Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0127 | 0.049 |
Onchocerca volvulus | 0.0179 | 0.1458 | 1 | |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0405 | 0.347 | 0.3361 |
Mycobacterium tuberculosis | Conserved protein | 0.0179 | 0.1458 | 0.1316 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0282 | 0.2375 | 0.2248 |
Echinococcus granulosus | geminin | 0.0168 | 0.1365 | 0.5283 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0198 | 0.0765 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0079 | 0.003 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0179 | 0.1458 | 0.2237 |
Mycobacterium tuberculosis | Conserved protein | 0.0179 | 0.1458 | 0.1316 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.0768 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0177 | 0.1444 | 0.1928 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0179 | 0.1458 | 0.2237 |
Brugia malayi | beta-lactamase | 0.0179 | 0.1458 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0679 | 0.59 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.0198 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.011 | 0.0425 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0179 | 0.1458 | 0.1316 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0725 | 0.6309 | 0.9454 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0179 | 0.1458 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.011 | 0.0425 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.011 | 0.0427 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0405 | 0.347 | 0.5061 |
Mycobacterium ulcerans | lipase LipD | 0.0179 | 0.1458 | 0.1949 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.006 | 0.0409 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0179 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0132 | 0.1041 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1365 | 0.5283 |
Trichomonas vaginalis | esterase, putative | 0.0179 | 0.1458 | 0.2237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0198 | 0.0222 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0127 | 0.0479 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0198 | 0.0765 |
Toxoplasma gondii | ABC1 family protein | 0.0179 | 0.1458 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0177 | 0.1444 | 0.2083 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0405 | 0.347 | 0.5379 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0179 | 0.1458 | 0.1316 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1365 | 0.5283 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0179 | 0.1458 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.0198 | 0.0766 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.006 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Schistosoma mansoni | lamin | 0.0027 | 0.011 | 0.0425 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.011 | 0.0425 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0073 | 0.0521 | 0.2016 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0179 | 0.1458 | 0.5643 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0179 | 0.1458 | 0.2237 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0198 | 0.0765 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0079 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0725 | 0.6309 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0179 | 0.1458 | 0.5643 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0198 | 0.099 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0198 | 0.1358 |
Plasmodium vivax | hypothetical protein, conserved | 0.0179 | 0.1458 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0106 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0725 | 0.6309 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0179 | 0.1458 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0079 | 0.137 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0305 | 0.2583 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0443 | 0.3807 | 0.5929 |
Mycobacterium ulcerans | beta-lactamase | 0.0179 | 0.1458 | 0.1949 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0079 | 0.003 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0079 | 0.0136 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0127 | 0.0489 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0063 | 0.0434 | 0.0274 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0079 | 0.0136 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.011 | 0.0756 |
Echinococcus granulosus | snurportin 1 | 0.0305 | 0.2583 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0179 | 0.1458 | 0.2237 |
Onchocerca volvulus | 0.0179 | 0.1458 | 1 | |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0595 | 0.408 |
Mycobacterium leprae | Probable lipase LipE | 0.0179 | 0.1458 | 0.2106 |
Trypanosoma brucei | beta lactamase | 0.0063 | 0.0434 | 0.2675 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.011 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.011 | 0.0427 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0127 | 0.0479 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0198 | 0.0222 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0179 | 0.1458 | 0.1316 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.0198 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.006 | 0.0231 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0179 | 0.1458 | 0.1316 |
Echinococcus granulosus | lamin | 0.0027 | 0.011 | 0.0425 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0063 | 0.0434 | 0.0365 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0198 | 0.0222 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0179 | 0.1458 | 0.5643 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0198 | 0.0765 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0725 | 0.6309 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0179 | 0.1458 | 1 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0679 | 0.59 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.006 | 0.0229 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium ulcerans | multidrug-transport integral membrane protein Mmr | 0.0193 | 0.1583 | 0.2142 |
Mycobacterium ulcerans | multidrugs-transport integral membrane protein Mmr-like | 0.0765 | 0.6662 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0179 | 0.1458 | 0.1316 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.011 | 0.0427 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.0198 | 0.1361 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0179 | 0.1458 | 0.2237 |
Loa Loa (eye worm) | beta-lactamase | 0.0179 | 0.1458 | 0.5644 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0179 | 0.1458 | 0.5644 |
Echinococcus multilocularis | snurportin 1 | 0.0305 | 0.2583 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.011 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0132 | 0.1041 | 0.1305 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1365 | 0.5283 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0073 | 0.0521 | 0.2016 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0226 | 0.1878 | 0.2789 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0198 | 0.0766 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0179 | 0.1458 | 1 |
Onchocerca volvulus | 0.0179 | 0.1458 | 1 | |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.011 | 0.0425 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0179 | 0.1458 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0127 | 0.0489 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.011 | 0.0425 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0179 | 0.1458 | 0.5643 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.0198 | 0.0992 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0443 | 0.3807 | 0.3704 |
Mycobacterium ulcerans | hypothetical protein | 0.0179 | 0.1458 | 0.1949 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Mycobacterium leprae | conserved hypothetical protein | 0.0179 | 0.1458 | 0.2106 |
Schistosoma mansoni | ran | 0.0021 | 0.006 | 0.0229 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.9972 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0226 | 0.1878 | 0.1743 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0679 | 0.59 | 0.0472 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0443 | 0.3807 | 0.5583 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0179 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0179 | 0.1458 | 0.1316 |
Schistosoma mansoni | ran | 0.0021 | 0.006 | 0.0229 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0179 | 0.1458 | 0.1316 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.0198 | 0.0766 |
Echinococcus multilocularis | lamin | 0.0027 | 0.011 | 0.0425 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0063 | 0.0434 | 0.0439 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0198 | 0.0766 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0198 | 0.0767 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0177 | 0.1444 | 0.1302 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0677 | 0.588 | 0.879 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0127 | 0.0479 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0127 | 0.0869 |
Brugia malayi | beta-lactamase family protein | 0.0179 | 0.1458 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0127 | 0.0489 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.2583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1458 | 0.5644 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0127 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0179 | 0.1458 | 0.1316 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 63.3 uM | In vitro inhibitory activity of the compound towards [3H]-cocaine binding to rat striatal tissue | ChEMBL. | 1995895 |
IC50 (binding) | = 63.3 uM | In vitro inhibitory activity of the compound towards [3H]-cocaine binding to rat striatal tissue | ChEMBL. | 1995895 |
IC50 (functional) | > 100 uM | Compound was evaluated in vitro, for the ability to inhibit [3H]- dopamine uptake into synaptosomes (prepared from rat striatal tissues). | ChEMBL. | 1995895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.