Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.0312 |
Brugia malayi | ABC transporter family protein | 0.0031 | 0.0312 | 0.0417 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0185 | 0.367 | 0.367 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0051 | 0.0746 | 0.1355 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0051 | 0.0746 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0656 | 0.0656 |
Schistosoma mansoni | hypothetical protein | 0.0286 | 0.5862 | 0.5826 |
Mycobacterium ulcerans | lipoprotein LppD | 0.0051 | 0.0746 | 0.1219 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0022 | 0.0107 | 0.0107 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0031 | 0.0312 | 0.0312 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0312 | 0.0228 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0031 | 0.0302 | 0.0302 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0021 | 0.0086 | 0.1147 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0746 | 0.0666 |
Trypanosoma brucei | RNA helicase, putative | 0.0101 | 0.1843 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0051 | 0.0746 | 0.3758 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0021 | 0.0086 | 0.1147 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0021 | 0.0086 | 0.1147 |
Loa Loa (eye worm) | glutaminase | 0.0269 | 0.5505 | 0.5466 |
Echinococcus multilocularis | 0.0021 | 0.0086 | 0.0086 | |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0031 | 0.0312 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | abcb9, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0656 | 0.1053 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0656 | 0.0575 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0185 | 0.367 | 0.367 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0302 | 0.0218 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0031 | 0.0312 | 0.0312 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0798 | 0.0798 |
Giardia lamblia | Protein LRP16 | 0.0051 | 0.0746 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.0312 | 0.0228 |
Onchocerca volvulus | 0.0031 | 0.0312 | 0.4752 | |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0051 | 0.0746 | 0.0746 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0051 | 0.0746 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0051 | 0.0746 | 0.0746 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0021 | 0.0086 | 0.0086 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0051 | 0.0746 | 0.0746 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0475 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0798 | 0.0798 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0031 | 0.0312 | 0.0312 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0051 | 0.0746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0312 | 0.0228 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus multilocularis | geminin | 0.0167 | 0.3272 | 0.3272 |
Mycobacterium ulcerans | glutaminase | 0.0269 | 0.5505 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0475 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0021 | 0.0086 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0051 | 0.0746 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0021 | 0.0086 | 0.1147 |
Trichomonas vaginalis | abcb9, putative | 0.0031 | 0.0312 | 0.0566 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0051 | 0.0746 | 1 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0031 | 0.0312 | 0.0228 |
Leishmania major | p-glycoprotein | 0.0031 | 0.0312 | 1 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0051 | 0.0746 | 0.1355 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0656 | 0.1053 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0798 | 0.0718 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3272 | 0.3214 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.032 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0656 | 0.0656 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0031 | 0.0302 | 0.0302 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0051 | 0.0746 | 0.0746 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0021 | 0.0086 | 0.1147 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0031 | 0.0312 | 0.0312 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0022 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0656 | 0.0575 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0021 | 0.0086 | 0.1147 |
Trichomonas vaginalis | ABC transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0656 | 0.0575 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0031 | 0.0312 | 0.0312 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0021 | 0.0086 | 0.1147 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0021 | 0.0086 | 0.1147 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0798 | 0.0798 |
Trichomonas vaginalis | taga, putative | 0.0031 | 0.0312 | 0.0566 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0021 | 0.0086 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0475 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0656 | 0.0575 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0475 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0031 | 0.0312 | 1 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0051 | 0.0746 | 1 |
Toxoplasma gondii | macro domain-containing protein | 0.0051 | 0.0746 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0463 | 0.9734 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.0312 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.0656 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0031 | 0.0312 | 0.0312 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0051 | 0.0746 | 0.0767 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1843 | 0.1773 |
Trichomonas vaginalis | ABC transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus granulosus | geminin | 0.0167 | 0.3272 | 0.3272 |
Trichomonas vaginalis | ABC transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Brugia malayi | Appr-1-p processing enzyme family protein | 0.0051 | 0.0746 | 0.1219 |
Schistosoma mansoni | smdr2 | 0.0031 | 0.0312 | 0.0228 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.0051 | 0.0746 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.0312 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0798 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0798 | 0.0718 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0031 | 0.0312 | 0.0312 |
Onchocerca volvulus | 0.0047 | 0.0656 | 1 | |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0022 | 0.0107 | 0.0107 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0656 | 0.0656 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0021 | 0.0086 | 0.1147 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0031 | 0.0312 | 0.4178 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0021 | 0.0086 | 0.1147 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0031 | 0.0312 | 0.4178 |
Trichomonas vaginalis | glutaminase, putative | 0.0269 | 0.5505 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0798 | 0.0718 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0656 | 0.0575 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0746 | 0.0666 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.0312 | 0.0228 |
Brugia malayi | glutaminase DH11.1 | 0.0269 | 0.5505 | 1 |
Brugia malayi | multidrug resistance protein 3 | 0.0031 | 0.0312 | 0.0417 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0021 | 0.0086 | 0.1147 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0656 | 0.0656 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0746 | 0.0666 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.0312 | 0.0228 |
Schistosoma mansoni | glutaminase | 0.0269 | 0.5505 | 0.5466 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0031 | 0.0312 | 0.0566 |
Loa Loa (eye worm) | glutaminase 2 | 0.0269 | 0.5505 | 0.5466 |
Trichomonas vaginalis | ABC transporter, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0031 | 0.0312 | 0.0312 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0021 | 0.0086 | 0.1147 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0031 | 0.0312 | 0.4178 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0031 | 0.0312 | 0.0312 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0031 | 0.0312 | 0.0312 |
Trichomonas vaginalis | abcb9, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0107 | 0.0194 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0031 | 0.0312 | 0.0228 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0031 | 0.0312 | 0.4178 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0798 | 0.1314 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3272 | 0.3214 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0031 | 0.0312 | 0.0566 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0051 | 0.0746 | 0.1355 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase in blood pressure (functional) | = 13 mmHg | Increase in diastolic blood pressure for 0.1 microg/kg intravenous dosing of noradrenaline in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 14 mmHg | Increase in diastolic blood pressure for 0.03 microg/kg intravenous dosing of angiotensin in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 25 mmHg | Increase in diastolic blood pressure for 0.3 microg/kg intravenous dosing of noradrenaline in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 28 mmHg | Increase in diastolic blood pressure for 0.1 microg/kg intravenous dosing of angiotensin in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 30 mmHg | Increase in diastolic blood pressure for 1 Htz electrical stimulation in the pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 44 mmHg | Increase in diastolic blood pressure for 0.3 microg/kg intravenous dosing of angiotensin in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 45 mmHg | Increase in diastolic blood pressure for 1.0 microg/kg intravenous dosing of noradrenaline in pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 52 mmHg | Increase in diastolic blood pressure for 3 Htz electrical stimulation in the pithed rats | ChEMBL. | 3361579 |
Increase in blood pressure (functional) | = 65 mmHg | Increase in diastolic blood pressure for 6 Htz electrical stimulation in the pithed rats | ChEMBL. | 3361579 |
Reduction (functional) | = 29 % | Maximum percentage reduction in mean blood pressure in metacorticoid (DOCA) hypertensive rats at a standard oral dose of 50 mg/kg | ChEMBL. | 3361579 |
Reduction (functional) | = 37 % | Maximum percentage reduction in mean blood pressure in metacorticoid (DOCA) hypertensive rats at a standard oral dose of 100 mg/kg | ChEMBL. | 3361579 |
Summation MABP (functional) | = 113 | Summation of percentage reductions, compared to pretreatment controls, in MABP of DOCA hypertensive rats at 1,2,3,5,8 h after the 50 mg/kg oral dose. | ChEMBL. | 3361579 |
Summation MABP (functional) | = 157 | Summation of percentage reductions, compared to pretreatment controls, in MABP of DOCA hypertensive rats at 1,2,3,5,8 h after the 100 mg/kg oral dose. | ChEMBL. | 3361579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.