Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | = 22 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 22 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 24 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 24 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 24 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 24 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
IC50 (functional) | = 1.1 uM | Concentration required to cause 50% relaxation of maximal contraction in circumferential rabbit aorta strips in response to KCl (100 mM) | ChEMBL. | 1311765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.