135	1	1
Onchocerca volvulus		0.017	0.0667	0.2808
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Brugia malayi	Papain family cysteine protease containing protein	0.019	0.086	0.086
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0239	0.1334	0.3296
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0339	0.2297	0.2297
Echinococcus multilocularis	cathepsin b	0.1135	1	1
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0114	0.0124	0.0124
Loa Loa (eye worm)	ctsf protein	0.0339	0.2297	0.2297
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0239	0.1334	0.1225
Loa Loa (eye worm)	hypothetical protein	0.017	0.0667	0.0667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0239	0.1334	0.2203
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0339	0.2297	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Onchocerca volvulus	Cathepsin F homolog	0.0339	0.2297	1
Echinococcus multilocularis	calpain A	0.0126	0.0242	0.012
Plasmodium vivax	vivapain-1	0.019	0.086	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0124	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1334	0.2203
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0412	0.301	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0667	0.0667
Loa Loa (eye worm)	calpain family protein 1	0.0121	0.0189	0.0189
Mycobacterium leprae	probable zinc metalloprotease	0.0114	0.0124	0.5
Onchocerca volvulus		0.0339	0.2297	1
Onchocerca volvulus		0.0339	0.2297	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0339	0.2297	0.6685
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0126	0.0242	0.012
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1317	0.1317
Brugia malayi	Cathepsin L-like precursor	0.0237	0.1317	0.1317
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0239	0.1334	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.019	0.086	0.086
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0239	0.1334	0.4193
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Giardia lamblia	Cathepsin B precursor	0.0412	0.301	1
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0486	0.3719	0.3719
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0339	0.2297	0.2201
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0339	0.2297	0.2201
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.2297	0.2297
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0412	0.301	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2297	1
Onchocerca volvulus		0.0237	0.1317	0.5676
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0667	0.0667
Onchocerca volvulus		0.0339	0.2297	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.2297	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0114	0.0124	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1135	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.1317	0.2127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1334	0.2203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0412	0.301	0.301
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0412	0.301	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0126	0.0242	0.0242
Loa Loa (eye worm)	fibroinase	0.0339	0.2297	0.2297
Brugia malayi	cathepsin L-like precursor	0.0237	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0057	0.0057
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Loa Loa (eye worm)	cathepsin B	0.0412	0.301	0.301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Loa Loa (eye worm)	cysteine protease	0.0339	0.2297	0.2297
Brugia malayi	Papain family cysteine protease containing protein	0.019	0.086	0.086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1135	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0339	0.2297	0.2201
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Echinococcus granulosus	cathepsin b	0.1135	1	1
Echinococcus granulosus	cathepsin l1	0.0339	0.2297	0.2201
Echinococcus multilocularis	cysteine protease	0.0339	0.2297	0.2201
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0486	0.3719	0.3719
Onchocerca volvulus		0.0339	0.2297	1
Brugia malayi	Papain family cysteine protease containing protein	0.0339	0.2297	0.2297
Treponema pallidum	ATP-dependent RNA helicase	0.0239	0.1334	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0339	0.2297	0.2201
Onchocerca volvulus		0.0339	0.2297	1
Plasmodium vivax	unspecified product	0.019	0.086	0.3744
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.019	0.086	0.086
Brugia malayi	eukaryotic initiation factor 4A	0.0239	0.1334	0.1334
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0239	0.1334	0.3296
Brugia malayi	Peptidase family M13 containing protein	0.0114	0.0124	0.0124
Echinococcus granulosus	cathepsin L cysteine protease	0.019	0.086	0.0746
Onchocerca volvulus	Cathepsin L homolog	0.0339	0.2297	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.2297	0.2297
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Toxoplasma gondii	cathepsin B	0.0412	0.301	1
Plasmodium vivax	vivapain-3	0.019	0.086	0.3744
Echinococcus granulosus	cysteine protease	0.019	0.086	0.0746
Leishmania major	cysteine peptidase A (CPA)	0.0339	0.2297	0.5748
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.2297	0.2297
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0237	0.1317	0.1317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0239	0.1334	0.1334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Giardia lamblia	Cathepsin B precursor	0.0412	0.301	1
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0239	0.1334	0.1225
Echinococcus granulosus	cathepsin b	0.1135	1	1
Plasmodium vivax	RNA helicase-1, putative	0.0239	0.1334	0.5806
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1317	0.1317
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Echinococcus granulosus	cathepsin l1	0.0237	0.1317	0.1209
Brugia malayi	Cathepsin L-like precursor	0.0237	0.1317	0.1317
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1135	1	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0124	0.0124
Brugia malayi	Trypsin family protein	0.017	0.0667	0.0667
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0239	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0124	0.0124
Trypanosoma cruzi	cysteine protease, putative	0.019	0.086	0.086
Loa Loa (eye worm)	hypothetical protein	0.0486	0.3719	0.3719
Schistosoma mansoni	cathepsin F (C01 family)	0.0339	0.2297	0.2297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1135	1	1
Loa Loa (eye worm)	hypothetical protein	0.1135	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0121	0.0189	0.0189
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.019	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Brugia malayi	calpain family protein 1	0.0121	0.0189	0.0189
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0339	0.2297	0.2297
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0239	0.1334	0.5748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0412	0.301	0.301
Trypanosoma cruzi	cysteine proteinase, putative	0.019	0.086	0.086
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.2297	1
Onchocerca volvulus		0.0339	0.2297	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0239	0.1334	0.1225
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0339	0.2297	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0239	0.1334	0.1225
Giardia lamblia	Cathepsin B precursor	0.0412	0.301	1
Plasmodium vivax	vivapain-2	0.0339	0.2297	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.0667	0.0667
Mycobacterium ulcerans	zinc metalloprotease	0.0114	0.0124	0.5
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0237	0.1317	0.1317
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1334	0.2203
Trypanosoma cruzi	cysteine peptidase, putative	0.019	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Onchocerca volvulus		0.0339	0.2297	1
Trypanosoma cruzi	cysteine proteinase, putative	0.019	0.086	0.086
Plasmodium vivax	vivapain-2	0.0339	0.2297	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0239	0.1334	0.1334
Onchocerca volvulus	Cathepsin L homolog	0.0339	0.2297	1
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0189	0.0189
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0239	0.1334	0.1334
Echinococcus granulosus	calpain A	0.0126	0.0242	0.012
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0339	0.2297	1
Brugia malayi	calpain family protein 1	0.0121	0.0189	0.0189
Echinococcus multilocularis	cathepsin L cysteine protease	0.0339	0.2297	0.2201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Trypanosoma cruzi	cruzipain precursor, putative	0.0339	0.2297	0.2297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.019	0.086	0.086
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1135	1	1
Loa Loa (eye worm)	hypothetical protein	0.0339	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1334	0.1334
Echinococcus multilocularis	cathepsin L	0.019	0.086	0.0746
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Echinococcus multilocularis	cathepsin L cysteine protease	0.0339	0.2297	0.2201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.1317	0.2127
Echinococcus multilocularis	cysteine protease	0.0339	0.2297	0.2201
Echinococcus granulosus	cathepsin L	0.019	0.086	0.0746
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.2297	0.6685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0339	0.2297	0.6685
Brugia malayi	Cathepsin L-like precursor	0.0339	0.2297	0.2297
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0126	0.0242	0.012
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0126	0.0242	0.0242
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0339	0.2297	0.6685
Entamoeba histolytica	cysteine proteinase, putative	0.0237	0.1317	0.3182
Schistosoma mansoni	cathepsin F (C01 family)	0.0339	0.2297	0.2297
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.2297	0.2297
Leishmania major	cathepsin L-like protease	0.0339	0.2297	0.5748
Schistosoma mansoni	cathepsin F (C01 family)	0.0237	0.1317	0.1317
Toxoplasma gondii	cathepsin CPL	0.0339	0.2297	0.7531

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 uM	Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells	ChEMBL.	No reference
IC50 (binding)	= 1.5 uM	Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 27696