Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.129 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.129 | 0.5 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.129 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.129 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.129 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Percentage reduction of thrombus formation by weight in rat (intraperitoneal administration) | ChEMBL. | 8464044 |
LD50 (functional) | = 220 mg | Antithrombotic activity of the compound was determined at 100 mg/kg for nonlethal dose in rat | ChEMBL. | 8464044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.