Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0201 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0201 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0201 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0201 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1854 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0201 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0201 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0201 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.1854 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0201 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0201 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0201 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0201 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.1854 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0201 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0201 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1854 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0201 | 0 | 0.5 |
Onchocerca volvulus | 0.0201 | 0 | 0.5 | |
Brugia malayi | aryl-acylamidase | 0.0201 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1854 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0201 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0201 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0201 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0201 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0201 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0201 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency ratio (functional) | = 0.34 | Potency ratio relative to TMQ for adrenergic activtity on guinea pig right atrial (Beta-1 adrenergic receptor) tissue | ChEMBL. | 9016331 |
Potency ratio (functional) | = 0.47 | Potency ratio relative to TMQ for adrenergic activtity on guinea pig tracheal (Beta-2 adrenergic receptor) tissue | ChEMBL. | 9016331 |
Potency ratio (functional) | = 1.12 | Potency ratio of human platelet aggregation | ChEMBL. | 9016331 |
Potency ratio (functional) | = 0.34 | Potency ratio relative to TMQ for adrenergic activtity on guinea pig right atrial (Beta-1 adrenergic receptor) tissue | ChEMBL. | 9016331 |
Potency ratio (functional) | = 0.47 | Potency ratio relative to TMQ for adrenergic activtity on guinea pig tracheal (Beta-2 adrenergic receptor) tissue | ChEMBL. | 9016331 |
Potency ratio (functional) | = 1.12 | Potency ratio of human platelet aggregation | ChEMBL. | 9016331 |
Selectivity ratio (functional) | = 2.4 | Selectivity ratio of compound measured as Potency ratio of Platelet aggretation to that of potency ratio of beta2 receptor | ChEMBL. | 9016331 |
Selectivity ratio (functional) | = 3.31 | Selectivity ratio of compound measured as Potency ratio of Platelet aggretation to that of potency ratio of beta1 receptor | ChEMBL. | 9016331 |
Selectivity ratio (binding) | = 1.38 | Selectivity ratio of compound measured as Potency ratio of beta2 receptor to that of potency ratio of beta1 receptor | ChEMBL. | 9016331 |
Selectivity ratio (functional) | = 2.4 | Selectivity ratio of compound measured as Potency ratio of Platelet aggretation to that of potency ratio of beta2 receptor | ChEMBL. | 9016331 |
Selectivity ratio (functional) | = 3.31 | Selectivity ratio of compound measured as Potency ratio of Platelet aggretation to that of potency ratio of beta1 receptor | ChEMBL. | 9016331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.