Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0468 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.0759 | 0.3255 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.3452 | 0.5353 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0974 | 0.2817 | 0.7959 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0038 | 0.0017 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1466 | 0.4288 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1186 | 0.3452 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | matrixin family protein | 0.2188 | 0.645 | 1 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0544 | 0.1531 | 0.4001 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.105 | 0.1035 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0087 | 0.0163 | 0.0415 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0791 | 0.2268 | 1 |
Brugia malayi | Matrixin family protein | 0.2188 | 0.645 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0544 | 0.1531 | 0.3806 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0108 | 0.0226 | 0.035 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.0759 | 0.1177 |
Mycobacterium ulcerans | hydrolase | 0.1186 | 0.3452 | 0.8036 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0116 | 0.0249 | 0.0387 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.0555 | 0.086 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1826 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0202 | 0.0525 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0133 | 0.0302 | 0.0468 |
Onchocerca volvulus | Matrilysin homolog | 0.0974 | 0.2817 | 0.4278 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0181 | 0.0445 | 0.0689 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0791 | 0.2268 | 0.6183 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.035 | 0.0749 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0791 | 0.2268 | 0.3488 |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.1165 | 0.115 |
Brugia malayi | Hemopexin family protein | 0.1214 | 0.3535 | 0.5481 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | matrixin family protein | 0.216 | 0.6367 | 0.9871 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.0759 | 0.1177 |
Onchocerca volvulus | 0.0248 | 0.0645 | 0.0777 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1695 | 0.4974 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0974 | 0.2817 | 0.4368 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.0555 | 0.086 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0202 | 0.669 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.6737 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.0645 | 0.2743 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.0272 | 0.0725 |
Onchocerca volvulus | 0.1214 | 0.3535 | 0.5436 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0544 | 0.1531 | 0.3522 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0011 | 0.0352 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0246 | 0.064 | 0.122 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Onchocerca volvulus | 0.0974 | 0.2817 | 0.4278 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1186 | 0.3452 | 1 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0011 | 0.0352 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1886 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Brugia malayi | Disintegrin family protein | 0.0038 | 0.0017 | 0.0026 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1695 | 0.4974 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0087 | 0.0163 | 0.0253 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0067 | 0.0102 | 0.0242 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.0759 | 0.211 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3003 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0102 | 0.0158 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1466 | 0.4288 | 0.8349 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.1695 | 0.4974 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8273 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.0759 | 0.1177 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0161 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.2314 | 0.3588 |
Schistosoma mansoni | hypothetical protein | 0.1214 | 0.3535 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0306 | 0.0819 | 0.5 |
Echinococcus multilocularis | adam | 0.0067 | 0.0102 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0017 | 0.0026 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0791 | 0.2268 | 0.5255 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0116 | 0.0249 | 0.0661 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8217 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0181 | 0.0445 | 0.1215 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.035 | 0.0314 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.105 | 0.2937 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1186 | 0.3452 | 0.5353 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0474 | 0.1319 | 0.3702 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3375 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0809 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.216 | 0.6367 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0311 | 0.0834 | 0.1561 |
Onchocerca volvulus | Matrilysin homolog | 0.216 | 0.6367 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0163 | 0.0253 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus granulosus | adam | 0.0067 | 0.0102 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.0759 | 0.171 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 560 uM | Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1995896 |
CC50 (functional) | = 560 uM | Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1995896 |
IC50 (functional) | = 35 uM | Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1. | ChEMBL. | 1995896 |
Selectivity index (functional) | = 16 | Selectivity index measured as the ratio of CC50/IC50 values. | ChEMBL. | 1995896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.