Detailed information for compound 282074

Basic information

Technical information
  • TDR Targets ID: 282074
  • Name: 4-[2-[butyl(propyl)amino]ethyl]benzene-1,2-di ol
  • MW: 251.364 | Formula: C15H25NO2
  • H donors: 2 H acceptors: 2 LogP: 3.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCc1ccc(c(c1)O)O)CCC
  • InChi: 1S/C15H25NO2/c1-3-5-10-16(9-4-2)11-8-13-6-7-14(17)15(18)12-13/h6-7,12,17-18H,3-5,8-11H2,1-2H3
  • InChiKey: RGTAZIDCEVLAOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[butyl(propyl)amino]ethyl]pyrocatechol
  • N-n-propyl-N-n-butyl-beta-dopamine
  • 4-[2-(butyl-propylamino)ethyl]benzene-1,2-diol
  • 4-[2-(butyl-propyl-amino)ethyl]benzene-1,2-diol
  • 4-[2-(butyl-propyl-amino)ethyl]pyrocatechol
  • 1,2-Benzenediol, 4-(2-(butylpropylamino)ethyl)-
  • N-Pbda
  • N-n-Propyl-N-n-butyl-beta-(3,4-dihydroxyphenyl)ethylamine
  • Propylbutyldopamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin l1 0.0526 0.5962 0.5897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.1094 0.2534
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Toxoplasma gondii cathepsin CPC1 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Giardia lamblia Hypothetical protein 0.0116 0.1094 0.2534
Plasmodium falciparum serine repeat antigen 3 0.0116 0.1094 0.1611
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Giardia lamblia Cathepsin B precursor 0.0116 0.1094 0.2534
Echinococcus multilocularis cathepsin L 0.0282 0.3067 0.2956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0116 0.1094 0.1094
Schistosoma mansoni cathepsin S (C01 family) 0.0116 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0277 0.0277
Loa Loa (eye worm) fibroinase 0.0526 0.5962 0.5962
Brugia malayi cathepsin L precursor 0.0116 0.1094 0.1094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0866 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.1094 0.1611
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Echinococcus granulosus cathepsin b 0.0866 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0116 0.1094 0.1611
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0116 0.1094 0.1094
Echinococcus multilocularis cysteine protease 0.0526 0.5962 0.5897
Plasmodium vivax unspecified product 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Schistosoma mansoni histone deacetylase 4 5 0.0037 0.0158 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0526 0.5962 1
Brugia malayi histone deacetylase 11 0.0037 0.0158 0.0158
Plasmodium vivax serine-repeat antigen (SERA) 0.0116 0.1094 0.1611
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0116 0.1094 0.1094
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0526 0.5962 0.5962
Giardia lamblia Cathepsin B precursor 0.0116 0.1094 0.2534
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0277 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Schistosoma mansoni cathepsin B (C01 family) 0.0116 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.036 0.3989 0.6599
Loa Loa (eye worm) hypothetical protein 0.0866 1 1
Brugia malayi hypothetical protein 0.0047 0.0277 0.0277
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Plasmodium vivax unspecified product 0.0166 0.169 0.2639
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0277 0.0121
Trypanosoma cruzi cruzipain precursor, putative 0.0166 0.169 0.1556
Giardia lamblia Cathepsin L-like protease 0.0116 0.1094 0.2534
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0116 0.1094 0.1611
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0526 0.5962 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0348 0.3848 0.6357
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0205
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Loa Loa (eye worm) norepinephrine transporter 0.0278 0.3021 0.3021
Onchocerca volvulus 0.0047 0.0277 0.0205
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0526 0.5962 0.5897
Schistosoma mansoni cathepsin C 0.0116 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0277 0.0205
Giardia lamblia Cathepsin L-like protease 0.0116 0.1094 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1094 0.1611
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Brugia malayi histone deacetylase 3 (HD3) 0.0037 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0158
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.1094 0.1611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0278 0.3021 0.3021
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0116 0.1094 0.1611
Plasmodium falciparum serine repeat antigen 9 0.0116 0.1094 0.1611
Schistosoma mansoni histone deacetylase 4 5 0.0037 0.0158 0.0158
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.1094 0.2534
Brugia malayi Histone deacetylase family protein 0.0037 0.0158 0.0158
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0116 0.1094 0.1611
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0278 0.3021 0.3021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.1094 0.1611
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0116 0.1094 0.1611
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0116 0.1094 0.1094
Loa Loa (eye worm) serotonin transporter b 0.0278 0.3021 0.3021
Onchocerca volvulus 0.0526 0.5962 1
Toxoplasma gondii cathepsin CPC2 0.0116 0.1094 0.1611
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0116 0.1094 0.1611
Echinococcus granulosus cathepsin b 0.0866 1 1
Giardia lamblia Encystation-specific protease 0.0116 0.1094 0.2534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Toxoplasma gondii cathepsin B 0.0348 0.3848 0.6357
Plasmodium vivax amine transporter, putative 0.0047 0.0277 0.0205
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0277 0.0121
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0116 0.1094 0.1094
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.1094 0.1094
Echinococcus granulosus serotonin transporter 0.0278 0.3021 0.2909
Onchocerca volvulus 0.0526 0.5962 1
Toxoplasma gondii hypothetical protein 0.0047 0.0277 0.0205
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0277 0.0121
Schistosoma mansoni cathepsin F (C01 family) 0.0526 0.5962 0.5962
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0866 1 1
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Loa Loa (eye worm) histone deacetylase 1 0.0037 0.0158 0.0158
Brugia malayi Histone deacetylase 1 0.0037 0.0158 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0116 0.1094 0.1611
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0277 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3067 0.5012
Giardia lamblia Cathepsin B precursor 0.0348 0.3848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0277 0.0277
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Loa Loa (eye worm) histone deacetylase 3 0.0037 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0116 0.1094 0.1611
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.1094 0.1611
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.3067 0.5012
Loa Loa (eye worm) hypothetical protein 0.036 0.3989 0.3989
Trypanosoma cruzi cysteine peptidase, putative 0.0526 0.5962 0.5897
Schistosoma mansoni histone deacetylase 0.0037 0.0158 0.0158
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0131 0.0131
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Schistosoma mansoni sodium/chloride dependent transporter 0.0278 0.3021 0.3021
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Brugia malayi Cathepsin L-like precursor 0.036 0.3989 0.3989
Echinococcus multilocularis serotonin transporter 0.0278 0.3021 0.2909
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0116 0.1094 0.1094
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.036 0.3989 0.3892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0205
Plasmodium falciparum serine repeat antigen 7 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0348 0.3848 0.6357
Loa Loa (eye worm) hypothetical protein 0.036 0.3989 0.3989
Plasmodium falciparum cysteine proteinase falcipain 1 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.3067 0.5012
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0116 0.1094 0.1611
Plasmodium vivax serine-repeat antigen (SERA) 0.0116 0.1094 0.1611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0277
Brugia malayi fibroinase precursor 0.0116 0.1094 0.1094
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.3067 0.2956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Plasmodium vivax vivapain-2 0.0526 0.5962 1
Trypanosoma cruzi cysteine proteinase, putative 0.0282 0.3067 0.2956
Entamoeba histolytica hypothetical protein 0.0116 0.1094 0.1611
Plasmodium vivax vivapain-2 0.0526 0.5962 1
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Plasmodium falciparum serine repeat antigen 4 0.0116 0.1094 0.1611
Trypanosoma brucei cysteine peptidase C (CPC) 0.0348 0.3848 0.6357
Echinococcus granulosus cathepsin l1 0.036 0.3989 0.3892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Entamoeba histolytica cysteine proteinase, putative 0.0526 0.5962 1
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0116 0.1094 0.1611
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0866 1 1
Onchocerca volvulus 0.0526 0.5962 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0116 0.1094 0.1611
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0116 0.1094 0.1611
Loa Loa (eye worm) cysteine protease 0.0526 0.5962 0.5962
Echinococcus granulosus cathepsin L 0.0282 0.3067 0.2956
Echinococcus multilocularis cathepsin b 0.0866 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0116 0.1094 0.1611
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Plasmodium vivax vivapain-3 0.0282 0.3067 0.5012
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0116 0.1094 0.1611
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0116 0.1094 0.2534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Brugia malayi Cathepsin L-like precursor 0.0166 0.169 0.169
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine proteinase, putative 0.0526 0.5962 1
Brugia malayi Papain family cysteine protease containing protein 0.0526 0.5962 0.5962
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0526 0.5962 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0037 0.0158 0.0158
Schistosoma mansoni histone deacetylase hda2 0.0037 0.0158 0.0158
Trypanosoma cruzi major cysteine proteinase, putative 0.0116 0.1094 0.095
Brugia malayi cathepsin Z-like cysteine proteinase 0.0116 0.1094 0.1094
Echinococcus granulosus cathepsin l cysteine peptidase 0.0526 0.5962 0.5897
Loa Loa (eye worm) hypothetical protein 0.036 0.3989 0.3989
Giardia lamblia Cathepsin B precursor 0.0348 0.3848 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0277 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1094 0.1611
Plasmodium vivax unspecified product 0.0282 0.3067 0.5012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0348 0.3848 0.3749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.1094 0.1611
Onchocerca volvulus Cathepsin L homolog 0.0526 0.5962 1
Giardia lamblia Cathepsin B precursor 0.0116 0.1094 0.2534
Trypanosoma cruzi cysteine protease, putative 0.0282 0.3067 0.2956
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0526 0.5962 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0166 0.169 0.169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Onchocerca volvulus 0.0047 0.0277 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Onchocerca volvulus 0.0047 0.0277 0.0205
Giardia lamblia Cysteine protease 0.0116 0.1094 0.2534
Plasmodium falciparum transporter, putative 0.0047 0.0277 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.0526 0.5962 0.5897
Brugia malayi cathepsin L-like cysteine proteinase 0.0116 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0278 0.3021 0.3021
Toxoplasma gondii cathepsin CPL 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0526 0.5962 0.5962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.1094 0.1094
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0131
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0277 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Loa Loa (eye worm) hypothetical protein 0.0278 0.3021 0.3021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0282 0.3067 0.3067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.169 0.169
Plasmodium falciparum serine repeat antigen 1 0.0116 0.1094 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0282 0.3067 0.5012
Toxoplasma gondii hypothetical protein 0.0047 0.0277 0.0205
Schistosoma mansoni cathepsin F (C01 family) 0.0526 0.5962 0.5962
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0277 0.0277
Onchocerca volvulus 0.0526 0.5962 1
Onchocerca volvulus 0.0116 0.1094 0.1611
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.1094 0.2534
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0131 0.0131
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0277
Echinococcus multilocularis cysteine protease 0.0526 0.5962 0.5897
Loa Loa (eye worm) hypothetical protein 0.0526 0.5962 0.5962
Trypanosoma cruzi cysteine peptidase, putative 0.0526 0.5962 0.5897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0348 0.3848 0.3848
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0282 0.3067 0.2956
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Schistosoma mansoni cathepsin s 0.0166 0.169 0.169
Schistosoma mansoni histone deacetylase hda2 0.0037 0.0158 0.0158
Echinococcus granulosus cathepsin L cysteine proteinase 0.0526 0.5962 0.5897
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Plasmodium falciparum serine repeat antigen 8 0.0116 0.1094 0.1611
Giardia lamblia Cysteine protease 0.0116 0.1094 0.2534
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0277 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.1094 0.1611
Onchocerca volvulus 0.0278 0.3021 0.4933
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.3067 0.5012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0116 0.1094 0.1611
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0277 0.5
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0277 0.0121
Brugia malayi Cathepsin L-like cysteine proteinase 0.036 0.3989 0.3989
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Loa Loa (eye worm) histone deacetylase 0.0037 0.0158 0.0158
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0282 0.3067 0.3067
Giardia lamblia Cathepsin B precursor 0.0116 0.1094 0.2534
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0277
Loa Loa (eye worm) histone deacetylase 11 0.0037 0.0158 0.0158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0866 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0526 0.5962 0.5897
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0116 0.1094 0.1611
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0282 0.3067 0.3067
Loa Loa (eye worm) hypothetical protein 0.0166 0.169 0.169
Brugia malayi cathepsin L-like precursor 0.036 0.3989 0.3989
Schistosoma mansoni histone deacetylase 0.0037 0.0158 0.0158
Onchocerca volvulus Cathepsin F homolog 0.0526 0.5962 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0278 0.3021 0.3021
Trypanosoma cruzi cruzipain precursor, putative 0.0526 0.5962 0.5897
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Echinococcus granulosus cathepsin L 0.0116 0.1094 0.095
Brugia malayi Cathepsin L-like precursor 0.0526 0.5962 0.5962
Entamoeba histolytica cysteine proteinase, putative 0.036 0.3989 0.6599
Echinococcus granulosus cathepsin L cysteine protease 0.0282 0.3067 0.2956
Trypanosoma cruzi major cysteine proteinase, putative 0.0116 0.1094 0.095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0526 0.5962 1
Plasmodium vivax vivapain-1 0.0282 0.3067 0.5012
Loa Loa (eye worm) ctsf protein 0.0526 0.5962 0.5962
Trypanosoma cruzi cysteine peptidase, putative 0.0526 0.5962 0.5897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Giardia lamblia Hypothetical protein 0.0116 0.1094 0.2534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.036 0.3989 0.6599
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0131 0.0131
Trypanosoma cruzi cysteine proteinase, putative 0.0282 0.3067 0.2956
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.1094 0.1094
Brugia malayi Cathepsin L-like precursor 0.036 0.3989 0.3989
Echinococcus multilocularis cathepsin L cysteine protease 0.0526 0.5962 0.5897
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0116 0.1094 0.1611
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0116 0.1094 0.1611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Loa Loa (eye worm) cathepsin B 0.0348 0.3848 0.3848
Trypanosoma cruzi cysteine peptidase, putative 0.0166 0.169 0.1556
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0277 0.0121
Entamoeba histolytica cysteine proteinase 2 0.0282 0.3067 0.5012
Brugia malayi Histone deacetylase family protein 0.0037 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.1094 0.1611
Leishmania major cathepsin L-like protease 0.0526 0.5962 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.3021 0.3021
Schistosoma mansoni cathepsin F (C01 family) 0.036 0.3989 0.3989
Giardia lamblia Cysteine protease 0.0116 0.1094 0.2534
Entamoeba histolytica cysteine protease, putative 0.0526 0.5962 1
Leishmania major cysteine peptidase A (CPA) 0.0526 0.5962 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0277 0.0121
Echinococcus granulosus cysteine protease 0.0282 0.3067 0.2956
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0116 0.1094 0.1094
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0526 0.5962 0.5897
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0166 0.169 0.169
Onchocerca volvulus 0.036 0.3989 0.6599
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0526 0.5962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Plasmodium falciparum serine repeat antigen 6 0.0116 0.1094 0.1611
Giardia lamblia Cysteine protease 0.0116 0.1094 0.2534
Loa Loa (eye worm) hypothetical protein 0.0166 0.169 0.169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0526 0.5962 1
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.3067 0.3067
Echinococcus multilocularis cathepsin L 0.0116 0.1094 0.095
Echinococcus multilocularis cathepsin b 0.0866 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.1094 0.1094
Plasmodium falciparum serine repeat antigen 2 0.0116 0.1094 0.1611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0526 0.5962 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0116 0.1094 0.1094
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0116 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0166 0.169 0.169
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0277 0.0277
Giardia lamblia Cathepsin B precursor 0.0348 0.3848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Brugia malayi histone deacetylase 1 (HD1) 0.0037 0.0158 0.0158
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0205
Onchocerca volvulus 0.0526 0.5962 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0116 0.1094 0.1611
Plasmodium falciparum serine repeat antigen 5 0.0116 0.1094 0.1611
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.1094 0.1094
Entamoeba histolytica cysteine protease, putative 0.0282 0.3067 0.5012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.1094 0.1094
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0277 0.0121
Brugia malayi cathepsin F-like cysteine proteinase 0.0116 0.1094 0.1094
Treponema pallidum sodium- and chloride- dependent transporter 0.0278 0.3021 0.5
Loa Loa (eye worm) histone deacetylase 7A 0.0037 0.0158 0.0158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0866 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0116 0.1094 0.1094
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0277 0.0277
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0277 0.0277
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.3067 0.3067
Onchocerca volvulus 0.0526 0.5962 1
Giardia lamblia Cathepsin B precursor 0.0116 0.1094 0.2534
Toxoplasma gondii preprocathepsin c precursor, putative 0.0116 0.1094 0.1611
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1094 0.1611
Onchocerca volvulus 0.0526 0.5962 1
Entamoeba histolytica cysteine protease, putative 0.0116 0.1094 0.1611
Giardia lamblia Cathepsin L precursor 0.0116 0.1094 0.2534
Leishmania major cathepsin L-like protease 0.0526 0.5962 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 48 nM Inhibition of the constrictor response to electrical stimulation in rabbit ear artery. ChEMBL. 2871192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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