Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0258 | 0.0065 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.5212 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0258 | 0.0065 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0258 | 0.0065 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.5212 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0258 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | ammd protein | 0.0258 | 0.0065 | 0.0065 |
Mycobacterium ulcerans | lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0258 | 0.0065 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.0065 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0258 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0258 | 0.0065 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0258 | 0.0065 | 0.5 |
Onchocerca volvulus | 0.0258 | 0.0065 | 1 | |
Leishmania major | ecotin, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0258 | 0.0065 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0258 | 0.0065 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0258 | 0.0065 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0258 | 0.0065 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0258 | 0.0065 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0258 | 0.0065 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 4 mg kg-1 | Oral gastric cytoprotective activity in the rat against ethanol-induced lesions | ChEMBL. | 4009611 |
Inhibition (functional) | = 16 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 0.1 mg/kg given intravenously | ChEMBL. | 4009611 |
Inhibition (functional) | = 54 % | Inhibition of histamine stimulated gastric acid secretion in mongrel dogs following 4 mg/kg p.o. administration. | ChEMBL. | 4009611 |
Inhibition (functional) | = 91 % | Gastric antisecretory activity in the pylorus-ligated rat and the reduction in acid output was measured after 4 hr by intraperitoneal (ip) administration of 40 mg/kg dose. | ChEMBL. | 4009611 |
Inhibition (functional) | = 93 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 8 mg/kg given orally | ChEMBL. | 4009611 |
Inhibition (functional) | = 95 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 2 mg/kg given intravenously | ChEMBL. | 4009611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.