Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0483 | 0.7036 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Toxoplasma gondii | MAPEG family protein | 0.0548 | 0.8039 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0483 | 0.7036 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0077 | 0.0747 | 0.5 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0483 | 0.7036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0548 | 0.8039 | 0.788 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0548 | 0.8039 | 0.788 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.0483 | 0.7036 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0675 | 1 | 1 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0548 | 0.8039 | 0.788 |
Brugia malayi | Doublecortin family protein | 0.0077 | 0.0747 | 0.0747 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0675 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0.0747 | 0.5 | |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0483 | 0.7036 | 0.5 |
Onchocerca volvulus | 0.0077 | 0.0747 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0675 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0077 | 0.0747 | 0.0747 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0747 | 0.0747 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0548 | 0.8039 | 0.788 |
Schistosoma mansoni | lipoxygenase | 0.0324 | 0.4566 | 0.4127 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0483 | 0.7036 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0675 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0463 | 0.6727 | 0.6462 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0077 | 0.0747 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PCA shift (functional) | = 3 | Antiallergic activity against IgE-mediated passive cutaneous anaphylaxis (PCA) in rats | ChEMBL. | 6180166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.