Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1214 | 0.3535 | 0.5436 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0011 | 0.0352 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0544 | 0.1531 | 0.3522 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.0272 | 0.0725 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.0645 | 0.2743 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0202 | 0.669 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.6737 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0974 | 0.2817 | 0.4368 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1695 | 0.4974 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.0555 | 0.086 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | matrixin family protein | 0.216 | 0.6367 | 0.9871 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.0759 | 0.1177 |
Onchocerca volvulus | 0.0248 | 0.0645 | 0.0777 | |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.1165 | 0.115 |
Brugia malayi | Hemopexin family protein | 0.1214 | 0.3535 | 0.5481 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1826 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0202 | 0.0525 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0181 | 0.0445 | 0.0689 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0133 | 0.0302 | 0.0468 |
Onchocerca volvulus | Matrilysin homolog | 0.0974 | 0.2817 | 0.4278 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.035 | 0.0749 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0791 | 0.2268 | 0.6183 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0791 | 0.2268 | 0.3488 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.0759 | 0.1177 |
Mycobacterium ulcerans | hydrolase | 0.1186 | 0.3452 | 0.8036 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.0555 | 0.086 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0116 | 0.0249 | 0.0387 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0544 | 0.1531 | 0.3806 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0108 | 0.0226 | 0.035 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0791 | 0.2268 | 1 |
Brugia malayi | Matrixin family protein | 0.2188 | 0.645 | 1 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0544 | 0.1531 | 0.4001 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0087 | 0.0163 | 0.0415 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.105 | 0.1035 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1466 | 0.4288 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1186 | 0.3452 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | matrixin family protein | 0.2188 | 0.645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0468 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.0759 | 0.3255 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0974 | 0.2817 | 0.7959 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.3452 | 0.5353 |
Loa Loa (eye worm) | reprolysin | 0.0038 | 0.0017 | 0.0026 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.0759 | 0.171 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus granulosus | adam | 0.0067 | 0.0102 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0311 | 0.0834 | 0.1561 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.216 | 0.6367 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Onchocerca volvulus | Matrilysin homolog | 0.216 | 0.6367 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0163 | 0.0253 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3375 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0809 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0181 | 0.0445 | 0.1215 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.035 | 0.0314 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.105 | 0.2937 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1186 | 0.3452 | 0.5353 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0474 | 0.1319 | 0.3702 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0791 | 0.2268 | 0.5255 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0116 | 0.0249 | 0.0661 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8217 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0306 | 0.0819 | 0.5 |
Echinococcus multilocularis | adam | 0.0067 | 0.0102 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0017 | 0.0026 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0161 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.2314 | 0.3588 |
Schistosoma mansoni | hypothetical protein | 0.1214 | 0.3535 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.1695 | 0.4974 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8273 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.0759 | 0.1177 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0102 | 0.0158 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1466 | 0.4288 | 0.8349 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.0759 | 0.211 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3003 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Brugia malayi | Disintegrin family protein | 0.0038 | 0.0017 | 0.0026 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1695 | 0.4974 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0087 | 0.0163 | 0.0253 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0067 | 0.0102 | 0.0242 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0011 | 0.0352 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1886 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0246 | 0.064 | 0.122 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Onchocerca volvulus | 0.0974 | 0.2817 | 0.4278 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1186 | 0.3452 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 443 uM | Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1995896 |
CC50 (functional) | = 443 uM | Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1995896 |
IC50 (functional) | = 58 uM | Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1. | ChEMBL. | 1995896 |
Selectivity index (functional) | = 8 | Selectivity index measured as the ratio of CC50/IC50 values. | ChEMBL. | 1995896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.