Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1926 | 0.589 | 0.4101 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.2844 | 0.9831 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.2844 | 0.9831 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.2884 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0792 | 0.1023 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0792 | 0.1023 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0792 | 0.1023 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.2884 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.2844 | 0.9831 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 2050 uM | Inhibitory activity against phosphodiesterase using 1 uM cyclic-AMP as substrate in bovine heart | ChEMBL. | 6273558 |
Relative potency (binding) | = 0.1 | Relative potency of compound to that of theophylline against phosphodiesterase from bovine heart | ChEMBL. | 6273558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.