Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0061 | 0.0083 | 0.0054 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.0116 | 0.0116 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0061 | 0.0083 | 0.0083 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0061 | 0.0083 | 0.0054 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2618 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0116 | 0.0116 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0124 | 0.0327 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0064 | 0.0095 | 0.0095 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0077 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0109 | 0.0268 | 0.0268 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0061 | 0.0083 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0491 | 0.0491 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0148 | 0.0419 | 0.0419 |
Plasmodium vivax | plasmepsin IV, putative | 0.0064 | 0.0095 | 0.0066 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2283 | 0.8699 | 1 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0335 | 0.1146 | 0.1278 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0116 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0265 | 0.0873 | 0.0846 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2618 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0144 | 0.0144 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2618 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0429 | 0.1508 | 0.1508 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0064 | 0.0095 | 0.0095 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0047 | 0.0029 | 0.0029 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0064 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2618 | 1 | 1 |
Brugia malayi | ribonucleotide reductase 2 | 0.0148 | 0.0419 | 0.0419 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0419 | 0.0391 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0047 | 0.0029 | 0.0029 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.0556 | 0.0556 |
Echinococcus multilocularis | protein patched | 0.0109 | 0.0268 | 0.0268 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0109 | 0.0268 | 0.0268 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.0556 | 0.0556 |
Echinococcus multilocularis | caspase 2 | 0.0057 | 0.0067 | 0.0067 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2283 | 0.8699 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0064 | 0.0095 | 0.0066 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0558 | 0.0558 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0335 | 0.1146 | 0.0758 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0335 | 0.1146 | 0.1288 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0116 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0244 | 0.0791 | 0.0791 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0148 | 0.0419 | 0.0419 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0077 | 0.0144 | 0.0144 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0438 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0268 | 0.0268 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0116 | 1 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0064 | 0.0095 | 0.0066 |
Brugia malayi | glutathione reductase | 0.0061 | 0.0083 | 0.0083 |
Plasmodium falciparum | glutathione reductase | 0.0061 | 0.0083 | 0.0054 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0148 | 0.0419 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0067 | 0.0067 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0148 | 0.0419 | 0.045 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0064 | 0.0095 | 0.0095 |
Plasmodium falciparum | plasmepsin I | 0.0064 | 0.0095 | 0.0066 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0061 | 0.0083 | 0.0083 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0061 | 0.0083 | 0.0054 |
Plasmodium falciparum | thioredoxin reductase | 0.0061 | 0.0083 | 0.0054 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0419 | 0.0391 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0116 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0047 | 0.0029 | 0.0029 |
Plasmodium falciparum | plasmepsin VI | 0.0064 | 0.0095 | 0.0066 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0167 | 0.0491 | 0.0491 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2618 | 1 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0064 | 0.0095 | 0.0066 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2618 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0144 | 0.0144 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.0556 | 0.0556 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0144 | 0.0144 |
Schistosoma mansoni | patched 1 | 0.0109 | 0.0268 | 0.0268 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0057 | 0.0067 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2618 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0419 | 0.0391 |
Mycobacterium leprae | conserved hypothetical protein | 0.0335 | 0.1146 | 0.1278 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0109 | 0.0268 | 0.0268 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0047 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0244 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0095 | 0.0095 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0057 | 0.0067 | 0.0067 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.0556 | 0.0556 |
Brugia malayi | hypothetical protein | 0.007 | 0.0116 | 0.0116 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0144 | 0.0144 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2618 | 1 | 1 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0821 | 0.3028 | 0.3459 |
Plasmodium vivax | ribonucleotide reductase small subunit, putative | 0.005 | 0.004 | 0.0011 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0157 | 0.0455 | 0.0455 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2618 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0047 | 0.0029 | 0.0029 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0047 | 0.0029 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0873 | 0.0873 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0109 | 0.0268 | 0.0268 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0109 | 0.0268 | 0.0276 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.07 | 0.2561 | 0.2539 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0265 | 0.0873 | 0.0873 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0061 | 0.0083 | 0.0083 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0047 | 0.0029 | 0.0029 |
Leishmania major | trypanothione reductase | 0.0061 | 0.0083 | 0.0054 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0109 | 0.0268 | 0.0268 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0244 | 0.0791 | 0.0791 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0047 | 0.0029 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | glutathione reductase | 0.0061 | 0.0083 | 0.0083 |
Echinococcus granulosus | GPCR family 2 | 0.0077 | 0.0144 | 0.0144 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0265 | 0.0873 | 0.0846 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0265 | 0.0873 | 0.0846 |
Brugia malayi | CHE-14 protein | 0.0109 | 0.0268 | 0.0268 |
Toxoplasma gondii | thioredoxin reductase | 0.0061 | 0.0083 | 0.0054 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0265 | 0.0873 | 0.0873 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2618 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.005 | 0.004 | 0.0011 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0064 | 0.0095 | 0.0076 |
Brugia malayi | Cell death protein 3 precursor | 0.0057 | 0.0067 | 0.0067 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0148 | 0.0419 | 0.045 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2618 | 1 | 1 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0029 | 0.0029 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.0556 | 0.0556 |
Echinococcus granulosus | caspase 2 | 0.0057 | 0.0067 | 0.0067 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2283 | 0.8699 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0491 | 0.0491 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0077 | 0.0144 | 0.0144 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.0116 | 0.0116 |
Plasmodium falciparum | plasmepsin II | 0.0064 | 0.0095 | 0.0066 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0265 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0077 | 0.0144 | 0.0144 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.0327 | 0.0344 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0109 | 0.0268 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0791 | 0.0791 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0265 | 0.0873 | 0.0873 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0109 | 0.0268 | 0.0268 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0148 | 0.0419 | 0.0391 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2283 | 0.8699 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.0327 | 0.0344 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0077 | 0.0144 | 0.0144 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2283 | 0.8699 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0157 | 0.0455 | 0.0455 |
Trypanosoma brucei | trypanothione reductase | 0.0061 | 0.0083 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0558 | 0.0558 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0077 | 0.0144 | 0.0144 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.0148 | 0.0419 | 0.0391 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0148 | 0.0419 | 0.0419 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0265 | 0.0873 | 0.0962 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.005 | 0.004 | 0.0011 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0077 | 0.0144 | 0.0144 |
Echinococcus multilocularis | protein dispatched 1 | 0.0109 | 0.0268 | 0.0268 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0438 | 0.1545 | 0.1545 |
Brugia malayi | Thioredoxin reductase | 0.0061 | 0.0083 | 0.0083 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0064 | 0.0095 | 0.0066 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0265 | 0.0873 | 0.0846 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit beta | 0.0148 | 0.0419 | 0.0391 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2618 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.0116 | 0.0116 |
Echinococcus multilocularis | GPCR, family 2 | 0.0077 | 0.0144 | 0.0144 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0124 | 0.0327 | 0.0344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 3.5 RFU min-1 | Nucleocapsid p7 protein (NCp7) zinc finger domain reactivity was measured by Trp37 fluorescence assay expressed as the average decrease in relative fluorescence units over 30 min | ChEMBL. | 9888834 |
EC50 (functional) | = 2.8 uM | Effective antiviral concentration against HIV-1 infected CEM-SS cells | ChEMBL. | 9888834 |
IC50 (functional) | = 43.7 uM | Antiviral activity against HIV-1 infected CEM-SS cells was determined in XTT cytoprotection assay | ChEMBL. | 9888834 |
TI (ADMET) | = 15.6 | Therapeutic index (EC50 / IC50) | ChEMBL. | 9888834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.