Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0258 | 0.0065 | 0.5 |
Leishmania major | ecotin, putative | 0.0258 | 0.0065 | 0.5 |
Onchocerca volvulus | 0.0258 | 0.0065 | 1 | |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0258 | 0.0065 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0258 | 0.0065 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0258 | 0.0065 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0258 | 0.0065 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0258 | 0.0065 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0258 | 0.0065 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0258 | 0.0065 | 0.0065 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0258 | 0.0065 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0258 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.5212 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0258 | 0.0065 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.5212 | 1 | 1 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0258 | 0.0065 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0258 | 0.0065 | 0.0065 |
Mycobacterium ulcerans | lipase LipU | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0258 | 0.0065 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0258 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0258 | 0.0065 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0258 | 0.0065 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0258 | 0.0065 | 0.0065 |
Echinococcus multilocularis | hormone sensitive lipase | 1.5212 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0258 | 0.0065 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 5 mg kg-1 | Oral gastric cytoprotective activity in the rat against ethanol-induced lesions | ChEMBL. | 4009611 |
Inhibition (functional) | = 36 % | Inhibition of histamine stimulated gastric acid secretion in mongrel dogs following 4 mg/kg p.o. administration. | ChEMBL. | 4009611 |
Inhibition (functional) | = 39 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 8 mg/kg given orally | ChEMBL. | 4009611 |
Inhibition (functional) | = 72 % | Gastric antisecretory activity in the pylorus-ligated rat and the reduction in acid output was measured after 4 hr by intraperitoneal (ip) administration of 40 mg/kg dose. | ChEMBL. | 4009611 |
Inhibition (functional) | = 96 % | Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at dose 5 mg/kg given intravenously | ChEMBL. | 4009611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.