Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ecotin, putative | 0.0232 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0232 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0556 | 0.0241 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3689 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0232 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.3689 | 1 | 0.5 |
Onchocerca volvulus | 0.0232 | 0 | 0.5 | |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0232 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3689 | 1 | 1 |
Brugia malayi | aryl-acylamidase | 0.0232 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0556 | 0.0241 | 1 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0232 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0232 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0232 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.3689 | 1 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0232 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0232 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0232 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.3689 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0232 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0232 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0232 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0232 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7 % | In vivo antinociceptive activity was determined by mouse abdominal irritant test (MAIT) in male pathogen free albino CD-1 mice | ChEMBL. | 11300868 |
Ki (binding) | = 3.7 nM | In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat | ChEMBL. | 11300868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.