Detailed information for compound 279105

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.5 | Formula: C25H26N4O2
  • H donors: 3 H acceptors: 2 LogP: 3.52 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](c1ccccc1)NC(=O)c1cccc(c1)C(=N)N)NCCCc1ccccc1
  • InChi: 1S/C25H26N4O2/c26-23(27)20-14-7-15-21(17-20)24(30)29-22(19-12-5-2-6-13-19)25(31)28-16-8-11-18-9-3-1-4-10-18/h1-7,9-10,12-15,17,22H,8,11,16H2,(H3,26,27)(H,28,31)(H,29,30)/t22-/m1/s1
  • InChiKey: VMXRENPUUIMQCX-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0196 0.0521
Brugia malayi Pyruvate kinase, M2 isozyme 0.0031 0.0068 0.0055
Schistosoma mansoni caspase-7 (C14 family) 0.0024 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0137 0.0913 0.0901
Trypanosoma cruzi metacaspase, putative 0.0024 0.0019 0.0005
Echinococcus granulosus cathepsin L cysteine proteinase 0.0389 0.2922 0.2913
Giardia lamblia Fructose-bisphosphate aldolase 0.0267 0.1954 0.5517
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Loa Loa (eye worm) hypothetical protein 0.0068 0.0368 0.0355
Loa Loa (eye worm) hypothetical protein 0.0103 0.0649 0.0636
Brugia malayi calpain family protein 1 0.0117 0.0754 0.0742
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0024 0.0019 0.0053
Leishmania major pyruvate kinase 0.0031 0.0068 0.0156
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1278 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0267 0.1954 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.021 0.1498 0.1487
Brugia malayi Muscleblind-like protein 0.0137 0.0913 0.0901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0101 0.0633 0.1763
Leishmania major cysteine peptidase A (CPA) 0.0389 0.2922 0.8272
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.005 0.0221 0.0208
Echinococcus granulosus eukaryotic initiation factor 4A 0.021 0.1498 0.1487
Echinococcus granulosus microtubule associated protein 2 0.0631 0.485 0.4844
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0026 0.0034 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Echinococcus granulosus calpain A 0.0044 0.0176 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0068 0.0368 0.0355
Schistosoma mansoni SET domain protein 0.003 0.0064 0.0051
Echinococcus granulosus pyruvate kinase 0.0031 0.0068 0.0055
Loa Loa (eye worm) hypothetical protein 0.0086 0.0509 0.0496
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.1561 0.4401
Entamoeba histolytica hypothetical protein 0.0033 0.0087 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Trypanosoma cruzi metacaspase, putative 0.0024 0.0019 0.0005
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Echinococcus granulosus 6 phosphofructokinase 0.0099 0.0617 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0218 0.1561 0.155
Schistosoma mansoni pyruvate kinase 0.0031 0.0068 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0272 0.1994 0.5633
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0066 0.035 0.1185
Onchocerca volvulus Cathepsin F homolog 0.0389 0.2922 1
Mycobacterium ulcerans hypothetical protein 0.0068 0.0368 0.3758
Brugia malayi cathepsin L-like precursor 0.0272 0.1994 0.1984
Brugia malayi cathepsin F-like cysteine proteinase 0.0101 0.0633 0.0621
Plasmodium vivax sentrin-specific protease 2, putative 0.0024 0.0013 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0101 0.0633 0.1763
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0617 0.1716
Trypanosoma brucei metacaspase MCA2 0.0024 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0633 0.1763
Leishmania major kinesin, putative 0.0031 0.007 0.0162
Plasmodium vivax calpain, putative 0.0044 0.0176 0.0588
Toxoplasma gondii cathepsin CPL 0.0389 0.2922 0.8278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Brugia malayi 6-phosphofructokinase 0.0099 0.0617 0.0604
Onchocerca volvulus 0.0389 0.2922 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Echinococcus multilocularis enteropeptidase 0.0068 0.0368 0.0355
Trypanosoma cruzi hypothetical protein 0.0073 0.0403 0.039
Trypanosoma cruzi cysteine proteinase, putative 0.0218 0.1561 0.155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0218 0.1561 0.155
Schistosoma mansoni hypothetical protein 0.0066 0.035 0.0337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0005
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.021 0.1498 0.5104
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0196 0.0183
Schistosoma mansoni cathepsin F (C01 family) 0.0389 0.2922 0.2913
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1278 1 1
Echinococcus granulosus calpain 5 0.0044 0.0176 0.0163
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0101 0.0633 0.0621
Leishmania major eukaryotic initiation factor 4a, putative 0.021 0.1498 0.4222
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0068 0.0368 0.0355
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0197 0.0184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus granulosus neuropeptide receptor A26 0.0423 0.3193 0.3184
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0087 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Echinococcus multilocularis polycomb protein SCMH1 0.0044 0.0173 0.016
Loa Loa (eye worm) Ulp1 protease 0.0073 0.0403 0.039
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0101 0.0633 0.2156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus granulosus tissue type plasminogen activator 0.0066 0.035 0.0337
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0176 0.0462
Trypanosoma cruzi cruzipain precursor, putative 0.0389 0.2922 0.2913
Echinococcus granulosus cathepsin b 0.1278 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0024 0.0019 0.0005
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0122 0.0796 0.0784
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0633 0.0621
Brugia malayi Trypsin family protein 0.0068 0.0368 0.0355
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0068 0.0368 0.0355
Plasmodium vivax sentrin-specific protease 1, putative 0.0024 0.0013 0.0032
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0027 0.0039 0.0111
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0026 0.0034 0.0071
Brugia malayi mbt repeat family protein 0.0044 0.0173 0.016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Echinococcus granulosus caspase 0.0091 0.0548 0.0536
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0101 0.0633 0.1763
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Entamoeba histolytica protein kinase, putative 0.0031 0.0074 0.0208
Echinococcus granulosus cathepsin l1 0.0272 0.1994 0.1984
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0172 0.1194 0.1182
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Onchocerca volvulus Cell death protein 3 homolog 0.0024 0.0019 0.0019
Brugia malayi eukaryotic initiation factor 4A 0.021 0.1498 0.1487
Trypanosoma cruzi kinesin, putative 0.0031 0.007 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0633 0.1763
Loa Loa (eye worm) hypothetical protein 0.0044 0.0173 0.016
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.0633 0.0621
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0099 0.0617 0.1716
Onchocerca volvulus 0.0068 0.0368 0.1218
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.021 0.1498 0.1487
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0117 0.0754 0.0742
Echinococcus multilocularis pyruvate kinase 0.0031 0.0068 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0055
Onchocerca volvulus Cathepsin L homolog 0.0101 0.0633 0.2131
Plasmodium falciparum serine repeat antigen 9 0.0101 0.0633 0.2131
Entamoeba histolytica hypothetical protein 0.0033 0.0087 0.0255
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0101 0.0633 0.2156
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0044 0.0173 0.016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0389 0.2922 0.2913
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Giardia lamblia Translation initiation factor eIF-4A, putative 0.021 0.1498 0.4222
Echinococcus multilocularis hypothetical protein 0.0044 0.0176 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.1561 0.4401
Brugia malayi cathepsin L precursor 0.0101 0.0633 0.0621
Trypanosoma cruzi metacaspase, putative 0.0024 0.0019 0.0005
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0267 0.1954 0.667
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Plasmodium falciparum serine repeat antigen 3 0.0101 0.0633 0.2131
Loa Loa (eye worm) MBCTL1 0.005 0.0221 0.0208
Trypanosoma brucei cysteine peptidase C (CPC) 0.0465 0.353 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0053 0.0112
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0122 0.0796 0.0784
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0389 0.2922 0.2913
Schistosoma mansoni pyruvate kinase 0.0031 0.0068 0.0055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Echinococcus multilocularis caspase 2 0.0024 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.021 0.1498 0.1487
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0091 0.0548 0.0536
Echinococcus multilocularis cathepsin b 0.1278 1 1
Echinococcus granulosus transmembrane protease serine 3 0.0068 0.0368 0.0355
Toxoplasma gondii preprocathepsin c precursor, putative 0.0101 0.0633 0.1794
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.0633 0.2156
Echinococcus multilocularis neuropeptide s receptor 0.0423 0.3193 0.3184
Trypanosoma brucei protein kinase, putative 0.0047 0.0196 0.0521
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0633 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0196 0.0183
Echinococcus granulosus cathepsin b 0.1278 1 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.021 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0047 0.0196 0.0521
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.0633 0.2156
Echinococcus multilocularis microtubule associated protein 2 0.0631 0.485 0.4844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Entamoeba histolytica cysteine proteinase, putative 0.0389 0.2922 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0633 0.0621
Echinococcus multilocularis SAM and MBT domain containing protein 0.0044 0.0173 0.016
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0091 0.0548 0.0536
Echinococcus multilocularis caspase 0.0091 0.0548 0.0536
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0024 0.0019 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0633 0.0621
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0196 0.0521
Plasmodium vivax vivapain-1 0.0218 0.1561 0.5336
Loa Loa (eye worm) hypothetical protein 0.0068 0.0368 0.0355
Plasmodium vivax 6-phosphofructokinase, putative 0.0027 0.0039 0.0121
Echinococcus granulosus mitogen activated protein kinase 0.0047 0.0196 0.0183
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0047 0.0196 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Loa Loa (eye worm) RecQ helicase 0.0038 0.0125 0.0112
Giardia lamblia Hypothetical protein 0.0101 0.0633 0.1763
Plasmodium vivax vivapain-2 0.0389 0.2922 1
Trypanosoma cruzi cruzipain precursor, putative 0.0117 0.0753 0.0741
Toxoplasma gondii cathepsin CPC2 0.0101 0.0633 0.1794
Onchocerca volvulus 0.0272 0.1994 0.681
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0101 0.0633 0.2156
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0462
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.0617 0.2075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0633 0.0621
Loa Loa (eye worm) hypothetical protein 0.0174 0.1215 0.1203
Loa Loa (eye worm) fibroinase 0.0389 0.2922 0.2913
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Loa Loa (eye worm) TK/ROR protein kinase 0.0066 0.035 0.0337
Brugia malayi Papain family cysteine protease containing protein 0.0218 0.1561 0.155
Schistosoma mansoni hypothetical protein 0.0068 0.0368 0.0355
Leishmania major ATP-dependent phosphofructokinase 0.0099 0.0617 0.1716
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1278 1 1
Echinococcus granulosus Mastin 0.0068 0.0368 0.0355
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Brugia malayi Cathepsin L-like precursor 0.0117 0.0753 0.0741
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0117 0.0753 0.0741
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0026 0.0034 0.0021
Echinococcus granulosus cathepsin L 0.0218 0.1561 0.155
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.1561 0.5321
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0131 0.0865 0.5573
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0026 0.0034 0.0021
Entamoeba histolytica calpain large subunit domain III containing protein 0.0031 0.007 0.0196
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0053 0.0112
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0024 0.0013 0.0038
Brugia malayi Kringle domain containing protein 0.0066 0.035 0.0337
Echinococcus multilocularis sentrin specific protease 8 0.0073 0.0403 0.039
Onchocerca volvulus 0.0068 0.0368 0.1218
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Schistosoma mansoni 6-phosphofructokinase 0.0099 0.0617 0.0604
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0163
Brugia malayi Trypsin family protein 0.0068 0.0368 0.0355
Trypanosoma cruzi pyruvate kinase 2, putative 0.0031 0.0068 0.0055
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.1561 0.4401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Loa Loa (eye worm) hypothetical protein 0.0272 0.1994 0.1984
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0101 0.0633 0.2156
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.021 0.1498 0.4243
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0099 0.0617 0.3837
Onchocerca volvulus 0.0068 0.0368 0.1218
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0197 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0176 0.0163
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0163
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0163
Giardia lamblia Hypothetical protein 0.0101 0.0633 0.1763
Brugia malayi cathepsin F-like cysteine proteinase 0.0117 0.0753 0.0741
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus granulosus caspase 8 0.0024 0.0019 0.0005
Plasmodium vivax pyruvate kinase, putative 0.0031 0.0068 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Echinococcus multilocularis glycoprotein Antigen 5 0.0068 0.0368 0.0355
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0389 0.2922 0.2913
Onchocerca volvulus 0.0389 0.2922 1
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Loa Loa (eye worm) pyruvate kinase 0.0031 0.0068 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.0068 0.0189
Echinococcus multilocularis pyruvate kinase 0.0024 0.0017 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Loa Loa (eye worm) hypothetical protein 0.0068 0.0368 0.0355
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Echinococcus multilocularis 6 phosphofructokinase 0.0099 0.0617 0.0604
Onchocerca volvulus Cathepsin L homolog 0.0389 0.2922 1
Echinococcus multilocularis neuropeptide receptor A26 0.0423 0.3193 0.3184
Giardia lamblia Cathepsin B precursor 0.0101 0.0633 0.1763
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0053 0.0112
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Echinococcus multilocularis cysteine protease 0.0389 0.2922 0.2913
Plasmodium vivax 6-phosphofructokinase, putative 0.0027 0.0039 0.0121
Echinococcus granulosus pyruvate kinase 0.0031 0.0068 0.0055
Plasmodium falciparum serine repeat antigen 7 0.0101 0.0633 0.2131
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0026 0.0034 0.0021
Echinococcus multilocularis mitogen activated protein kinase 3 0.0047 0.0196 0.0183
Entamoeba histolytica hypothetical protein 0.0033 0.0087 0.0255
Loa Loa (eye worm) calpain family protein 1 0.0117 0.0754 0.0742
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Loa Loa (eye worm) cysteine protease 0.0389 0.2922 0.2913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.0753 0.0741
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.001
Echinococcus granulosus caspase 2 0.0024 0.0019 0.0005
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0024 0.0013 0.0038
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0462
Echinococcus granulosus neuropeptide s receptor 0.0423 0.3193 0.3184
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Schistosoma mansoni calpain (C02 family) 0.0044 0.0176 0.0163
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Loa Loa (eye worm) ctsf protein 0.0389 0.2922 0.2913
Entamoeba histolytica cysteine proteinase, putative 0.0272 0.1994 0.681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus granulosus cathepsin L cysteine protease 0.0218 0.1561 0.155
Giardia lamblia Cathepsin L-like protease 0.0101 0.0633 0.1763
Entamoeba histolytica hypothetical protein 0.0101 0.0633 0.2131
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0047 0.0196 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0617 0.1716
Schistosoma mansoni 6-phosphofructokinase 0.0099 0.0617 0.0604
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.021 0.1498 0.4222
Brugia malayi Trypsin-like protease protein 5 0.0068 0.0368 0.0355
Plasmodium vivax vivapain-2 0.0389 0.2922 1
Echinococcus granulosus caspase 3 0.0067 0.0355 0.0342
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0173 0.016
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0099 0.0617 0.3017
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.1561 0.5321
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.021 0.1498 0.1487
Plasmodium falciparum cysteine proteinase falcipain 3 0.0389 0.2922 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0027 0.0039 0.0089
Brugia malayi Trypsin family protein 0.0068 0.0368 0.0355
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.005 0.0221 0.0208
Brugia malayi Cathepsin L-like cysteine proteinase 0.0272 0.1994 0.1984
Schistosoma mansoni microtubule-associated protein tau 0.0631 0.485 0.4844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Brugia malayi hypothetical protein 0.0033 0.0087 0.0074
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0099 0.0617 0.6885
Echinococcus granulosus histone acetyltransferase MYST2 0.005 0.0221 0.0208
Echinococcus granulosus cysteine protease 0.0218 0.1561 0.155
Toxoplasma gondii cathepsin CPC1 0.0101 0.0633 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0019 0.005
Entamoeba histolytica cysteine proteinase 2 0.0218 0.1561 0.5321
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0633 0.0621
Echinococcus multilocularis mitogen activated protein kinase 0.0047 0.0196 0.0183
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0633 0.0621
Toxoplasma gondii kringle domain-containing protein 0.0066 0.035 0.0991
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Loa Loa (eye worm) hypothetical protein 0.0117 0.0753 0.0741
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.021 0.1498 0.1487
Onchocerca volvulus 0.0389 0.2922 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0024 0.0019 0.0005
Brugia malayi Protein kinase domain containing protein 0.0066 0.035 0.0337
Loa Loa (eye worm) hypothetical protein 0.0272 0.1994 0.1984
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0465 0.353 1
Toxoplasma gondii cathepsin B 0.0465 0.353 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0101 0.0633 0.0621
Plasmodium vivax serine-repeat antigen (SERA) 0.0101 0.0633 0.2156
Brugia malayi Cell death protein 3 precursor 0.0024 0.0019 0.0005
Leishmania major pyruvate kinase 0.0031 0.0068 0.0156
Loa Loa (eye worm) 6-phosphofructokinase 0.0099 0.0617 0.0604
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Loa Loa (eye worm) calpain 0.0044 0.0176 0.0163
Plasmodium falciparum serine repeat antigen 8 0.0101 0.0633 0.2131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0633 0.0621
Echinococcus multilocularis cathepsin L 0.0101 0.0633 0.0621
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0068 0.0368 0.0355
Echinococcus multilocularis pyruvate kinase 0.0031 0.0068 0.0055
Echinococcus multilocularis cathepsin L cysteine protease 0.0389 0.2922 0.2913
Trypanosoma cruzi metacaspase, putative 0.0024 0.0019 0.0005
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Trypanosoma cruzi cysteine peptidase, putative 0.0389 0.2922 0.2913
Schistosoma mansoni hypothetical protein 0.0068 0.0368 0.0355
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Trypanosoma brucei metacaspase 5, putative 0.0024 0.0019 0.0015
Trichomonas vaginalis DNA helicase recq1, putative 0.0038 0.0125 0.0318
Loa Loa (eye worm) hypothetical protein 0.0066 0.035 0.0337
Plasmodium falciparum cysteine proteinase falcipain 1 0.0218 0.1561 0.5321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Giardia lamblia Cathepsin B precursor 0.0465 0.353 1
Onchocerca volvulus 0.0389 0.2922 1
Brugia malayi calpain 7 0.0044 0.0176 0.0163
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0101 0.0633 0.0621
Echinococcus granulosus cathepsin l1 0.0389 0.2922 0.2913
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Echinococcus granulosus mitogen activated protein kinase 3 0.0047 0.0196 0.0183
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0163
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Trichomonas vaginalis pyruvate kinase, putative 0.0031 0.0068 0.0156
Plasmodium falciparum serine repeat antigen 5 0.0101 0.0633 0.2131
Schistosoma mansoni DNA helicase recq1 0.0026 0.0034 0.0021
Echinococcus granulosus eukaryotic initiation factor 4A III 0.021 0.1498 0.1487
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Loa Loa (eye worm) DEAH box polypeptide 35 0.0471 0.3577 0.3568
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.1561 0.5321
Schistosoma mansoni myelin transcription factor 1 myt1 0.005 0.0221 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0389 0.2922 0.2913
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Schistosoma mansoni hypothetical protein 0.0265 0.1937 0.1926
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0176 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0196 0.0521
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Trypanosoma cruzi metacaspase 5, putative 0.0024 0.0019 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0038 0.0125 0.0112
Echinococcus granulosus SAM and MBT domain containing protein 0.0044 0.0173 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0633 0.1763
Brugia malayi Cathepsin L-like precursor 0.0272 0.1994 0.1984
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0163
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0174 0.1215 0.1203
Brugia malayi Pyruvate kinase, muscle isozyme 0.0031 0.0068 0.0055
Echinococcus multilocularis transmembrane protease serine 3 0.0068 0.0368 0.0355
Loa Loa (eye worm) hypothetical protein 0.1278 1 1
Trypanosoma brucei Metacaspase-4 0.0024 0.0019 0.0015
Giardia lamblia Cysteine protease 0.0101 0.0633 0.1763
Onchocerca volvulus 0.0389 0.2922 1
Toxoplasma gondii phosphofructokinase PFKII 0.0027 0.0039 0.0111
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0403 0.1108
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Leishmania major metacaspase, putative 0.0024 0.0019 0.0015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0122 0.0796 0.0784
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0633 0.1763
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.035 0.0337
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0073 0.0403 0.039
Brugia malayi 6-phosphofructokinase 0.0099 0.0617 0.0604
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0176 0.0462
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Echinococcus multilocularis cathepsin L cysteine protease 0.0389 0.2922 0.2913
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0087 0.0074
Mycobacterium ulcerans 6-phosphofructokinase 0.0099 0.0617 0.6885
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0196 0.0183
Onchocerca volvulus 0.0106 0.0672 0.2266
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Brugia malayi calpain family protein 1 0.0117 0.0754 0.0742
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0218 0.1561 0.155
Loa Loa (eye worm) pyruvate kinase 0.0031 0.0068 0.0055
Echinococcus granulosus calpain 7 C02 family 0.0044 0.0176 0.0163
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0267 0.1954 0.667
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0101 0.0633 0.2131
Brugia malayi phosphofructokinase 0.0099 0.0617 0.0604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Echinococcus multilocularis caspase 3 0.0067 0.0355 0.0342
Echinococcus multilocularis muscleblind protein 0.0137 0.0913 0.0901
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0026 0.0034 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.1561 0.5321
Loa Loa (eye worm) mbt repeat family protein 0.0044 0.0173 0.016
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0101 0.0633 0.2156
Echinococcus multilocularis bloom syndrome protein 0.0038 0.0125 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0633 0.1763
Plasmodium vivax metacaspase 1, putative 0.0024 0.0019 0.005
Plasmodium falciparum serine repeat antigen 4 0.0101 0.0633 0.2131
Loa Loa (eye worm) hypothetical protein 0.0117 0.0753 0.0741
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.2922 0.2913
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0024 0.0019 0.0053
Loa Loa (eye worm) calpain 5 0.0031 0.007 0.0057
Plasmodium falciparum eukaryotic initiation factor 4A 0.021 0.1498 0.5104
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0101 0.0633 0.2131
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0101 0.0633 0.2156
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.0633 0.1763
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Loa Loa (eye worm) 6-phosphofructokinase 0.0099 0.0617 0.0604
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0117 0.0753 0.0741
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0389 0.2922 1
Plasmodium vivax unspecified product 0.0117 0.0753 0.2568
Trichomonas vaginalis Sentrin-specific protease, putative 0.0073 0.0403 0.1108
Onchocerca volvulus 0.0073 0.0404 0.1342
Loa Loa (eye worm) phosphofructokinase 0.0099 0.0617 0.0604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Plasmodium falciparum cysteine repeat modular protein 1 0.0066 0.035 0.1157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0633 0.1763
Trypanosoma brucei antigen, putative 0.0044 0.0176 0.0462
Schistosoma mansoni DNA helicase recq5 0.0026 0.0034 0.0021
Treponema pallidum ATP-dependent RNA helicase 0.021 0.1498 0.762
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0173 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Trypanosoma cruzi cysteine protease, putative 0.0218 0.1561 0.155
Onchocerca volvulus 0.0389 0.2922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.0633 0.2131
Trypanosoma brucei metacaspase 0.0024 0.0019 0.0015
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.0068 0.0189
Chlamydia trachomatis pyruvate kinase 0.0031 0.0068 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0101 0.0633 0.2156
Loa Loa (eye worm) pyruvate kinase 0.0031 0.0068 0.0055
Onchocerca volvulus 0.0068 0.0368 0.1218
Schistosoma mansoni Mername-AA248 (C02 family) 0.0044 0.0176 0.0163
Plasmodium falciparum serine repeat antigen 2 0.0101 0.0633 0.2131
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0053 0.0136
Loa Loa (eye worm) hypothetical protein 0.0117 0.0753 0.0741
Giardia lamblia Sgs1 DNA helicase, putative 0.0026 0.0034 0.0059
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0034 0.0021
Loa Loa (eye worm) calpain family protein 1 0.0086 0.0509 0.0496
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.1561 0.155
Loa Loa (eye worm) hypothetical protein 0.0068 0.0368 0.0355
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0368 0.0355
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0027 0.0039 0.0074
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0047 0.0196 0.0183
Brugia malayi Trypsin family protein 0.0174 0.1215 0.1203
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Loa Loa (eye worm) hypothetical protein 0.0174 0.1215 0.1203
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0034 0.0021
Echinococcus granulosus calpain 0.0044 0.0176 0.0163
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Trypanosoma cruzi kinesin, putative 0.0031 0.007 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0125 0.0318
Echinococcus granulosus muscleblind protein 0.0137 0.0913 0.0901
Giardia lamblia Kinase, CMGC MAPK 0.0047 0.0196 0.0521
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.0068 0.0189
Echinococcus multilocularis caspase 8 0.0024 0.0019 0.0005
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0024 0.0013 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Brugia malayi fibroinase precursor 0.0101 0.0633 0.0621
Brugia malayi Probable ATP-dependent helicase DHX35 0.0471 0.3577 0.3568
Onchocerca volvulus 0.0068 0.0368 0.1218
Plasmodium falciparum serine repeat antigen 6 0.0101 0.0633 0.2131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0462
Brugia malayi mbt repeat family protein 0.0044 0.0173 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Echinococcus granulosus sentrin specific protease 8 0.0073 0.0403 0.039
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.0633 0.1763
Echinococcus multilocularis calpain 5 0.0044 0.0176 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Leishmania major hypothetical protein, conserved 0.0066 0.035 0.0957
Plasmodium falciparum serine repeat antigen 1 0.0101 0.0633 0.2131
Onchocerca volvulus Cathepsin L homolog 0.0389 0.2922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0633 0.1763
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1278 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0389 0.2922 0.2913
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0024 0.0019 0.0053
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Brugia malayi cathepsin Z-like cysteine proteinase 0.0101 0.0633 0.0621
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0035 0.0106 0.032
Echinococcus multilocularis histone acetyltransferase MYST2 0.005 0.0221 0.0208
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0101 0.0633 0.2156
Giardia lamblia Cathepsin L-like protease 0.0101 0.0633 0.1763
Trypanosoma brucei pyruvate kinase 1 0.0031 0.0068 0.0156
Giardia lamblia Encystation-specific protease 0.0101 0.0633 0.1763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0465 0.353 0.3522
Echinococcus granulosus calpain A 0.0122 0.0796 0.0784
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0196 0.0521
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0163
Giardia lamblia Cysteine protease 0.0101 0.0633 0.1763
Trichomonas vaginalis pyruvate kinase, putative 0.0031 0.0068 0.0156
Loa Loa (eye worm) cathepsin B 0.0465 0.353 0.3522
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0163
Giardia lamblia Cysteine protease 0.0101 0.0633 0.1763
Trypanosoma brucei metacaspase MCA3 0.0024 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0633 0.1763
Trypanosoma brucei kinesin, putative 0.0031 0.007 0.0162
Echinococcus granulosus bloom syndrome protein 0.0038 0.0125 0.0112
Plasmodium falciparum metacaspase 1 0.0024 0.0019 0.0019
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0176 0.0462
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0174 0.1215 0.1203
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0027 0.0039 0.0074
Plasmodium falciparum metacaspase-like protein 0.0024 0.0019 0.0019
Echinococcus multilocularis calpain A 0.0122 0.0796 0.0784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Giardia lamblia Cysteine protease 0.0101 0.0633 0.1763
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0027 0.0039 0.0089
Giardia lamblia Cathepsin B precursor 0.0101 0.0633 0.1763
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.2922 0.8272
Giardia lamblia Cathepsin B precursor 0.0101 0.0633 0.1763
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Brugia malayi MAP kinase sur-1 0.0047 0.0196 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0034 0.0096
Trypanosoma cruzi cysteine proteinase, putative 0.0218 0.1561 0.155
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0633 0.0621
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.0633 0.0621
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0027 0.0039 0.4717
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.0633 0.1763
Giardia lamblia Cathepsin B precursor 0.0101 0.0633 0.1763
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0131 0.0865 1
Giardia lamblia Cathepsin B precursor 0.0101 0.0633 0.1763
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0122 0.0796 0.0784
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0101 0.0633 0.1763
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0403 0.1108
Echinococcus multilocularis calpain 7 (C02 family) 0.0044 0.0176 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Loa Loa (eye worm) hypothetical protein 0.0101 0.0633 0.0621
Loa Loa (eye worm) hypothetical protein 0.0117 0.0754 0.0742
Echinococcus multilocularis tissue type plasminogen activator 0.0066 0.035 0.0337
Entamoeba histolytica cysteine protease, putative 0.0101 0.0633 0.2131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus multilocularis muscleblind protein 1 0.0137 0.0913 0.0901
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0633 0.0621
Onchocerca volvulus 0.0174 0.1215 0.413
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0019 0.0015
Echinococcus granulosus cathepsin L 0.0101 0.0633 0.0621
Schistosoma mansoni cathepsin s 0.0117 0.0753 0.0741
Loa Loa (eye worm) hypothetical protein 0.0073 0.0404 0.0391
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1278 1 1
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Giardia lamblia Pyruvate kinase 0.0031 0.0068 0.0156
Plasmodium falciparum pyruvate kinase 0.0031 0.0068 0.0189
Giardia lamblia Cathepsin B precursor 0.0465 0.353 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0368 0.0355
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0027 0.0039 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0465 0.353 1
Entamoeba histolytica cysteine proteinase, putative 0.0389 0.2922 1
Schistosoma mansoni cathepsin S (C01 family) 0.0101 0.0633 0.0621
Plasmodium vivax RNA helicase-1, putative 0.021 0.1498 0.5119
Giardia lamblia Cathepsin B precursor 0.0465 0.353 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0131 0.0865 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0101 0.0633 0.2131
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Echinococcus multilocularis cysteine protease 0.0389 0.2922 0.2913
Plasmodium vivax unspecified product 0.0218 0.1561 0.5336
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.005 0.0221 0.0208
Loa Loa (eye worm) hypothetical protein 0.0272 0.1994 0.1984
Onchocerca volvulus 0.0044 0.0173 0.0548
Entamoeba histolytica hypothetical protein 0.0033 0.0087 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Echinococcus granulosus polycomb protein SCMH1 0.0044 0.0173 0.016
Toxoplasma gondii pyruvate kinase PyK1 0.0031 0.0068 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0101 0.0633 0.1763
Toxoplasma gondii 6-phosphofructokinase 0.0027 0.0039 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0087 0.0074
Plasmodium vivax vivapain-3 0.0218 0.1561 0.5336
Schistosoma mansoni hypothetical protein 0.0033 0.0087 0.0074
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.0617 0.2075
Entamoeba histolytica cysteine proteinase 1, putative 0.0218 0.1561 0.5321
Leishmania major cathepsin L-like protease 0.0389 0.2922 0.8272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0101 0.0633 0.1763
Brugia malayi calpain 5 0.0031 0.007 0.0057
Onchocerca volvulus 0.0389 0.2922 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0368 0.0355
Loa Loa (eye worm) trypsin family protein 0.0068 0.0368 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0389 0.2922 0.2913
Schistosoma mansoni cathepsin C 0.0101 0.0633 0.0621
Echinococcus multilocularis cathepsin L 0.0218 0.1561 0.155
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.003 0.0064 0.0051
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0101 0.0633 0.2156
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0053 0.0039
Echinococcus multilocularis cathepsin b 0.1278 1 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.021 0.1498 0.1487
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0047 0.0196 0.0557
Echinococcus granulosus enteropeptidase 0.0068 0.0368 0.0355
Schistosoma mansoni blooms syndrome DNA helicase 0.0024 0.0019 0.0006
Trypanosoma brucei pyruvate kinase 1, putative 0.0031 0.0068 0.0156
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.0633 0.0621
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0073 0.0403 0.039
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0389 0.2922 1
Schistosoma mansoni caspase-3 (C14 family) 0.0091 0.0548 0.0536
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0047 0.0196 0.0183
Loa Loa (eye worm) hypothetical protein 0.0137 0.0913 0.0901
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0034 0.0096
Schistosoma mansoni calpain C (C02 family) 0.0044 0.0176 0.0163
Loa Loa (eye worm) hypothetical protein 0.005 0.0221 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0389 0.2922 0.2913
Entamoeba histolytica cysteine protease, putative 0.0389 0.2922 1
Schistosoma mansoni caspase-7 (C14 family) 0.0091 0.0548 0.0536
Loa Loa (eye worm) hypothetical protein 0.0389 0.2922 0.2913
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0633 0.1763
Schistosoma mansoni cathepsin B (C01 family) 0.0101 0.0633 0.0621
Onchocerca volvulus 0.0101 0.0633 0.2131
Leishmania major eukaryotic initiation factor 4a, putative 0.021 0.1498 0.4222
Loa Loa (eye worm) hypothetical protein 0.0471 0.3577 0.3568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0272 0.1994 0.5633
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.021 0.1498 0.5104
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0047 0.0196 0.0521
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0633 0.0621
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0027 0.0039 0.4717
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.003 0.0064 0.0051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0024 0.0019 0.0015
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.021 0.1498 0.4222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0389 0.2922 0.8272
Plasmodium vivax unspecified product 0.0101 0.0633 0.2156
Schistosoma mansoni cathepsin F (C01 family) 0.0389 0.2922 0.2913
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0099 0.0617 0.0604
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.021 0.1498 0.4222
Brugia malayi cathepsin L-like cysteine proteinase 0.0101 0.0633 0.0621
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0465 0.353 0.3522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0267 0.1954 0.5517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.2922 0.8272
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0617 0.1716
Echinococcus multilocularis Mastin 0.0068 0.0368 0.0355
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0044 0.0173 0.0548
Echinococcus granulosus cathepsin l cysteine peptidase 0.0389 0.2922 0.2913
Trypanosoma cruzi pyruvate kinase 2, putative 0.0031 0.0068 0.0055
Entamoeba histolytica cysteine protease, putative 0.0218 0.1561 0.5321
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0172 0.1194 0.1182
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.0617 0.2075
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.0617 0.1716
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0073 0.0403 0.1108
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0368 0.0355
Giardia lamblia Cathepsin L precursor 0.0101 0.0633 0.1763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.1561 0.4401
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0163
Echinococcus multilocularis calpain 0.0044 0.0176 0.0163
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0101 0.0633 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0389 0.2922 0.8272
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0101 0.0633 0.2131
Brugia malayi hypothetical protein 0.0068 0.0368 0.0355
Onchocerca volvulus 0.0066 0.035 0.1157
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.021 0.1498 0.4222
Schistosoma mansoni cathepsin F (C01 family) 0.0272 0.1994 0.1984
Brugia malayi Cathepsin L-like precursor 0.0389 0.2922 0.2913
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0039 0.0074
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0176 0.0163
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0073 0.0403 0.1339
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0218 0.1561 0.155
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0176 0.0462
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0272 0.1994 0.1984
Echinococcus granulosus glycoprotein Antigen 5 0.0068 0.0368 0.0355
Echinococcus multilocularis calpain family protein 1, d 0.0086 0.0509 0.0496
Brugia malayi Cathepsin L-like precursor 0.0272 0.1994 0.1984
Echinococcus multilocularis eukaryotic initiation factor 4A 0.021 0.1498 0.1487
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0101 0.0633 0.0621
Brugia malayi Papain family cysteine protease containing protein 0.0218 0.1561 0.155

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) uM Binding affinity of the compound against Thrombin; Not available ChEMBL. 11266180
Ki (binding) 0 uM Binding affinity of the compound against Thrombin; Not available ChEMBL. 11266180
Ki (binding) = 0.145 uM Binding affinity against human coagulation factor Xa ChEMBL. 11266180
Ki (binding) = 0.145 uM Binding affinity against human coagulation factor Xa ChEMBL. 11266180
Ki (binding) = 2.2 uM Binding affinity against human trypsin ChEMBL. 11266180
Ki (binding) = 2.2 uM Binding affinity against human trypsin ChEMBL. 11266180

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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