Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.022 | 0.3272 | 0.409 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0138 | 0.1875 | 0.0502 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.5573 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.0613 | 0.1485 |
Loa Loa (eye worm) | glutaminase | 0.0264 | 0.4022 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3422 | 0.5995 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.106 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0349 | 0.5461 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 0.047 | 0.3208 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2949 | 0.7321 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.1466 | 0.3617 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0616 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0138 | 0.1875 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0894 | 0.2188 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0349 | 0.5461 | 0.5388 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0349 | 0.5461 | 0.9714 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0038 | 0.0051 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0614 | 0.9962 | 0.9933 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.008 | 0.0894 | 0.605 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0123 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0238 | 0.357 | 0.4857 |
Onchocerca volvulus | 0.008 | 0.0894 | 0.2574 | |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 0.4105 |
Loa Loa (eye worm) | glutaminase 2 | 0.0264 | 0.4022 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.0949 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0202 | 0.1273 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0055 | 0.047 | 0.113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.0094 | 0.0969 |
Schistosoma mansoni | glutaminase | 0.0264 | 0.4022 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.008 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0127 | 0.1679 | 0.1513 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0055 | 0.047 | 0.0275 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 0.4178 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.047 | 0.113 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0018 | 0.5 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0614 | 0.9962 | 1 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0118 | 0.153 | 0.2122 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.0883 | 0.216 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0355 | 0.5573 | 0.2188 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0238 | 0.357 | 0.6211 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Trypanosoma brucei | unspecified product | 0.0033 | 0.0094 | 0.0969 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trichomonas vaginalis | glutaminase, putative | 0.0264 | 0.4022 | 0.7113 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.008 | 0.0894 | 0.6098 |
Brugia malayi | polk-prov protein | 0.003 | 0.0038 | 0.0051 |
Onchocerca volvulus | 0.0229 | 0.3422 | 1 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0355 | 0.5573 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0616 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0355 | 0.5573 | 0.5502 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0055 | 0.047 | 0.3124 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.1466 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0127 | 0.1679 | 0.2422 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0407 | 0.0971 |
Mycobacterium ulcerans | glutaminase | 0.0264 | 0.4022 | 0.3914 |
Brugia malayi | glutaminase DH11.1 | 0.0264 | 0.4022 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0613 | 0.1485 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.1466 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0138 | 0.1875 | 0.1714 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0283 | 0.4333 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0238 | 0.357 | 0.3451 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0018 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.008 | 0.0894 | 0.2188 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2949 | 0.7321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.022 | 0.3272 | 0.5612 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0055 | 0.047 | 0.0275 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0613 | 0.1485 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0283 | 0.4333 | 0.7691 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0202 | 0.138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0 | The compound was modelled in silico for carcinogenic potency; + = Carcinogen | ChEMBL. | 7108894 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.