Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2595 | 0.1234 | 0.1234 |
Mycobacterium ulcerans | lipase LipU | 0.0318 | 0.0001 | 1 |
Onchocerca volvulus | 0.2371 | 0.1112 | 0.9014 | |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0318 | 0.0001 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0318 | 0.0001 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0318 | 0.0001 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.0318 | 0.0001 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2595 | 0.1234 | 0.1234 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0318 | 0.0001 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0318 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.2595 | 0.1234 | 1 | |
Mycobacterium ulcerans | esterase LipW | 0.0318 | 0.0001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.8787 | 1 | 1 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0318 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.2595 | 0.1234 | 0.1234 |
Mycobacterium ulcerans | hypothetical protein | 0.0318 | 0.0001 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0318 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | esterase/lipase | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0318 | 0.0001 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2595 | 0.1234 | 0.1234 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Brugia malayi | Trypsin family protein | 0.2595 | 0.1234 | 1 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0318 | 0.0001 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0318 | 0.0001 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.8787 | 1 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0318 | 0.0001 | 1 |
Mycobacterium ulcerans | lipase LipH | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0318 | 0.0001 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Brugia malayi | aryl-acylamidase | 0.0318 | 0.0001 | 0.0007 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0318 | 0.0001 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0318 | 0.0001 | 1 |
Leishmania major | ecotin, putative | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0318 | 0.0001 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0318 | 0.0001 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C/I ratio (functional) | = 0 | In vivo activity against vaginal candidoses in rats, measured as the ratio of animals cured/animals infected (C/I) at dose 2.5 mg/kg; C/I = 0/2 | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Microsporum canis | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Trichophyton mentagrophytes | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Trichophyton rubrum | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Phialophora verrucosa | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Candida tropicalis | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Mucor sp | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Aspergillus fumigatus | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Sporothrix schenck ii | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Saprolegnia sp | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.