Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | methionyl aminopeptidase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | tyrosyl-tRNA synthetase, putative | 0.0119 | 0.4195 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0.2505 | 0.5972 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Plasmodium falciparum | tRNA import protein tRIP | 0.0093 | 0.2505 | 0.5972 |
Trypanosoma cruzi | tyrosyl-tRNA synthetase, putative | 0.0119 | 0.4195 | 1 |
Schistosoma mansoni | methionyl-tRNA synthetase | 0.0093 | 0.2505 | 0.2505 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0119 | 0.4195 | 1 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0093 | 0.2505 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0.2505 | 0.5972 |
Schistosoma mansoni | tyrosyl-tRNA synthetase | 0.0212 | 1 | 1 |
Trichomonas vaginalis | methionyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Toxoplasma gondii | tRNA synthetases class I family protein | 0.0119 | 0.4195 | 1 |
Leishmania major | tyrosyl or methionyl-tRNA synthetase-like protein | 0.0093 | 0.2505 | 0.5972 |
Echinococcus multilocularis | tyrosyl tRNA synthetase | 0.0212 | 1 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0053 | 0 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0093 | 0.2505 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0093 | 0.2505 | 0.5972 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Plasmodium vivax | methionine-tRNA ligase, putative | 0.0093 | 0.2505 | 0.5972 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Plasmodium vivax | tyrosine--tRNA ligase, putative | 0.0119 | 0.4195 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, beta chain PheT | 0.0093 | 0.2505 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0.2505 | 0.5972 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Leishmania major | hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Echinococcus granulosus | aminoacyl tRNA synthase complex interacting | 0.0093 | 0.2505 | 0.2505 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0093 | 0.2505 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0093 | 0.2505 | 0.5972 |
Echinococcus multilocularis | aminoacyl tRNA synthase complex interacting | 0.0093 | 0.2505 | 0.2505 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Toxoplasma gondii | tRNA binding domain-containing protein | 0.0093 | 0.2505 | 0.5972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Giardia lamblia | Tyrosyl-tRNA synthetase | 0.0119 | 0.4195 | 1 |
Trypanosoma brucei | tyrosyl/methionyl-tRNA synthetase, putative | 0.0093 | 0.2505 | 0.5972 |
Entamoeba histolytica | hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0093 | 0.2505 | 0.5 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0119 | 0.4195 | 1 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit beta | 0.0093 | 0.2505 | 0.5 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit beta | 0.0093 | 0.2505 | 0.5 |
Entamoeba histolytica | tyrosyl-tRNA synthetase, putative | 0.0119 | 0.4195 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Entamoeba histolytica | hypothetical protein | 0.0093 | 0.2505 | 0.5972 |
Plasmodium falciparum | tyrosine--tRNA ligase | 0.0119 | 0.4195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Inhibitory activity against human methionine aminopeptidase-2 | ChEMBL. | 15012983 |
IC50 (binding) | = 0.46 uM | Inhibitory activity against human methionine aminopeptidase-2 | ChEMBL. | 15012983 |
IC50 (binding) | = 101 uM | Inhibitory activity against human methionine aminopeptidase-1 | ChEMBL. | 15012983 |
IC50 (binding) | = 101 uM | Inhibitory activity against human methionine aminopeptidase-1 | ChEMBL. | 15012983 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.