Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | 0.0283 | 0.0469 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.009 | 0.0103 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.009 | 0.0103 | 0.0103 |
Leishmania major | ecotin, putative | 0.009 | 0.0103 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.036 | 0.0613 | 0.0506 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.009 | 0.0103 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5323 | 1 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.009 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.009 | 0.0103 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.5323 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.009 | 0.0103 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tumor protein p63 | 0.036 | 0.0613 | 0.0506 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0027 | 0.0027 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.009 | 0.0103 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.009 | 0.0103 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0283 | 0.0469 | 1 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.009 | 0.0103 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.009 | 0.0103 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.009 | 0.0103 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.0396 | 0.0287 |
Brugia malayi | glutaminase DH11.1 | 0.0283 | 0.0469 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0027 | 0.0584 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0113 | 0.2403 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.009 | 0.0103 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.009 | 0.0103 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.009 | 0.0103 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.009 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.009 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.009 | 0.0103 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.0396 | 0.0287 |
Loa Loa (eye worm) | ammd protein | 0.009 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0396 | 0.0396 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0031 | 0.0031 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0031 | 0.0663 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.009 | 0.0103 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0113 | 0.0113 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | aryl-acylamidase | 0.009 | 0.0103 | 0.0103 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.009 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.009 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.009 | 0.0103 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.009 | 0.0103 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.009 | 0.0103 | 0.2206 |
Brugia malayi | hypothetical protein | 0.0245 | 0.0396 | 0.8457 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5323 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 0.0032 | 0.0661 | |
Loa Loa (eye worm) | hypothetical protein | 0.5323 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | glutaminase | 0.0283 | 0.0469 | 0.0469 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.009 | 0.0103 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0283 | 0.0469 | 0.0469 |
Schistosoma mansoni | glutaminase | 0.0283 | 0.0469 | 0.0469 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.009 | 0.0103 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0113 | 0.0113 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0031 | 0.0663 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 14 % | Maximum percentage reduction in mean blood pressure in metacorticoid (DOCA) hypertensive rats at a standard oral dose of 100 mg/kg | ChEMBL. | 3361579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.