Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | esterase LipW | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.4762 | 1 | 1 |
Leishmania major | ecotin, putative | 0.025 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4762 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.025 | 0 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.025 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4762 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.025 | 0 | 0.5 |
Onchocerca volvulus | 0.025 | 0 | 0.5 | |
Mycobacterium ulcerans | lipase LipU | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.025 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.025 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.025 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.025 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.025 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.025 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.025 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.025 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4762 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.025 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.025 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.4762 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.025 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.025 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.025 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.025 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.025 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase (functional) | = -4 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 25 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = -4 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 25 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = -2 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 50 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = -2 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 50 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 0 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 100 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 0 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 200 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 0 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 100 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 0 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 200 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 4 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 12.5 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Increase (functional) | = 4 % | Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 12.5 mg/kg , daily x 5 | ChEMBL. | 6737430 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.