Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0011 | 0.0664 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.0032 | 0.0032 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0307 | 0.0158 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0027 | 0.0003 | 0.022 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0664 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0027 | 0.0003 | 0.0003 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0307 | 0.0158 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0664 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0307 | 0.0158 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0011 | 0.0664 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | esterase LipW | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | esterase LipC | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.0129 | 0.816 |
Loa Loa (eye worm) | hypothetical protein | 1.8102 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0307 | 0.0158 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.0307 | 0.0158 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0027 | 0.0003 | 0.022 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0307 | 0.0158 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8102 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0011 | 0.0664 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0011 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0664 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0307 | 0.0158 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0026 | 0.0026 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0307 | 0.0158 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.0026 | 0.1619 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0307 | 0.0158 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.0032 | 0.0032 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.0026 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.1619 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0011 | 0.0664 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0011 | 0.0664 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.0032 | 0.2053 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8102 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.0032 | 0.2053 |
Leishmania major | ecotin, putative | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0307 | 0.0158 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | esterase/lipase | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0011 | 0.0664 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.1619 |
Trichomonas vaginalis | Esterase, putative | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0027 | 0.0003 | 0.022 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0307 | 0.0158 | 1 |
Brugia malayi | aryl-acylamidase | 0.0307 | 0.0158 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0235 | 0.0118 | 0.7492 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0011 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0011 | 0.0664 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.1619 |
Mycobacterium ulcerans | esterase LipO | 0.0307 | 0.0158 | 1 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0003 | 0.022 |
Mycobacterium ulcerans | lipase LipU | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0307 | 0.0158 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0011 | 0.0664 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0003 | 0.022 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0307 | 0.0158 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | lipase LipH | 0.0307 | 0.0158 | 1 |
Loa Loa (eye worm) | ammd protein | 0.0307 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0027 | 0.0003 | 0.022 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0011 | 0.0664 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0027 | 0.0003 | 0.022 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0027 | 0.0003 | 0.0003 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0307 | 0.0158 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Brugia malayi | beta-lactamase | 0.004 | 0.0011 | 0.0664 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0011 | 0.0664 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0307 | 0.0158 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.0032 | 0.0032 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.0058 | 0.3696 |
Onchocerca volvulus | 0.0307 | 0.0158 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0307 | 0.0158 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0664 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0307 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | hypothetical protein | 0.0307 | 0.0158 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0011 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Leishmania major | hypothetical protein, conserved | 0.0235 | 0.0118 | 0.7492 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0027 | 0.0003 | 0.022 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0011 | 0.0664 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0003 | 0.022 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0235 | 0.0118 | 0.7492 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.0026 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.1619 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0307 | 0.0158 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0307 | 0.0158 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0307 | 0.0158 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0307 | 0.0158 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0307 | 0.0158 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0011 | 0.0011 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0307 | 0.0158 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0235 | 0.0118 | 0.7492 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0026 | 0.1619 |
Trichomonas vaginalis | Esterase, putative | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0307 | 0.0158 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0011 | 0.0664 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0895 | 0.0484 | 0.0484 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0011 | 0.0664 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8102 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0307 | 0.0158 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0011 | 0.0664 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0011 | 0.0664 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.8102 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0307 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0011 | 0.0664 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0079 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0011 | 0.0011 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0011 | 0.0011 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0003 | 0.022 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0003 | 0.022 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.0058 | 0.0058 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0011 | 0.0664 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0011 | 0.0664 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 92 % | In vitro cytotoxicity against growth rate of L1210 cell at 100 micro M was evaluated. | ChEMBL. | 8632411 |
Control (functional) | = 92 % | In vitro cytotoxicity against growth rate of L1210 cell at 100 micro M was evaluated. | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Antiviral activity against Human Cytomegalovirus (HCMV) replication in a plaque reduction assay | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Antiviral activity against HSV-1 replication was evaluated by ELISA | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Cytotoxic activity tested against exponentially growing KB cells, determined by staining method | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay | ChEMBL. | 8632411 |
IC50 (functional) | > 100 uM | Cytotoxic activity tested against exponentially growing KB cells, determined by staining method | ChEMBL. | 8632411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.