Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable esterase LipO | 0.0318 | 0.0001 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 1.8787 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0318 | 0.0001 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0318 | 0.0001 | 1 |
Brugia malayi | Trypsin family protein | 0.2595 | 0.1234 | 1 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0318 | 0.0001 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2595 | 0.1234 | 0.1234 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0318 | 0.0001 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Leishmania major | ecotin, putative | 0.0318 | 0.0001 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0318 | 0.0001 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0318 | 0.0001 | 1 |
Brugia malayi | aryl-acylamidase | 0.0318 | 0.0001 | 0.0007 |
Mycobacterium ulcerans | lipase LipU | 0.0318 | 0.0001 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0318 | 0.0001 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0318 | 0.0001 | 1 |
Mycobacterium ulcerans | esterase LipO | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0318 | 0.0001 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0318 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0318 | 0.0001 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0318 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.2371 | 0.1112 | 0.9014 | |
Mycobacterium ulcerans | lipase LipU | 0.0318 | 0.0001 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2595 | 0.1234 | 0.1234 |
Loa Loa (eye worm) | hypothetical protein | 0.2595 | 0.1234 | 0.1234 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0318 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | hypothetical protein | 0.0318 | 0.0001 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0318 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 1.8787 | 1 | 1 |
Mycobacterium ulcerans | esterase LipW | 0.0318 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0318 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.2595 | 0.1234 | 1 | |
Loa Loa (eye worm) | ammd protein | 0.0318 | 0.0001 | 0.0001 |
Leishmania major | hypothetical protein, conserved | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0318 | 0.0001 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2595 | 0.1234 | 0.1234 |
Trichomonas vaginalis | Esterase, putative | 0.0318 | 0.0001 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.0318 | 0.0001 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.8787 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0318 | 0.0001 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C/I ratio (functional) | = 0 | In vivo activity against microsporosis guinea pig, measured as the ratio of animals cured/animals infected (C/I) at dose 2.5 mg/kg; C/I = 0/2 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 2 | In vivo activity against vaginal candidoses in rats, measured as the ratio of animals cured/animals infected (C/I) at dose 2.5 mg/kg; C/I = 2/4 | ChEMBL. | 6330360 |
C/I ratio (functional) | = 2 | In vivo activity against microsporosis guinea pig, measured as the ratio of animals cured/animals infected (C/I) at dose 10 mg/kg; C/I = 2/2 | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Microsporum canis | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Trichophyton mentagrophytes | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Trichophyton rubrum | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Phialophora verrucosa | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Candida tropicalis | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Mucor sp | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Aspergillus fumigatus | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Sporothrix schenck ii | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Saprolegnia sp | ChEMBL. | 6330360 |
Inhibition (functional) | = 100 ug ml-1 | In vitro antifungal activity against Cryptococcus neoformans | ChEMBL. | 6330360 |
Inhibition (functional) | > 100 ug ml-1 | In vitro antifungal activity against Candida albicans | ChEMBL. | 6330360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.