Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0613 | 0.1485 |
Trichomonas vaginalis | conserved hypothetical protein | 0.036 | 0.5573 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.014 | 0.1875 | 0.0502 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0223 | 0.3272 | 0.409 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0624 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.1466 | 0.3617 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.2949 | 0.7321 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.047 | 0.3208 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0613 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0354 | 0.5461 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.106 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.3422 | 0.5995 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.4022 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0894 | 0.605 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0038 | 0.0051 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0622 | 0.9962 | 0.9933 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0354 | 0.5461 | 0.9714 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0354 | 0.5461 | 0.5388 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0894 | 0.2188 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.014 | 0.1875 | 0.2814 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0094 | 0.0969 |
Schistosoma mansoni | glutaminase | 0.0268 | 0.4022 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.0949 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0202 | 0.1273 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.047 | 0.113 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0613 | 0.4105 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.4022 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Onchocerca volvulus | 0.0081 | 0.0894 | 0.2574 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0241 | 0.357 | 0.4857 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0018 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.047 | 0.113 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0613 | 0.4178 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.047 | 0.0275 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0128 | 0.1679 | 0.1513 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0613 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0624 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 0.4022 | 0.7113 |
Onchocerca volvulus | 0.0232 | 0.3422 | 1 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.036 | 0.5573 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0894 | 0.6098 |
Brugia malayi | polk-prov protein | 0.003 | 0.0038 | 0.0051 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0094 | 0.0969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0883 | 0.216 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.036 | 0.5573 | 0.2188 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0241 | 0.357 | 0.6211 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0622 | 0.9962 | 1 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0119 | 0.153 | 0.2122 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0286 | 0.4333 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.014 | 0.1875 | 0.1714 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0613 | 0.1485 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.1466 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0128 | 0.1679 | 0.2422 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0407 | 0.0971 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 0.4022 | 0.3914 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.4022 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.1466 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.036 | 0.5573 | 0.5502 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.047 | 0.3124 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.4333 | 0.7691 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0202 | 0.138 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0613 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0613 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0613 | 0.1485 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.047 | 0.0275 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.2949 | 0.7321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0223 | 0.3272 | 0.5612 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0241 | 0.357 | 0.3451 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0018 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.015 ug ml-1 | In vitro anti-picornavirus activity against Rhinovirus type-2. | ChEMBL. | 2989517 |
MIC (functional) | = 0.6 ug ml-1 | Compound tested in vitro for anti-picornavirus activity against Poliovirus type-2 | ChEMBL. | 2989517 |
MTL (functional) | = 12.5 ug ml-1 | Maximum testable level of compound was evaluated | ChEMBL. | 2989517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.