Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0031 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0031 | 0.5 | 0.5 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0031 | 0.5 | 0.5 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0031 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0031 | 0.5 | 0.5 |
Mycobacterium ulcerans | lipoprotein LppD | 0.0031 | 0.5 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.5 | 0.5 |
Giardia lamblia | Protein LRP16 | 0.0031 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0031 | 0.5 | 0.5 |
Toxoplasma gondii | macro domain-containing protein | 0.0031 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.5 | 0.5 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0031 | 0.5 | 0.5 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0031 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16000 nM | In vitro inhibitory activity against human neutrophil elastase (HNE-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala- Ala-Pro-Val-pN) | ChEMBL. | 7837243 |
Ki (binding) | = 16000 nM | In vitro inhibitory activity against human neutrophil elastase (HNE-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala- Ala-Pro-Val-pN) | ChEMBL. | 7837243 |
Ki (binding) | = 16000 nM | Inhibition of human neutrophil elastase | ChEMBL. | 21413808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.