Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | inositol 1,4,5-trisphosphate receptor, type 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1646 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0216 | 0.0083 |
Schistosoma mansoni | ryanodine receptor related | 0.0131 | 0.0372 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0334 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.035 | 0.0219 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0111 | 0.0241 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1646 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.0015 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0094 | 0.0134 | 0.0134 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0094 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.1646 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1646 | 1 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0163 | 0.0575 | 0.0367 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0111 | 0.0241 | 0.5 |
Brugia malayi | cation channel family protein | 0.0201 | 0.0813 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1646 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 170 nM | Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor | ChEMBL. | 11958992 |
Kd (binding) | = 170 nM | Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor | ChEMBL. | 11958992 |
Kd (binding) | = 3200 nM | Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor | ChEMBL. | 11958992 |
Kd (binding) | = 3200 nM | Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor | ChEMBL. | 11958992 |
Relative affinity (binding) | = 0.47 | Affinity of the compound towards IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor was determined relative to compound 2 | ChEMBL. | 11958992 |
Relative affinity (binding) | = 8.8 | Affinity of the compound towards IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor was determined relative to compound 2 | ChEMBL. | 11958992 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.