Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | ND 0 % | The initial growth rate of cells in the presence of the compound at the screen concentration 10 mM in human epidermoid carcinoma cells (H.Ep.2); Not done | ChEMBL. | 9057863 |
Control (functional) | = 93 % | The initial growth rate of cells in the presence of the compound at the screen concentration 10 mM in leukemic cells (L1210) of mice | ChEMBL. | 9057863 |
Control (functional) | = 93 % | The initial growth rate of cells in the presence of the compound at the screen concentration 10 mM in leukemic cells (L1210) of mice | ChEMBL. | 9057863 |
IC50 (functional) | e 0 mM | Concentration of the compound required to decrease the growth rate to 50% of control; cell proliferation was not slowed down at screen concentration 10 mM | ChEMBL. | 9057863 |
IC50 (functional) | e 0 mM | The concentration of the compound required to decrease the estimate of the minimum fraction of leukemic cells (L1210) of mice that survived treatment to 50%. * indicates cell proliferation was not slowed down at screen concentration 10 mM | ChEMBL. | 9057863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.