Detailed information for compound 300622

Basic information

Technical information
  • TDR Targets ID: 300622
  • Name: (2S)-5-[amino(methylsulfanyl)methylidene]azan iumyl-2-azaniumylpentanoate
  • MW: 206.286 | Formula: C7H16N3O2S+
  • H donors: 3 H acceptors: 2 LogP: -2.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSC(=[NH2+])NCCC[C@H](C(=O)O)N
  • InChi: 1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/p+1/t5-/m0/s1
  • InChiKey: NGVMVBQRKZPFLB-YFKPBYRVSA-O  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-5-[amino(methylsulfanyl)methylene]ammonio-2-azaniumyl-pentanoate
  • (2S)-5-[amino-(methylthio)methylene]ammonio-2-ammoniopentanoate
  • (2S)-2-azaniumyl-5-[azanyl(methylsulfanyl)methylidene]azaniumyl-pentanoate
  • (2S)-5-[amino-(methylthio)methylene]ammonio-2-ammonio-valerate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0533 0.1679
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1429 0.1654
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0315 0.0347
Loa Loa (eye worm) hypothetical protein 0.0123 0.1235 0.1414
Mycobacterium ulcerans beta-lactamase 0.0035 0.023 0.1361
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0229 0.0213
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0315 0.0726
Leishmania major protein kinase, putative 0.0061 0.0533 0.1679
Brugia malayi Protein kinase domain containing protein 0.0061 0.0533 0.0601
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.023 0.0202
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0057 0.0181
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0315 0.0991
Echinococcus multilocularis GPCR, family 2 0.0031 0.0189 0.0174
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0094 0.032
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0057 0.0021
Schistosoma mansoni diflavin oxidoreductase 0.0059 0.0504 0.0583
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Echinococcus multilocularis SWI:SNF matrix associated 0.0768 0.864 0.8638
Brugia malayi CXXC zinc finger family protein 0.0028 0.0155 0.0161
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0273 0.2964 0.933
Brugia malayi Pre-SET motif family protein 0.0037 0.0251 0.0273
Entamoeba histolytica type A flavoprotein, putative 0.0045 0.035 0.0841
Brugia malayi Cytochrome P450 family protein 0.0018 0.0039 0.0028
Leishmania major hypothetical protein, conserved 0.0273 0.2964 0.933
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0057 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.023 0.0202
Echinococcus granulosus tumor protein p63 0.0677 0.7593 0.8786
Entamoeba histolytica type A flavoprotein, putative 0.0045 0.035 0.0841
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0768 0.864 1
Leishmania major hypothetical protein, conserved 0.0273 0.2964 0.933
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0768 0.0873
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0273 0.2964 0.933
Chlamydia trachomatis DNA topoisomerase I 0.0768 0.864 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1235 0.132
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0219
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0485 0.0545
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0441 0.1389
Schistosoma mansoni cytochrome P450 reductase 0.0118 0.1187 0.1374
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0485 0.0545
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0189 0.0174
Onchocerca volvulus 0.0099 0.0967 0.1005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0099 0.0083
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0045 0.035 0.11
Trypanosoma brucei hypothetical protein, conserved 0.0273 0.2964 0.933
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0273 0.2964 0.933
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0104 0.0089
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0768 0.864 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1491 1
Schistosoma mansoni smad 0.0016 0.0015 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0486 0.0519
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0057 0.0181
Plasmodium vivax serine/threonine kinase-1, putative 0.0061 0.0533 0.0555
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1429 0.1639
Brugia malayi MH2 domain containing protein 0.0237 0.2544 0.2932
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0533 0.1679
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0273 0.2964 0.3419
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1441 0.5982
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0315 0.03
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0533 0.1679
Echinococcus multilocularis SWI:SNF matrix associated 0.0768 0.864 0.8638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1429 0.1654
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0273 0.2964 0.933
Loa Loa (eye worm) hypothetical protein 0.0042 0.0315 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0057 0.0181
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0045 0.035 0.0341
Trypanosoma brucei trypanothione reductase 0.0057 0.0485 0.1527
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.002 0.0057 0.0178
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2383 1
Trypanosoma brucei hypothetical protein, conserved 0.0273 0.2964 0.933
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0138 0.0435
Echinococcus granulosus zinc finger protein Ran binding 0.0273 0.2964 0.3419
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0118 0.1187 0.1174
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0105 0.1033 0.1138
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0768 0.864 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0315 0.0347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1429 0.1416
Echinococcus granulosus GPCR family 2 0.0031 0.0189 0.0202
Echinococcus granulosus hypothetical protein 0.0059 0.0507 0.0571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1324 0.5482
Mycobacterium leprae conserved hypothetical protein 0.0024 0.011 0.0485
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0057 0.0181
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0189 0.0174
Schistosoma mansoni TRABID protein (C64 family) 0.0273 0.2964 0.3431
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0099 0.0114
Loa Loa (eye worm) hypothetical protein 0.0273 0.2964 0.3419
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0273 0.2964 0.3419
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0768 0.864 1
Echinococcus granulosus geminin 0.0176 0.1846 0.2123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0189 0.0202
Brugia malayi Cytochrome P450 family protein 0.006 0.0519 0.0583
Giardia lamblia Hypothetical protein 0.0105 0.1033 0.3218
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0273 0.2964 0.933
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.0724
Onchocerca volvulus 0.0768 0.864 1
Leishmania major cytochrome p450-like protein 0.0018 0.0039 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0118 0.1187 0.3737
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1491 0.6193
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0043
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0039 0.0124
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2719 0.3135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Schistosoma mansoni cpg binding protein 0.0032 0.0194 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0202
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0057 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0441 0.1389
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0273 0.2964 0.3346
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0315 0.03
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0768 0.0873
Echinococcus multilocularis dual specificity mitogen activated protein 0.0292 0.3177 0.3166
Loa Loa (eye worm) hypothetical protein 0.0273 0.2964 0.3419
Brugia malayi Pre-SET motif family protein 0.0252 0.2719 0.3135
Schistosoma mansoni cytochrome P450 0.0018 0.0039 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0019 0.0004
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0273 0.2964 0.2953
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1429 0.1416
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0229 0.0247
Mycobacterium ulcerans hypothetical protein 0.0035 0.023 0.1361
Schistosoma mansoni brg-1 associated factor 0.0768 0.864 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0315 0.03
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0189 0.0202
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0315 0.0991
Schistosoma mansoni zinc finger protein 0.0021 0.0066 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0315 0.0301
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0138 0.0435
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0892 0.3638
Mycobacterium ulcerans lipase LipD 0.0035 0.023 0.1361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1441 0.966
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.023 0.0249
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0094 0.0393
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0045 0.035 0.0341
Schistosoma mansoni fusion 0.0273 0.2964 0.3431
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0094 0.0393
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0315 0.0364
Schistosoma mansoni hypothetical protein 0.0768 0.864 1
Brugia malayi flavodoxin family protein 0.0118 0.1187 0.1359
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0202
Brugia malayi SWIB/MDM2 domain containing protein 0.0768 0.864 1
Entamoeba histolytica type A flavoprotein, putative 0.0045 0.035 0.0841
Echinococcus granulosus dnaJ subfamily B 0.0402 0.4445 0.5136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0533 0.0617
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0273 0.2964 0.933
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Mycobacterium leprae Probable lipase LipE 0.0035 0.023 0.1315
Brugia malayi Bromodomain containing protein 0.0074 0.068 0.077
Echinococcus multilocularis zinc finger protein 0.0021 0.0066 0.005
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0045 0.035 0.0341
Loa Loa (eye worm) hypothetical protein 0.0099 0.0965 0.1101
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0814
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0045 0.035 0.034
Schistosoma mansoni RNA binding protein 0.0273 0.2964 0.3431
Onchocerca volvulus 0.0035 0.023 0.0141
Echinococcus granulosus zinc finger protein 0.0021 0.0066 0.0058
Mycobacterium ulcerans hypothetical protein 0.0024 0.011 0.0502
Brugia malayi beta-lactamase 0.0035 0.023 0.0249
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0219
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0892 0.5874
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.3128 0.9844
Brugia malayi hypothetical protein 0.0053 0.0441 0.0494
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1324 0.5482
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.023 0.0814
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.023 0.0814
Loa Loa (eye worm) hypothetical protein 0.0099 0.0967 0.1103
Brugia malayi flavodoxin family protein 0.0045 0.035 0.0387
Brugia malayi Cytochrome P450 family protein 0.0027 0.0138 0.0142
Toxoplasma gondii endonuclease IV APN 0.0093 0.0892 0.0991
Loa Loa (eye worm) cytochrome P450 0.0018 0.0039 0.0028
Echinococcus granulosus methionine synthase reductase 0.0073 0.0668 0.0757
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0121 0.1213 0.3819
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0073 0.0668 0.0774
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0441 0.0447
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0045 0.035 0.11
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0441 0.0447
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.023 0.1361
Loa Loa (eye worm) brahma associated protein 0.0768 0.864 1
Toxoplasma gondii ran binding protein 0.0273 0.2964 0.3401
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0892 0.0972
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0118 0.1187 0.3737
Schistosoma mansoni protein kinase 0.0292 0.3177 0.3677
Brugia malayi PHD-finger family protein 0.0026 0.0125 0.0127
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0121 0.1213 0.3819
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1491 0.6193
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0519 0.0583
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0533 0.0555
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0251 0.029
Loa Loa (eye worm) FAD binding domain-containing protein 0.0073 0.0668 0.0757
Echinococcus multilocularis zinc finger protein Ran binding 0.0273 0.2964 0.2953
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0104 0.0103
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0292 0.3177 1
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative 0.002 0.0057 0.0178
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0273 0.2964 0.2953
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.023 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0441 0.0467
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.4445 0.4436
Echinococcus multilocularis 0.0018 0.0039 0.0024
Brugia malayi hypothetical protein 0.0123 0.1235 0.1414
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0045 0.035 0.034
Brugia malayi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0074 0.0678 0.0768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.051 0.0496
Schistosoma mansoni zinc finger protein 0.0273 0.2964 0.3431
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0094 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.023 0.0814
Chlamydia trachomatis endonuclease IV 0.0093 0.0892 0.0972
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0533 0.0617
Onchocerca volvulus 0.0287 0.3117 0.3526
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0138 0.0142
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1441 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1324 0.5482
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3128 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0485 0.1903
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0057 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2544 0.2932
Leishmania major trypanothione reductase 0.0057 0.0485 0.1527
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0016 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0057 0.0181
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0219
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0094 0.0235
Toxoplasma gondii ABC1 family protein 0.0035 0.023 0.0222
Trichomonas vaginalis STE family protein kinase 0.0292 0.3177 0.3635
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0967 0.1119
Loa Loa (eye worm) hypothetical protein 0.0053 0.0441 0.0494
Onchocerca volvulus 0.0035 0.023 0.0141
Onchocerca volvulus 0.0082 0.0768 0.0772
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0814
Loa Loa (eye worm) hypothetical protein 0.0068 0.0614 0.0694
Echinococcus multilocularis dual specificity protein kinase clk2 0.0061 0.0533 0.0519
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3117 0.3566
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0315 0.0364
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0292 0.3177 0.3666
Echinococcus multilocularis geminin 0.0176 0.1846 0.1834
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0251 0.0236
Loa Loa (eye worm) hypothetical protein 0.0273 0.2964 0.3419
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0485 0.1527
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0814
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0061 0.0533 0.0601
Onchocerca volvulus 0.0028 0.0155 0.0053
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0018
Leishmania major hypothetical protein, conserved 0.0053 0.0441 0.1389
Echinococcus granulosus dual specificity protein kinase clk2 0.0061 0.0533 0.0601
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0273 0.2964 0.3419
Echinococcus multilocularis SWI:SNF matrix associated 0.0768 0.864 0.8638
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0057 0.0066
Onchocerca volvulus Huntingtin homolog 0.0123 0.1235 0.132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.023 0.0814
Treponema pallidum flavodoxin 0.0045 0.035 0.0951
Leishmania major p450 reductase, putative 0.0118 0.1187 0.3737
Leishmania major hypothetical protein, conserved 0.0273 0.2964 0.933
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0768 0.864 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0355
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0892 0.0972
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0057 0.013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0768 0.0754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Schistosoma mansoni hypothetical protein 0.0768 0.864 1
Trypanosoma cruzi hypothetical protein, conserved 0.0273 0.2964 0.933
Brugia malayi Bromodomain containing protein 0.0037 0.0255 0.0277
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1491 0.6193
Giardia lamblia Kinase, CMGC CLK 0.0061 0.0533 0.1637
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0118 0.1187 0.1359
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0045 0.035 0.11
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0273 0.2964 0.3419
Plasmodium vivax glutathione reductase, putative 0.0057 0.0485 0.0498
Trichomonas vaginalis sulfite reductase, putative 0.0118 0.1187 0.1317
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1324 0.5482
Mycobacterium tuberculosis Probable reductase 0.013 0.1324 0.5482
Schistosoma mansoni hypothetical protein 0.0176 0.1846 0.2137
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0057 0.0181
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0315 0.0991
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0109
Toxoplasma gondii flavodoxin domain-containing protein 0.0059 0.0504 0.054
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0768 0.0889
Echinococcus granulosus SWI:SNF matrix associated 0.0768 0.864 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.0724
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0315 0.0347
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0138 0.0705
Loa Loa (eye worm) FAD binding domain-containing protein 0.0118 0.1187 0.1359
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0118 0.1187 0.1174
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0138 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Schistosoma mansoni NADPH flavin oxidoreductase 0.006 0.0514 0.0595
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.011 0.03
Entamoeba histolytica type A flavoprotein, putative 0.0045 0.035 0.0841
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.044 0.0492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1429 0.1639
Leishmania major cytochrome p450-like protein 0.0018 0.0039 0.0124
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0059 0.0051
Echinococcus multilocularis ring and YY1 binding protein 0.0273 0.2964 0.2953
Schistosoma mansoni hypothetical protein 0.0024 0.0104 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.023 0.0724
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0118 0.1187 0.3737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0251 0.029
Leishmania major hypothetical protein, conserved 0.0273 0.2964 0.933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1429 0.1654
Plasmodium falciparum thioredoxin reductase 0.0057 0.0485 0.0498
Leishmania major hypothetical protein, conserved 0.0035 0.023 0.0724
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0039 0.0124
Loa Loa (eye worm) glutathione reductase 0.0057 0.0485 0.0545
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0045 0.035 0.11
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.044 0.0509
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0118 0.1187 0.8189
Echinococcus multilocularis cpg binding protein 0.0032 0.0194 0.0179
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0057 0.0181
Brugia malayi beta-lactamase family protein 0.0035 0.023 0.0249
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0061 0.0533 0.1679
Schistosoma mansoni cpg binding protein 0.0028 0.0155 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.011 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Plasmodium vivax hypothetical protein, conserved 0.0045 0.035 0.034
Plasmodium falciparum nitric oxide synthase, putative 0.0118 0.1187 0.1317
Chlamydia trachomatis sulfite reductase 0.0073 0.0668 0.0712
Giardia lamblia Nitric oxide synthase, inducible 0.0105 0.1033 0.3218
Plasmodium vivax flavodoxin domain containing protein 0.0105 0.1033 0.1137
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0315 0.0301
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0039 0.0124
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.023 0.0814
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0057 0.0181
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0768 0.864 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0533 0.1679
Leishmania major hypothetical protein, conserved 0.0273 0.2964 0.933
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0485 0.0498
Brugia malayi cytochrome P450 0.0018 0.0039 0.0028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0315 0.0301
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0057 0.0131
Plasmodium vivax hypothetical protein, conserved 0.0768 0.864 1
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0039 0.0028
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0057 0.0001
Onchocerca volvulus 0.0037 0.0251 0.0166
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0965 0.1101
Loa Loa (eye worm) flavodoxin family protein 0.0045 0.035 0.0387
Brugia malayi FAD binding domain containing protein 0.0073 0.0668 0.0757
Toxoplasma gondii thioredoxin reductase 0.0057 0.0485 0.0519
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0292 0.3177 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0059 0.0504 0.054
Echinococcus granulosus ring and YY1 binding protein 0.0273 0.2964 0.3419
Trypanosoma cruzi hypothetical protein, conserved 0.0273 0.2964 0.933
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0057 0.013
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0019 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.023 0.0814
Schistosoma mansoni hypothetical protein 0.0768 0.864 1
Plasmodium vivax SET domain protein, putative 0.0037 0.0251 0.0225
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.051 0.0574
Entamoeba histolytica 2,3-bisphosphoglycerate-independentphosphoglycerate mutase, putative 0.0066 0.0592 0.1641
Loa Loa (eye worm) hypothetical protein 0.0053 0.044 0.0492
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0189 0.0202
Trypanosoma cruzi WLM domain containing protein, putative 0.0273 0.2964 0.933
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0026 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0965 0.1101
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0273 0.2964 0.3387
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0219
Giardia lamblia Kinase, STE STE20 0.0292 0.3177 1
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like 0.002 0.0057 0.0178
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0094 0.038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Schistosoma mansoni hypothetical protein 0.0273 0.2964 0.3431
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.023 0.0249
Brugia malayi glutathione reductase 0.0057 0.0485 0.0545
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0315 0.0347
Schistosoma mansoni hypothetical protein 0.0402 0.4445 0.5145
Onchocerca volvulus 0.0273 0.2964 0.3346
Brugia malayi Thioredoxin reductase 0.0057 0.0485 0.0545
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0094 0.012
Entamoeba histolytica type A flavoprotein, putative 0.0045 0.035 0.0841
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0121 0.1213 0.3819
Mycobacterium ulcerans epimerase 0.0024 0.011 0.0502
Loa Loa (eye worm) hypothetical protein 0.0118 0.1187 0.1359
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0118 0.1187 0.1317
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0057 0.0181
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0189 0.0202
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0892 0.1016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0965 0.1101
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0606 0.0685
Trypanosoma cruzi hypothetical protein, conserved 0.0273 0.2964 0.933
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0094 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.023 0.0249
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0485 0.0471
Brugia malayi hypothetical protein 0.0034 0.0225 0.0243
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0057 0.0021
Schistosoma mansoni hypothetical protein 0.0068 0.0606 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0441 0.0447
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0045 0.035 0.0341
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0315 0.0945
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0278
Brugia malayi YY1-associated factor 2 0.0273 0.2964 0.3419
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0768 0.864 0.8638
Loa Loa (eye worm) hypothetical protein 0.0123 0.1235 0.1414
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0251 0.0246
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2544 0.2932
Loa Loa (eye worm) hypothetical protein 0.0273 0.2964 0.3419
Brugia malayi FAD binding domain containing protein 0.0118 0.1187 0.1359
Loa Loa (eye worm) hypothetical protein 0.0039 0.0282 0.0309
Schistosoma mansoni hypothetical protein 0.0176 0.1846 0.2137
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1324 0.5482
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3128 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0118 0.1187 0.3737
Echinococcus granulosus dual specificity mitogen activated protein 0.0292 0.3177 0.3666
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0118 0.1187 0.3737
Plasmodium vivax hypothetical protein, conserved 0.0035 0.023 0.0201
Plasmodium falciparum protein serine/threonine kinase-1 0.0061 0.0533 0.0555
Trypanosoma cruzi WLM domain containing protein, putative 0.0273 0.2964 0.933
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0118 0.1187 0.3737
Plasmodium falciparum glutathione reductase 0.0057 0.0485 0.0498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.023 0.0266
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.044 0.0425
Wolbachia endosymbiont of Brugia malayi phosphoglyceromutase 0.0121 0.1213 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0273 0.2964 0.3401
Schistosoma mansoni hypothetical protein 0.002 0.0059 0.0068
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0118 0.1187 0.3737
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0061 0.0533 0.1679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.023 0.0266
Loa Loa (eye worm) hypothetical protein 0.0059 0.0507 0.0571
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0273 0.2964 0.3419
Echinococcus multilocularis 0.0059 0.0507 0.0493
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0138 0.0142
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0094 0.0297
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.011 0.0502
Loa Loa (eye worm) hypothetical protein 0.0068 0.0606 0.0685
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0249
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0292 0.3177 0.3666
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1429 0.1639
Leishmania major hypothetical protein, conserved 0.0045 0.035 0.11
Echinococcus granulosus cpg binding protein 0.0032 0.0194 0.0207
Onchocerca volvulus 0.0035 0.023 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.864 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0768 0.0873
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0094 0.0043
Brugia malayi Cytochrome P450 family protein 0.0027 0.0138 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1429 0.1639
Loa Loa (eye worm) hypothetical protein 0.0273 0.2964 0.3419
Giardia lamblia Kinase, NEK 0.0016 0.0016 0.000000054766
Loa Loa (eye worm) independent phosphoglycerate mutase isoform 2 0.0121 0.1213 0.1389
Onchocerca volvulus 0.0273 0.2964 0.3346
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0273 0.2964 0.933
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0189 0.0202
Onchocerca volvulus 0.0273 0.2964 0.3346
Mycobacterium ulcerans endonuclease IV 0.0093 0.0892 0.6081
Echinococcus multilocularis tumor protein p63 0.0677 0.7593 0.7589
Brugia malayi brahma associated protein 60 kDa 0.0768 0.864 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0202
Onchocerca volvulus 0.0273 0.2964 0.3346
Entamoeba histolytica 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0121 0.1213 0.3689
Loa Loa (eye worm) hypothetical protein 0.0093 0.0892 0.1016
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0061 0.0533 0.0575
Mycobacterium leprae conserved hypothetical protein 0.0035 0.023 0.1315
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0229 0.0247
Echinococcus multilocularis methionine synthase reductase 0.0073 0.0668 0.0654
Trichomonas vaginalis STE family protein kinase 0.0292 0.3177 0.3635
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0138 0.0435
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.3128 1
Giardia lamblia 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0121 0.1213 0.3788
Trypanosoma cruzi p450 reductase, putative 0.0118 0.1187 0.3737
Chlamydia trachomatis SWIB complex protein 0.0768 0.864 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0019 0.0022
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0768 0.864 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3128 0.3578
Leishmania major protein kinase, putative 0.0061 0.0533 0.1679
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0118 0.1187 0.3737
Echinococcus granulosus Zinc finger RanBP2 type 0.0273 0.2964 0.3419
Trichomonas vaginalis esterase, putative 0.0035 0.023 0.0202
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0315 0.0991
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0057 0.013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0057 0.0078
Trichomonas vaginalis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0121 0.1213 0.1348
Brugia malayi brahma associated protein 60 kDa 0.0768 0.864 1
Leishmania major cytochrome P450 reductase, putative 0.0105 0.1033 0.3252
Trichomonas vaginalis STE family protein kinase 0.0292 0.3177 0.3635
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.002 0.0057 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0057 0.0181
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1324 0.8852
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0099 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0441 0.1389
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0202
Loa Loa (eye worm) beta-lactamase 0.0035 0.023 0.0249
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0057 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.023 0.1361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.044 0.0509
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0533 0.0617
Leishmania major cytochrome p450-like protein 0.0027 0.0138 0.0435
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0039 0.0124
Schistosoma mansoni Smad4 0.0016 0.0015 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0094 0.0297
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0039 0.0124
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.023 0.0814
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0155 0.0161
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0118 0.1187 0.1359
Brugia malayi beta-lactamase family protein 0.0035 0.023 0.0249
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0292 0.3177 1
Schistosoma mansoni cpg binding protein 0.0032 0.0194 0.0225
Schistosoma mansoni bromodomain containing protein 0.0063 0.055 0.0636

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 29 % In vivo inhibition of inducible Nitric oxide Synthase ( iNOS) in anesthtized rats at concentration of 1 microM ChEMBL. 7512141
Inhibition (binding) = 73 % In vivo inhibition of brain tissue Nitric oxide Synthase ( bNOS) in anesthtized rats at concentration of 1 microM ChEMBL. 7512141
Inhibition (binding) = 87 % In vivo inhibition of inducible Nitric oxide Synthase ( iNOS) in anesthtized rats at concentration of 10 microM ChEMBL. 7512141
Inhibition (binding) = 96 % In vivo inhibition of brain tissue Nitric oxide Synthase ( bNOS) in anesthtized rats at concentration of 10 microM ChEMBL. 7512141
Inhibition (binding) > 99 % In vivo inhibition of brain tissue Nitric oxide Synthase ( bNOS) in anesthtized rats at concentration of 100 microM ChEMBL. 7512141
Inhibition (binding) > 99 % In vivo inhibition of inducible Nitric oxide Synthase ( iNOS) in anesthtized rats at concentration of 100 microM ChEMBL. 7512141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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