Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible lipase LipU | 0.0222 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.3114 | 1 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0222 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0222 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0222 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0222 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0222 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0222 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0222 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3114 | 1 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0222 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0222 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0222 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0222 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0222 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0222 | 0 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0222 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3114 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0222 | 0 | 0.5 |
Onchocerca volvulus | 0.0222 | 0 | 0.5 | |
Mycobacterium ulcerans | lipase LipU | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0222 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0222 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0222 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0222 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.3114 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3114 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0222 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Biodistribution (ADMET) | = 0.11 % | Evaluated for biodistribution in rat thyroid after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.14 % | Evaluated for biodistribution in rat thyroid after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.19 % | Evaluated for biodistribution in rat heart after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.28 % | Evaluated for biodistribution in rat thyroid after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.42 % | Evaluated for biodistribution in rat blood after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.44 % | Evaluated for biodistribution in rat heart after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 0.83 % | Evaluated for biodistribution in rat blood after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 1.51 % | Evaluated for biodistribution in rat brain after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 1.96 % | Evaluated for biodistribution in rat lung after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 2.36 % | Evaluated for biodistribution in rat brain after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 2.4 % | Evaluated for biodistribution in rat brain after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 2.76 % | Evaluated for biodistribution in rat heart after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 2.98 % | Evaluated for biodistribution in rat kidney after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 3.52 % | Evaluated for biodistribution in rat blood after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 4.36 % | Evaluated for biodistribution in rat lung after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 6.19 % | Evaluated for biodistribution in rat kidney after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 7.69 % | Evaluated for biodistribution in rat kidney after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 7.81 % | Evaluated for biodistribution in rat liver after 6 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 9.52 % | Evaluated for biodistribution in rat liver after 2 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 18.31 % | Evaluated for biodistribution in rat liver after 1 min of administration | ChEMBL. | 7108905 |
Biodistribution (ADMET) | = 22.63 % | Evaluated for biodistribution in rat lung after 2 min of administration | ChEMBL. | 7108905 |
Brain uptake (ADMET) | = 2.09 % | Evaluated for the carrier level on brain uptake at 4 mg/kg dose in rat | ChEMBL. | 7108905 |
Brain uptake (ADMET) | = 2.43 % | Evaluated for the carrier level on brain uptake at 40 mg/kg dose in rat | ChEMBL. | 7108905 |
Brain uptake (ADMET) | = 2.67 % | Evaluated for the carrier level on brain uptake at 0.04 mg/kg dose in rat | ChEMBL. | 7108905 |
Brain uptake (ADMET) | = 3.03 % | Evaluated for the carrier level on brain uptake at 0.4 mg/kg dose in rat | ChEMBL. | 7108905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.