Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0079 | 0.137 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0079 | 0.003 |
Mycobacterium ulcerans | beta-lactamase | 0.0181 | 0.1458 | 0.1949 |
Trypanosoma brucei | beta lactamase | 0.0064 | 0.0434 | 0.2675 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.0595 | 0.408 |
Mycobacterium leprae | Probable lipase LipE | 0.0181 | 0.1458 | 0.2106 |
Onchocerca volvulus | 0.0181 | 0.1458 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0181 | 0.1458 | 0.2237 |
Echinococcus granulosus | snurportin 1 | 0.031 | 0.2583 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.011 | 0.0756 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0079 | 0.0136 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0127 | 0.0489 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0064 | 0.0434 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.011 | 0.0425 |
Plasmodium vivax | hypothetical protein, conserved | 0.0181 | 0.1458 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0198 | 0.1358 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0198 | 0.099 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.045 | 0.3807 | 0.5929 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.031 | 0.2583 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0079 | 0.003 |
Leishmania major | hypothetical protein, conserved | 0.0181 | 0.1458 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0736 | 0.6309 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0198 | 0.0765 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.1458 | 0.2237 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0181 | 0.1458 | 0.5643 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0074 | 0.0521 | 0.2016 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.011 | 0.0425 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0181 | 0.1458 | 0.5643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0736 | 0.6309 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0079 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.006 | 0.0229 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.0198 | 0.0766 |
Schistosoma mansoni | lamin | 0.0027 | 0.011 | 0.0425 |
Toxoplasma gondii | ABC1 family protein | 0.0181 | 0.1458 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0198 | 0.0765 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0127 | 0.0479 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0198 | 0.0222 |
Trichomonas vaginalis | esterase, putative | 0.0181 | 0.1458 | 0.2237 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1365 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0134 | 0.1041 | 0.0892 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0181 | 0.1458 | 0.1949 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0181 | 0.1458 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0181 | 0.1458 | 0.1316 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0412 | 0.347 | 0.5379 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.018 | 0.1444 | 0.2083 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0198 | 0.0766 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0106 | 0.041 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0181 | 0.1458 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0736 | 0.6309 | 0.9454 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0181 | 0.1458 | 0.1316 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.006 | 0.0409 |
Mycobacterium ulcerans | lipase LipD | 0.0181 | 0.1458 | 0.1949 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.011 | 0.0427 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0412 | 0.347 | 0.5061 |
Mycobacterium tuberculosis | Conserved protein | 0.0181 | 0.1458 | 0.1316 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0181 | 0.1458 | 0.2237 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0198 | 0.0765 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0079 | 0.0136 |
Echinococcus granulosus | geminin | 0.0171 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0286 | 0.2375 | 0.2248 |
Echinococcus multilocularis | musashi | 0.0027 | 0.011 | 0.0425 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.0198 | 1 |
Brugia malayi | beta-lactamase | 0.0181 | 0.1458 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.1458 | 0.2237 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.069 | 0.59 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0198 | 0.0768 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.018 | 0.1444 | 0.1928 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0412 | 0.347 | 0.3361 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0127 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Onchocerca volvulus | 0.0181 | 0.1458 | 1 | |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Conserved protein | 0.0181 | 0.1458 | 0.1316 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0127 | 0.0489 |
Brugia malayi | beta-lactamase family protein | 0.0181 | 0.1458 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0181 | 0.1458 | 0.1316 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.2583 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.011 | 0.0425 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.0198 | 0.0766 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0127 | 0.0869 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0127 | 0.0479 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0687 | 0.588 | 0.879 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.018 | 0.1444 | 0.1302 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0198 | 0.0766 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0198 | 0.0767 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0064 | 0.0434 | 0.0439 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.045 | 0.3807 | 0.5583 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0181 | 0.1458 | 0.1316 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0181 | 0.1458 | 0.1316 |
Schistosoma mansoni | ran | 0.0021 | 0.006 | 0.0229 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0181 | 0.1458 | 0.1949 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.045 | 0.3807 | 0.3704 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0198 | 0.0992 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.069 | 0.59 | 0.0472 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0229 | 0.1878 | 0.1743 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.9972 |
Schistosoma mansoni | ran | 0.0021 | 0.006 | 0.0229 |
Mycobacterium leprae | conserved hypothetical protein | 0.0181 | 0.1458 | 0.2106 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.0198 | 0.0992 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0181 | 0.1458 | 0.5643 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.011 | 0.0425 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0127 | 0.0489 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.1458 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.011 | 0.0425 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1365 | 0.5283 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0134 | 0.1041 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1458 | 0.5644 |
Schistosoma mansoni | lamin | 0.0027 | 0.011 | 0.0425 |
Echinococcus multilocularis | snurportin 1 | 0.031 | 0.2583 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0181 | 0.1458 | 0.5644 |
Loa Loa (eye worm) | beta-lactamase | 0.0181 | 0.1458 | 0.5644 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.1458 | 0.2237 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.0198 | 0.1361 |
Onchocerca volvulus | 0.0181 | 0.1458 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.1458 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0198 | 0.0766 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0229 | 0.1878 | 0.2789 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0074 | 0.0521 | 0.2016 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0198 | 0.0221 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.069 | 0.59 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0181 | 0.1458 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0198 | 0.0765 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0736 | 0.6309 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0181 | 0.1458 | 0.5643 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0198 | 0.0222 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0064 | 0.0434 | 0.0365 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.011 | 0.0427 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0181 | 0.1458 | 0.1316 |
Mycobacterium ulcerans | multidrugs-transport integral membrane protein Mmr-like | 0.0777 | 0.6662 | 1 |
Mycobacterium ulcerans | multidrug-transport integral membrane protein Mmr | 0.0196 | 0.1583 | 0.2142 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.0198 | 0.0766 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.006 | 0.0229 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0181 | 0.1458 | 0.1316 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0198 | 0.0222 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.011 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0 | 0.0002 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.011 | 0.0756 |
Echinococcus granulosus | lamin | 0.0027 | 0.011 | 0.0425 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0181 | 0.1458 | 0.1316 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0198 | 0.099 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.006 | 0.0231 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.0198 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC (functional) | = 9 | Average cytotoxic activity (AC) of the compound in three cancer cell lines A549, SK-MEL-2 and MCF-7 was calculated | ChEMBL. | 11844709 |
ED50 (functional) | = 8.1 nM | Cytotoxic activity of the compound against human human melanoma SK-MEL-2 was determined | ChEMBL. | 11844709 |
ED50 (functional) | = 8.1 nM | Cytotoxic activity of the compound against human human melanoma SK-MEL-2 was determined | ChEMBL. | 11844709 |
ED50 (functional) | = 9.1 nM | Cytotoxic activity of the compound against human breast cancer MCF-7 cell line was determined | ChEMBL. | 11844709 |
ED50 (functional) | = 9.1 nM | Cytotoxic activity of the compound against human breast cancer MCF-7 cell line was determined | ChEMBL. | 11844709 |
ED50 (functional) | = 9.8 nM | Cytotoxic activity of the compound against human lung cancer A549 cell line was determined | ChEMBL. | 11844709 |
ED50 (functional) | = 9.8 nM | Cytotoxic activity of the compound against human lung cancer A549 cell line was determined | ChEMBL. | 11844709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.