Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2567 | 0.2567 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.024 | 0.4405 | 0.4405 |
Plasmodium vivax | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Giardia lamblia | Histone deacetylase | 0.0413 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0269 | 0.5331 | 0.4392 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0446 | 0.0446 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0184 | 0.2567 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0269 | 0.5331 | 0.3719 |
Loa Loa (eye worm) | histone deacetylase | 0.0269 | 0.5331 | 0.5331 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0413 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0288 | 0.5937 | 0.512 |
Echinococcus multilocularis | histone deacetylase | 0.0269 | 0.5331 | 0.5087 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0413 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0184 | 0.2567 | 0.1073 |
Echinococcus granulosus | histone deacetylase 3 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0413 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0413 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0184 | 0.2567 | 0.1073 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0269 | 0.5331 | 0.5087 |
Echinococcus granulosus | histone deacetylase | 0.0269 | 0.5331 | 0.5087 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0269 | 0.5331 | 0.4392 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0184 | 0.2567 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.059 | 0.059 |
Entamoeba histolytica | histone deacetylase, putative | 0.0413 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0269 | 0.5331 | 0.5114 |
Brugia malayi | Histone deacetylase family protein | 0.0269 | 0.5331 | 0.5114 |
Brugia malayi | Histone deacetylase 1 | 0.0413 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0288 | 0.5937 | 0.5724 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0413 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0288 | 0.5937 | 0.5724 |
Mycobacterium leprae | conserved hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0333 | 0.7412 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0269 | 0.5331 | 0.5087 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0184 | 0.2567 | 0.2567 |
Schistosoma mansoni | histone deacetylase | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0269 | 0.5331 | 0.5331 |
Mycobacterium tuberculosis | Conserved protein | 0.0333 | 0.7412 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0413 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0269 | 0.5331 | 0.3719 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0156 | 0.1674 | 0.1286 |
Schistosoma mansoni | histone deacetylase | 0.0413 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0269 | 0.5331 | 0.5087 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0269 | 0.5331 | 0.3719 |
Brugia malayi | histone deacetylase 11 | 0.0184 | 0.2567 | 0.2221 |
Echinococcus granulosus | histone deacetylase 8 | 0.0184 | 0.2567 | 0.2179 |
Trypanosoma brucei | histone deacetylase 1 | 0.0413 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0413 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0269 | 0.5331 | 0.3719 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0413 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0413 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0269 | 0.5331 | 0.3719 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0413 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 5 mg kg-1 | Analgesic activity at 1 min following injection at 1 mg/kg into the lateral tail vein of the rat (55 degree centigrade hot plate assay) | ChEMBL. | 1847432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.