Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible esterase LipW | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0188 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0188 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0188 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1091 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0188 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0188 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0188 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0188 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0188 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0188 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.1091 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0188 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0188 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0188 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0188 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1091 | 1 | 1 |
Mycobacterium ulcerans | esterase LipW | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0188 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.1091 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0188 | 0 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0188 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1091 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0188 | 0 | 0.5 |
Onchocerca volvulus | 0.0188 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0188 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0188 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0188 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0188 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0188 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0188 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3700 uM | Tested for binding affinity of the compound towards Protein-tyrosine Phospatase 1B | ChEMBL. | 10853661 |
IC50 (binding) | = 3700 uM | Tested for binding affinity of the compound towards Protein-tyrosine Phospatase 1B | ChEMBL. | 10853661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.