Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0622 | 1 | 1 |
Onchocerca volvulus | 0.0231 | 0.3422 | 1 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0359 | 0.5573 | 1 |
Brugia malayi | polk-prov protein | 0.003 | 0.0038 | 0.0051 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0894 | 0.6098 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.4022 | 0.7113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.024 | 0.357 | 0.6211 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0359 | 0.5573 | 0.2188 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0883 | 0.216 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0119 | 0.153 | 0.2122 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.062 | 0.9962 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0094 | 0.0969 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0018 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 0.4178 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.047 | 0.113 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.047 | 0.0275 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0128 | 0.1679 | 0.1513 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0613 | 0.1485 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.047 | 0.0275 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0202 | 0.138 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0894 | 0.2188 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.024 | 0.357 | 0.3451 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0018 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0202 | 0.2858 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0222 | 0.3272 | 0.5612 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.2949 | 0.7321 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0139 | 0.1875 | 0.1714 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.1466 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0613 | 0.1485 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0285 | 0.4333 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.1466 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.047 | 0.3124 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0359 | 0.5573 | 0.5502 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.4022 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.4022 | 0.3914 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0407 | 0.0971 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0128 | 0.1679 | 0.2422 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.2949 | 0.7321 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0613 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.047 | 0.3208 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0622 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.1466 | 0.3617 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.3422 | 0.5995 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.4022 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0352 | 0.5461 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.106 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0359 | 0.5573 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.0613 | 0.1485 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.1875 | 0.0502 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0222 | 0.3272 | 0.409 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.047 | 0.113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0155 | 0.0949 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0202 | 0.1273 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.4022 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0613 | 0.4105 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.4022 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0094 | 0.0969 |
Onchocerca volvulus | 0.0081 | 0.0894 | 0.2574 | |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.024 | 0.357 | 0.4857 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0352 | 0.5461 | 0.9714 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0352 | 0.5461 | 0.5388 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.4333 | 0.7691 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0123 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0894 | 0.605 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0202 | 0.2858 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.062 | 0.9962 | 0.9933 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0038 | 0.0051 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0139 | 0.1875 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0894 | 0.2188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 13 % | Inhibition of passive cutaneous anaphylaxis following 10 mg/kg p.o. administration. | ChEMBL. | 6229634 |
Inhibition (functional) | = 18 % | Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration. | ChEMBL. | 6229634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.