Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0066 | 0.0536 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1865 | 0.1865 |
Brugia malayi | ATP synthase delta chain, mitochondrial precursor, putative | 0.0116 | 0.2795 | 0.2795 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0066 | 0.0536 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 1 | 1 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0066 | 0.0536 | 0.0536 |
Chlamydia trachomatis | type III secretion system ATP synthase | 0.0066 | 0.0536 | 0.5 |
Toxoplasma gondii | ATP synthase F1 gamma subunit | 0.0095 | 0.1865 | 0.1405 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0213 | 0.7157 | 1 |
Brugia malayi | Subtilase family protein | 0.0219 | 0.7427 | 0.7427 |
Loa Loa (eye worm) | subtilase | 0.0219 | 0.7427 | 0.7427 |
Schistosoma mansoni | ATP synthase delta chain mitochondrial | 0.0116 | 0.2795 | 0.2795 |
Trypanosoma brucei | ATP synthase F1 subunit gamma protein, putative | 0.0095 | 0.1865 | 0.2701 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0066 | 0.0536 | 0.5 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0175 | 0.5458 | 1 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0213 | 0.7157 | 0.6996 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0213 | 0.7157 | 0.7157 |
Leishmania major | ATPase alpha subunit | 0.0175 | 0.5458 | 1 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0066 | 0.0536 | 0.5 |
Treponema pallidum | V-type ATP synthase subunit A | 0.0066 | 0.0536 | 0.5 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.0066 | 0.0536 | 0.0536 |
Trypanosoma cruzi | Mitochondrial ATP synthase epsilon chain, putative | 0.0094 | 0.1788 | 0.5544 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0213 | 0.7157 | 1 |
Loa Loa (eye worm) | ATP synthase subunit delta | 0.0116 | 0.2795 | 0.2795 |
Trypanosoma cruzi | ATP synthase, epsilon chain, putative | 0.0116 | 0.2795 | 1 |
Plasmodium vivax | ATP synthase subunit gamma, mitochondrial, putative | 0.0095 | 0.1865 | 0.1405 |
Treponema pallidum | flagellum-specific ATP synthase (fliI) | 0.0066 | 0.0536 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0219 | 0.7427 | 0.7427 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0213 | 0.7157 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0213 | 0.7157 | 0.7157 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0066 | 0.0536 | 0.0536 |
Toxoplasma gondii | ATP synthase, putative | 0.0116 | 0.2795 | 0.2387 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0066 | 0.0536 | 0.5 |
Echinococcus multilocularis | ATP synthase subunit delta, mitochondrial | 0.0116 | 0.2795 | 0.2795 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Plasmodium vivax | ATP synthase epsilon chain, mitochondrial , putative | 0.0276 | 1 | 1 |
Trypanosoma cruzi | Mitochondrial ATP synthase epsilon chain, putative | 0.0094 | 0.1788 | 0.5544 |
Plasmodium falciparum | ATP synthase subunit gamma, mitochondrial | 0.0095 | 0.1865 | 0.1405 |
Leishmania major | ATP synthase, epsilon chain, putative | 0.0116 | 0.2795 | 0.4589 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0066 | 0.0536 | 0.5 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC | 0.0116 | 0.2795 | 0.1757 |
Leishmania major | ATPase alpha subunit | 0.0175 | 0.5458 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0175 | 0.5458 | 1 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0082 | 0.1257 | 0.1257 |
Toxoplasma gondii | atp synthase F1, epsilon subunit, putative | 0.0276 | 1 | 1 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0213 | 0.7157 | 1 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0066 | 0.0536 | 0.0536 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0066 | 0.0536 | 0.0536 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0095 | 0.1865 | 0.5885 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0066 | 0.0536 | 0.0536 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0213 | 0.7157 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0213 | 0.7157 | 1 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Chlamydia trachomatis | V-type ATP synthase subunit A | 0.0066 | 0.0536 | 0.5 |
Echinococcus granulosus | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Mycobacterium tuberculosis | Probable ATP synthase epsilon chain AtpC | 0.0116 | 0.2795 | 0.1757 |
Trypanosoma brucei | mitochondrial ATP synthase delta chain | 0.0116 | 0.2795 | 0.4589 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0066 | 0.0536 | 0.0536 |
Echinococcus granulosus | 5'partial|ATP synthase subunit delta mitochondrial | 0.0116 | 0.2795 | 0.2795 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0066 | 0.0536 | 0.0536 |
Plasmodium vivax | hypothetical protein, conserved | 0.0116 | 0.2795 | 0.2387 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0066 | 0.0536 | 0.5 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Brugia malayi | ATP synthase gamma chain, mitochondrial precursor, putative | 0.0095 | 0.1865 | 0.1865 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0213 | 0.7157 | 0.7157 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0066 | 0.0536 | 0.0536 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0066 | 0.0536 | 0.5 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0066 | 0.0536 | 0.0536 |
Leishmania major | hypothetical protein, conserved | 0.0094 | 0.1788 | 0.2544 |
Leishmania major | ATP synthase F1 subunit gamma protein, putative | 0.0095 | 0.1865 | 0.2701 |
Echinococcus multilocularis | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0213 | 0.7157 | 0.6996 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0095 | 0.1865 | 0.5885 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit epsilon | 0.0116 | 0.2795 | 0.3412 |
Trypanosoma brucei | mitochondrial ATP synthase epsilon chain | 0.0094 | 0.1788 | 0.2544 |
Onchocerca volvulus | ATP synthase subunit gamma, mitochondrial homolog | 0.0095 | 0.1865 | 0.2606 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0082 | 0.1257 | 0.1257 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0066 | 0.0536 | 0.5 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0066 | 0.0536 | 0.5 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0213 | 0.7157 | 1 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0066 | 0.0536 | 0.0536 |
Echinococcus granulosus | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0276 | 1 | 1 |
Treponema pallidum | V-type ATP synthase subunit A | 0.0066 | 0.0536 | 0.5 |
Plasmodium falciparum | ATP synthase subunit delta, mitochondrial, putative | 0.0116 | 0.2795 | 0.2387 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit gamma | 0.0095 | 0.1865 | 0.2008 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0066 | 0.0536 | 0.0536 |
Loa Loa (eye worm) | ATP synthase subunit epsilon | 0.0276 | 1 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit epsilon | 0.0116 | 0.2795 | 0.3412 |
Chlamydia trachomatis | type III secretion system ATPase | 0.0066 | 0.0536 | 0.5 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0066 | 0.0536 | 0.0536 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0213 | 0.7157 | 0.7157 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit gamma | 0.0095 | 0.1865 | 0.2008 |
Echinococcus multilocularis | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0276 | 1 | 1 |
Trichomonas vaginalis | ATP synthase, putative | 0.0066 | 0.0536 | 0.5 |
Onchocerca volvulus | ATP synthase subunit delta, mitochondrial homolog | 0.0116 | 0.2795 | 0.3905 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0095 | 0.1865 | 0.1865 |
Plasmodium falciparum | mitochondrial ATP synthase F1, epsilon subunit, putative | 0.0276 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39 uM | Inhibition of neutrophil release in rat adjuvant arthritis model as measure of antiinflammatory activity | ChEMBL. | 3104589 |
Inhibition (functional) | = 43 % | Anti-inflammatory activity (% inhibition of paw swelling)in rat adjuvant arthritis model at 25 mg/kg oral dose | ChEMBL. | 3104589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.