Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0425 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0425 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0425 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0425 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(binding) | = 76.51 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei | ChEMBL. | 14695838 |
I50 (binding) | 0 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from Candida albicans; No data | ChEMBL. | 14695838 |
I50 (binding) | = 9.6 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from M. lufu (DDS resistant) | ChEMBL. | 14695838 |
I50 (binding) | = 12.72 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from M. lufu (DDS sensitive) | ChEMBL. | 14695838 |
I50 (binding) | = 155.39 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from Escherichia coli | ChEMBL. | 14695838 |
Inhibition (binding) | = 76.51 uM | Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei | ChEMBL. | 14695838 |
pC (binding) | = 4.9 | In vitro inhibition of Mycobacterium lufu dihydopterate synthase. | ChEMBL. | 3572979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.