Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2194 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2194 | 0.5 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2194 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2194 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2194 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6 mg kg-1 | Oral gastric cytoprotective activity in the rat against ethanol-induced lesions | ChEMBL. | 4009611 |
Inhibition (functional) | = 21 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 8 mg/kg given orally | ChEMBL. | 4009611 |
Inhibition (functional) | = 44 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 2 mg/kg given intravenously | ChEMBL. | 4009611 |
Inhibition (functional) | = 48 % | Gastric antisecretory activity in the pylorus-ligated rat and the reduction in acid output was measured after 4 hr by intraperitoneal (ip) administration of 40 mg/kg dose. | ChEMBL. | 4009611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.