Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.0152 | 0.0152 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0202 | 0.0152 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.004 | 0.2642 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.004 | 0.004 |
Entamoeba histolytica | cyclin, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0202 | 0.0152 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0202 | 0.0152 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.1937 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0202 | 0.0152 | 0.0152 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0202 | 0.0152 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.004 | 0.004 |
Mycobacterium leprae | Possible lipase LipU | 0.0202 | 0.0152 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0202 | 0.0152 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0202 | 0.0152 | 1 |
Mycobacterium ulcerans | esterase LipW | 0.0202 | 0.0152 | 0.5 |
Plasmodium falciparum | cyclin | 0.0021 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0202 | 0.0152 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0202 | 0.0152 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0202 | 0.0152 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Onchocerca volvulus | 0.0202 | 0.0152 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0069 | 0.004 | 0.004 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0202 | 0.0152 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Giardia lamblia | Cyclin A | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.004 | 0.004 |
Brugia malayi | aryl-acylamidase | 0.0202 | 0.0152 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0202 | 0.0152 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0021 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.004 | 0.2642 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0202 | 0.0152 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0069 | 0.004 | 0.004 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | ammd protein | 0.0202 | 0.0152 | 0.0152 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0202 | 0.0152 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0069 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 1.1937 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0202 | 0.0152 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0202 | 0.0152 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.004 | 0.004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | In vitro inhibition of recombinant Cyclin Dependent Kinase-2/Cyclin E. | ChEMBL. | 15012993 |
IC50 (binding) | = 4 nM | In vitro inhibition of recombinant Cyclin Dependent Kinase-2/Cyclin E. | ChEMBL. | 15012993 |
IC50 (functional) | = 80 nM | In vitro inhibition of SW480 (human colon cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 80 nM | In vitro inhibition of SW480 (human colon cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 300 nM | In vitro inhibition of MDA MB 435 (human breast cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 300 nM | In vitro inhibition of MDA MB 435 (human breast cancer) cell proliferation. | ChEMBL. | 15012993 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15012993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.